Active clinical trials for "Behavioral Symptoms"

To evaluate if emotion regulation group therapy skills training for adolescents and parents is an efficacious treatment when delivered as adjunctive to treatment as usual compared to a control group consisting of treatment as usual.

This pilot study investigates a new, easily applicable, individually tailored first-line behavioral training for parents of children (4-12 years) with (symptoms of) ADHD, that will be provided in an early stage, before other treatments have been applied. In this pilot study the feasibility of the newly developed intervention will be evaluated by exploring program acceptability, including client satisfaction, recruitment, retention, treatment fidelity and therapist satisfaction. Also acceptability of potential outcome measures will be explored, including preliminary tests of efficacy.

This is a placebo-controlled clinical trial to assess whether Guanfacine Extended Release (GXR) reduces aggression and self injurious behavior in individuals with Prader Willi Syndrome (PWS). In addition, the study will establish the safety of GXR with a specific focus on metabolic effects.

This is an open label, eight week, clinical trial of a proprietary high CBD/low THC sublingual solution for the treatment of clinically significant anxiety and agitation in mild to moderate Alzheimer's Disease.

RATIONALE Problems of children with disruptive (i.e., oppositional, impulsive, hyperactive, and aggressive) behaviors often grow into chronic disorders and subsequent adverse outcomes, such as school drop-out, delinquency, substance use, anti-social personality disorder, and depression. Ideally, treatment should prevent the escalation of problems, reduce the need for long and intensive or potentially harmful treatments (such as antipsychotics), and lower societal costs. Parent training has a strong effect on disruptive behaviors, however, only few families receive empirically-supported parent training. Programs are typically long and waiting lists are therefore common. Also, most existing interventions are not tailored to individual parental needs. There is thus an urgent need for brief, accessible, and individually-tailored programs. OBJECTIVES This project aims to increase the effective use of parent training for children with disruptive behaviors by (1) examining short and long-term effectiveness of a new, brief, individual, and individually-tailored parent training program with optional booster sessions to prevent relapse, compared to care as usual (CAU) in a randomized controlled trial; (2) assessing the cost-effectiveness of the brief parent training program compared to CAU. STUDY DESIGN A randomized controlled trial (RCT) with two arms will be used. Referred children and their parents will be randomly assigned (equal randomization) to (a) three sessions of brief parent training, with optional single booster sessions up to one year after the training, or (b) CAU, as regularly provided by the mental health centers involved. The study outcomes will be measured at baseline before the brief training (T0), one week after the brief training (T1), six months after T1 (T2), and twelve months after T1 (T3). For parents in the control condition, similar measurement time points will be used: before any intervention (T0), eight weeks after T0 (T1), six months after T1 (T2), and twelve months after T1 (T3). STUDY POPULATION Children with disruptive behaviors that have been referred at one of six Dutch mental health centers. INTERVENTION Parents in the intervention arm will receive a short, individualized, three-session training primarily aimed at reducing children's disruptive behaviors. It exists of two (bi)weekly individually tailored training sessions of two hours and a third session of one hour in which the training will be evaluated, and maintenance training will be provided. After that, parents wishing to receive additional support can receive single booster sessions maximum once every four weeks and/or receive care as usual. Parents in the control arm will receive care as usual for children's disruptive behavior. The treatments in both arms will be fully embedded in Dutch routine mental health care. MAIN STUDY PARAMETERS The primary outcome will be the severity of four individual target disruptive behaviors that parents want to address in the training. Secondary outcomes will be parent-reported disruptive behaviors, parent-reported child well-being, parent-reported parenting behaviors, masked audio records of mealtime routines to measure parent and child behavior, parent-reported parenting stress, parent-reported parenting self-efficacy, parent-reported parental attitude towards their child, consumption and cost of mental health care, and health state utility values. We will furthermore measure evaluations of the program by parents and therapists and explore whether parental attachment, parental psychopathology, parental reward responsivity, parent-reported child reward responsivity and punishment sensitivity moderate the intervention effects.

Novel oral anticoagulant drugs (NOACs) are now increasingly used in clinical practice. Although there are outstanding advantages of NOACs, there are also some shortcomings in use. The behavioral pattern of patients using novel oral anticoagulant drugs can directly affect the effect of anticoagulant therapy. However, at present, there is no study on behavioral patterns of compliance and cognition in patients using NOACs in China. There are few reports on the management outcomes of NOACs anticoagulant therapy as well. Above all, exploring whether pharmacists change behavioral patterns in patients using NOACs is of great significance to improve the effectiveness and safety and to prove the value of pharmacists who provide pharmaceutical care.

The goal of this pilot study is to improve the STAR-Caregivers Virtual Training & Follow-up (STAR-VTF) intervention for Latino caregivers of people living with dementia. The main objectives are to: (1) culturally adapt STAR-VTF online training modules, (2) pilot test Latino caregivers' responses to the adapted online training modules, and (3) develop an online survey to collect caregiver outcomes in a future study. Participants will receive the STAR-VTF intervention and asked to complete online surveys and participate in an exit interview to provide feedback on their experience.

The aim of this study is to investigate whether the activity in brain areas controlling the bladder is different among children suffering from Overactive Bladder (OAB) and Daytime Urinary Incontinence (DUI) compared to age- and gender-matched healthy children without bladder symptoms. Moreover, the aim is to investigate if sacral transcutaneous electric nerve stimulation (TENS) has a central mechanism of action. Children with OAB and DUI will be recruited from involved pediatric departments, and functional magnetic resonance imaging (fMRI) will be performed before and after 10 weeks of sacral TENS. In healthy children without bladder symptoms, only the baseline fMRI will be performed.

A comparative effectiveness study using an individual-level randomized design along with a pragmatic, mixed-methods approach to compare two strategies (e.g. in-person supported care, technology-supported care) all of which include evidence-based components for delivering IBD and BH care. Quantitative (e.g. self-report, electronic health record, process) and qualitative (e.g., interviews) data will be collected across multiple time points during the study period.

This study is a randomized effectiveness trial that tests the online delivery of a video-based intervention (One Talk at a Time (OTAAT)) relative to a control group over a one-year span. Hypotheses include: 1.) The OTAAT intervention will increase parental motivation to engage in racial-ethnic socialization (RES) conversations, their skills and confidence in having these conversations, and the frequency and quality of these conservations; 2.) The OTAAT intervention will increase youth reports of their coping with discrimination, perceived efficacy in coping with discrimination in the future, ethnic-racial identity, and youth mental and academic outcomes; 3.) Greater parental discrimination and youth discrimination will moderate links between OTAAT intervention and parental ethnic-racial motivation + competency as well as youth ethnic-racial identity, coping, and psychosocial outcomes.