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Active clinical trials for "Purpura, Thrombocytopenic, Idiopathic"

Results 251-260 of 380

Platelet Function in Idiopathic Thrombocytopenic Purpura (ITP) Patients With Eltrombopag

Idiopathic Thrombocytopenic Purpura

This is a single-center, prospective, controlled study with one eltrombopag treatment group and 2 control groups, one on standard steroid treatment, and another one untreated. The aim of the study is to determine the effect of Thrombopoietin Receptor (MPL) agonists on shear-induced platelet activation.

Completed20 enrollment criteria

Pilot Study of Rituximab for the Treatment of Acute Immune Thrombocytopenic Purpura (ITP)

PurpuraThrombocytopenic1 more

The purpose of this study is to assess the feasibility of a randomized, double blind, placebo controlled trial of add-on rituximab for non-splenectomized adults with acute immune thrombocytopenic purpura (ITP).

Completed23 enrollment criteria

A Trial to Treat Patients With ITP Who Do Not Achieve a Durable Response to Rituxan Alone

Idiopathic Thrombocytopenic Purpura (ITP)

The purpose of this research study is to compare the efficacy and safety of higher doses of rituximab to a combination of standard doses of Rituxan + CVP (Cyclophosphamide, Vincristine, and Prednisone) in patients with chronic Idiopathic Thrombocytopenic Purpura (ITP who did not respond to or relapsed after standard doses of rituximab.

Withdrawn26 enrollment criteria

A Multicentre Investigation of 2 Cycles Rituximab Compared With Standard Regimen in Management of...

Immune Thrombocytopenia

The project was undertaking by Qilu Hospital, Shandong University and other several well-known hospitals in China. In order to report the efficacy and safety of Rituximab in different frequencies for the treatment of adults with steroid-resistant/relapsed immune thrombocytopenia (ITP).

Withdrawn12 enrollment criteria

A Multicenter Investigation of Recombinant Human Thrombopoietin (rhTPO) Combining Cyclosporin A...

Immune Thrombocytopenia

The project was undertaking by Qilu Hospital of Shandong University and other 5 well-known hospitals in China. In order to report the efficacy and safety of recombinant human thrombopoietin combining with cyclosporin A for the treatment of adults with refractory immune thrombocytopenia (ITP), compared to cyclosporin A monotherapy.

Withdrawn10 enrollment criteria

Assesment of the Functional Activity of Platelets for the Differential Diagnosis of Thrombocytopathies...

Immune ThrombocytopeniaThrombocytopathy2 more

The purpose of this study is to develop a highly sensitive method for assessing the functional activity of platelets for use in the differential diagnosis of thrombocytopenia and platelet defects.

Not yet recruiting6 enrollment criteria

Real World Evaluation of the Activity and Safety of Fostamatinib in Consecutive Adult Patients With...

ITP - Immune ThrombocytopeniaChronic ITP1 more

This is a retrospective and prospective multicenter observational study with the aim to evaluate the real-life use of Fostamatinib in adult patients with chronic ITP, refractory to other treatments.

Not yet recruiting5 enrollment criteria

Single Incision Versus Standard Laparoscopic Splenectomy

Hereditary SpherocytosisIdiopathic Thrombocytopenic Purpura

This is a prospective trial of single incision versus standard 4-port laparoscopic splenectomy. The hypothesis is that there may be a difference in wound infection rates, operative time, doses of analgesics post-operatively, and patient/parent perception of scars. However, the technical difficulty is considerable and the primary outcome is operative time which will be expressed in minutes.

Withdrawn2 enrollment criteria

Dietary Phytoestrogens as Risk Factors for Systemic Lupus Erythematosus

Lupus ErythematosusRheumatoid Arthritis1 more

The study aims at determining if dietary phytoestrogens can be risk factors for Systemic Lupus Erythematosus (SLE). Dietary enquiry and phytoestrogens measurements will be performed in blood and urine of patients with SLE in an active phase of the disease, in patient with other autoimmune diseases and in healthy volunteers. Subjects will be premenopausal women and when possible at a define stage of the menstrual cycle. Free blood estradiol will be assayed as a confounding risk factor.

Completed22 enrollment criteria

Relative Bioavailibilty for Pediatric Powder for Suspension (PfOS) Formulation and Food Effect

PurpuraThrombocytopaenic1 more

This is a randomized, open-label, five-period, balanced crossover study conducted in approximately 40 healthy adult subjects enrolled at one study center in the USA. Subjects receive five eltrombopag treatments: tablet fasted, Powder for Oral Suspension (PfOS) fasted, PfOS with a high calcium meal, PfOS 2 hours prior to a high calcium meal, and PfOS 2 hours after a high calcium meal, and each treatment is a single 25 mg dose. There is a 10 to 14 day washout between periods, and between the last dose of study drug and the follow-up visit. During each treatment period, subjects undergo serial PK sampling over 72 hours for measurement of plasma eltrombopag concentrations. Safety is assessed by vital signs, clinical safety laboratory assessments, and adverse events reporting.

Completed28 enrollment criteria
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