Children's Autism Metabolome Project
Autism Spectrum DisorderDevelopmental DisorderDevelopment and Clinical Evaluation of the Stemina Metabolic Biomarker-Based Test to Diagnose Autism Spectrum Disorder in Early Childhood.
Autism Registry for French Guiana
Autism Spectrum DisorderThe objective of the autism registry is to estimate the prevalence of autism in French Guiana in the cohort of children aged 8 years. Secondary objectives are to determine the prevalence of comorbidities, and to determine the theoretical and actual orientation of these children regarding care and education in a territory with significant structural deficits relative to mainland France. The outcomes of this registry will be to guide decision makers in their funding priorities to improve, screening, diagnosis, care and education for children on the autistic spectrum
Diagnostic Performance of Exome Sequencing in Autism Spectrum Disorders
Autism Spectrum DisorderEvaluation of the diagnostic performance of exome sequencing in a prospective series of patients with autism spectrum disorders (ASD).
Occurrence of Traumatic Dental Injury in a Group of Egyptian Autistic Children Compared to Normal...
Traumatic Dental InjuryAutism Spectrum Disorder1 moreThe aim of the study is to assess the occurrence of traumatic dental Injury in a group of Egyptian Autistic Children compared to normal children. Population: Egyptian children Exposure: Autistic children. Control: Normal children. Outcome: Primary Outcome: occurence of Traumatic injury. Secondary Outcome: Risk factor, Oral habits.
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Autism
AutismAutism Spectrum Disorder17 moreThis study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding autism.
Measurement of Joint Attention Fluency
Autism Spectrum DisordersAutismThe purpose of this research is to study joint attention. Joint attention plays a critical role in social and language development in children with and without autism. Joint attention is the shared attention between a child and another person. This study seeks to set a standard benchmark of frequency scores for joint attention. Finding a rate of engaging in joint attention behavior would offer a benchmark for all researchers and practitioners working with learners with and without autism.
Participant Database for Autism Research Studies
Autism Spectrum DisorderThe purpose of this study is to create a subject database to recruit for current and future studies in research on autism and other neurodevelopmental disabilities.
Visual Exploration and Attention: Studies in Patients With Schizophrenia and Autism Spectrum Disorders...
Autism Spectrum DisordersSchizophreniaThe aim of the protocol is to better understand the impairments in visual processing, as such impairments may induce social interaction difficulties in subjects with autism spectrum disorders (adults and children) and schizophrenia, like face exploration.The same protocol will be used for the three populations, each population being compared with matched controls. The explorations are designed to test two different hypotheses regarding the mechanisms of the visual perception difficulties of the two populations. Even though difficulties to extract the global form of objects have been described in both subjects with autism and schizophrenia, we will test two different hypotheses for the two populations. We will test the hypothesis that subjects with autism display an advantage for the processing of local information arising at an early level of processing, whereas disorders observed in patients with schizophrenia originate from attention disorders. The protocol includes three consecutive studies, each one being applied in each of the three populations.
Assessment of Movement Skills in Autism Spectrum Disorder
Movement Disordersthis study is to explore the degree of impairement in movement skills in children with autistic spectrum disorders
Susceptibility Genes in Autism Spectrum Disorders
Autism Spectrum DisordersThe main objective of the study is to define, for Autism Spectrum Disorder, the extent of genetic variation in synaptic pathways that may be targeted for therapeutic development. For this purpose the investigators will take advantage of large, well-characterized cohorts of patients with Autism Spectrum Disorder for genetic screenings. Targeted sequencing of selected synaptic genes, previously associated with Autism Spectrum Disorder, will be carried out in these cohorts with deep coverage of coding regions and a strong focus on previously untested regulatory regions. Genomic data from Copy Number Variant, whole genome sequencing and exome sequencing, available for some of these patients, will be integrated in the overall analysis. The investigators will strongly emphasize the establishment of comprehensive genotype/phenotype correlations and set up an induced Pluripotent Stem Cells collection from selected patients with synaptic mutations for functional and expression analysis.