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Active clinical trials for "Bacteremia"

Results 231-240 of 283

Spanish Bacteriemia Cohort 2016: Epidemiology, Clinical Management and Prognosis Factors

Bacteremia

Bacteremia The Hypothesis of the study are the followings: To demonstrate relevant epidemiologic and clinical changes with potentially impact in the management and prognosis of the patients with bacteremia. Since the diagnosis and management is heterogeneous between centers, we could identify a scenario to improve. To identify quality indicators in the management of bacteremia. To demonstrate that some interventions made by Bacteremia Team pose relevant impact in the prognosis of bacteremia.

Completed4 enrollment criteria

Blood Culture Improvement Guidelines and Diagnostic Stewardship for Antibiotic Reduction in Critically...

SepsisBacteremia

This study will test the hypothesis that reliable implementation of an evidence-based clinical practice guideline for evaluation of patients with signs and symptoms of sepsis will decrease antibiotic use in pediatric intensive care units (PICUs).

Completed2 enrollment criteria

Evaluation of Bacteremia Epidemiology During the COVID Period in One French University Hospital...

BacteremiaCatheter-Related Infections

The main objective of this retrospective cohort is to evaluate the impact of the first epidemic wave during lockdown on bacteremia epidemiology in one French University Hospital.

Completed2 enrollment criteria

Ultra Rapid Culture Independent Detection of High-Priority Carbapenem Resistant Enterobacteriaceae...

BacteremiaEnterobacteriaceae Infections

The purpose of this study is to develop a new and very rapid diagnostic test for identifying a certain type of bacteria called Enterobacteriaceae in blood. Rapid identification of bacteria will assist in decreasing the use of antibiotics and help more patients survive bacterial infections of the blood.

Completed3 enrollment criteria

Central Venous Catheter Lock Solution

Bacteremia

The purpose of this study is to determine whether the application of 47% citrate lock solution decreases the incidence of infection and thrombosis of central venous catheter in hemodialysis population.

Unknown status2 enrollment criteria

Study of Cases of Serious Infections Due to Carbapenem-Resistant Enterobacteriaceae

Urinary Tract InfectionComplicated4 more

A multi-center, retrospective study of cases of serious bacterial infections including complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP), Hospital Acquired Bacterial Pneumonia (HABP), Ventilator Acquired Bacterial Pneumonia (VABP), and/or bacteremia caused by Carbapenem-Resistant Enterobacteriaceae (CRE)

Completed4 enrollment criteria

Detecting Infections Rapidly and Easily for Bacteremia Trial (DIREBT)

Bacteremia

To assure the uniform collection, handling, storage and transport of patient whole blood specimens and associated information to support validation of the T2 Bacteremia Assay.

Completed17 enrollment criteria

Blood Cultures's Profitability in Intensive Care Unit

Bacteremia

The purpose of this study is to assess the blood cultures' profitability in intensive care unit and create a validated prediction rule for extractioning in critical patients.

Completed2 enrollment criteria

Fast Assay for Pathogen Identification and Characterization

BacteremiaSepsis1 more

Sepsis is a life-threatening disease caused by a dysregulated host response to infection. This can lead to organ-dysfunction and septic shock, which is a subset of sepsis where underlying abnormalities increase mortality remarkably. Blood cultures are the gold standard for identifying pathogens in the bloodstream (bacteremia). It is based on cultivation techniques which, theoretically, can detect a single pathogenic cell from a patient sample. However, blood cultures have serious limitations, such as long time to result (3-7 days). This leads to the fact that only a small fraction of the patients obtain a correct diagnosis and in further consequence get the optimal antimicrobial treatment. Patients with sepsis should get antimicrobial treatment within the hour. Thus, physicians start treatment empirically, with broad-spectrum antibiotics. This puts a selective pressure on pathogens and has led to an increased amount of antibiotic resistance. Faster diagnostics are necessary to ensure an immediate and targeted treatment. In the EU-funded FAPIC project, two diagnostic systems that can be used with direct sample material from patients will be developed, avoiding the time-consuming cultivation of pathogens. In this study, the evaluation of the rapid diagnostics will be performed in patients with sepsis, suspected of bacteremia. To this aim, the performance of the diagnostic systems will be evaluated using blood samples that are collected in parallel with blood cultures. In addition, clinical data of the patients will be collected. In routine care, two blood culture sets (2x2 bottles) per patient are collected. One extra blood samples (EDTA, 9 ml) will be sampled with each blood culture set, totaling 2 samples per patient. In this study, patients presenting at the Emergency Department (ED), and the department of infectious diseases/nephrology will be included. The results will be used to estimate the performance, sensitivity, and specificity of the diagnostic systems compared to blood culture. Furthermore, in order to determine the severity of sepsis and to describe the patient population, clinically relevant parameters and laboratory parameters (ferritin, HLA-DR, serum lactate, SOFA score) will be assessed to determine its association with severity of disease and patient mortality. Evaluation will be done exclusively in the lab, and will not be used directly for the diagnosis or management of patients. Standard care will still be provided.

Completed6 enrollment criteria

Procalcitonin Level as a Surrogate for Catheter-related Blood Stream Bacteremia Among Hemodialysis...

Hemodialysis Catheter Infection

Hemodialysis patients frequently develop catheter-related blood stream bacteremia (CRBSI). Procalcitonin is a marker of sepsis in bacterial infection. this study for detection of its role as a surrogacy marker in CRBSI.

Completed4 enrollment criteria
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