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Active clinical trials for "Hyperbilirubinemia"

Results 11-20 of 111

Relationship Between Delayed Cord Clamping at Birth and Neonatal Bilirubin Levels in Parturients...

HyperbilirubinemiaNeonatal2 more

The purpose of the study is to determine if neonates (who already have an increased risk of hyperbilirubinemia due to mother's history of having previous neonate who received phototherapy for hyperbilirubinemia) have higher bilirubin levels 24 hours after birth with delayed cord clamping.

Suspended4 enrollment criteria

Light-emitting Diodes (LED) Phototherapy for Hyperbilirubinemia of Term Newborn

Hyperbilirubinemia

Phototherapy is almost (beside exchange transfusion) the unique treatment for hyperbilirubinemia of the newborn. Its efficacy to decrease bilirubin level (because the light interacts with bilirubin at the skin level to transform it in water soluble products eliminated in urine and stools without liver metabolism) relies on the irradiance dispensed at the skin level by the device (in the 430-490nm range) and on the exposed surface of the baby. In the past years, technology of phototherapy devices moved from fluorescent lamps to LED, improving the amount of light energy emitted but on a smaller surface. The purpose of the study is to compare the efficacy of three ramps of phototherapy, one equipped with fluorescent tubes and two with LED (in a different technological settings) in the treatment of term (35 GW or more) healthy newborn suffering hyperbilirubinemia after 2days of life.

Terminated12 enrollment criteria

A Safety and Efficacy Trial of Stannsoporfin in Neonates With Hyperbilirubinemia

HyperbilirubinemiaNeonatal

It is a normal process in the human body for red blood cells to die, which makes bilirubin. Bilirubin is cleared away through the liver. Some babies are born with livers that don't work well enough yet, or their red blood cells are dying too fast, so the baby looks yellow (jaundice). This means there is too much bilirubin in the body. It can be dangerous if a baby's bilirubin gets too high. Phototherapy is what they call the lights they shine on newborn babies to help the liver get rid of bilirubin. This study tests an experimental drug to see if it can reduce how much bilirubin is being made in the first place.

Terminated11 enrollment criteria

Transcutaneous Bilirubinometry and Phototherapy

Neonatal Hyperbilirubinemia

A randomized Controlled trial comparing the use of transcutaneous bilirubinometry to serum bilirubin measurements (via blooddraws = standard care) in neonates born after a gestational age > 32 weeks and < 15 days of age treated with Phototherapy for neonatal hyperbilrubinemia. Main outcome measurement is the number of blooddraws for measurement of bilirubin. Secondary outcome measurements are duration of phototherapy and hospitalisation.

Not yet recruiting3 enrollment criteria

the Difference of Follow-up Methods of Neonatal Jaundice

Neonatal Jaundice

The goal of this observational study is to compare the effectiveness and efficiency for precaution of severe hyperbilirubinemia in neonate by different follow-up methods of neonatal jaundice. There are two kinds of follow-up methods in our clinical practice. The one is internet plus follow-up model, the other is conventional clinic follow-up method. Parents of the participant neonates can choose one by themselves. After they signed informed consent, we recorded several information including severe hyperbilirubinemia, length of phototherapy, follow-up times, et al. Then we analysed these data in order to know what kind of follow-up method is better to prevent severe hyperbilirubinemia and more easy to accept.

Not yet recruiting9 enrollment criteria

Orlistat Treatment of Crigler-Najjar Disease

Crigler-Najjar Syndrome

The purpose of this study was to determine whether orlistat is effective in decreasing plasma unconjugated bilirubin levels in patients with Crigler-Najjar disease.

Completed2 enrollment criteria

Conjugated Hyperbilirubinemia and Pulse Oximetry

Liver DiseaseHyperbilirubinemia

The purpose of this study is to determine if higher levels of bilirubin in the blood of people with liver disease affects how accurate a pulse oximeter machine is able to measure the concentration of oxygen in the blood. Previous studies have reported conflicting results regarding the affect of high levels of bilirubin in the blood on the accuracy of the pulse oximeter reading. Initial studies showed an underestimation of the oxygen concentration in the presence of elevated bilirubin. Subsequent studies have suggested that high levels of bilirubin in the blood do not influence the accuracy of the pulse oximeter machine. However, recent reports in bone marrow transplant literature and our personal observations in patients with liver disease suggest that high bilirubin levels are associated with an overestimation of the oxygen concentration as measured by the pulse oximeter machine.

Terminated3 enrollment criteria

Safety and Pharmacology of Stanate

Hyperbilirubinemia

The purpose of this study is to evaluate the effect and safety of Stanate (stannsoporfin) in infants who are at risk for an exchange transfusion and meet the criteria of the protocol.

Completed5 enrollment criteria

Trial of Aggressive Versus Conservative Phototherapy in Infants <1,000 Grams Birth Weight

HyperbilirubinemiaNeonatal10 more

This multi-center, randomized clinical trial compared different bilirubin levels as thresholds for timing of phototherapy in extremely low birth weight infants. The primary hypothesis was that there would be no difference in death or neurodevelopmental impairment at 18-22 months corrected age in infants treated by either aggressive or conservative threshold limits. 1,978 infants were enrolled.

Completed10 enrollment criteria

Home Phototherapy for Term Newborns With Icterus

Neonatal Hyperbilirubinemia

The study is designed as a randomised controlled multicenter study.The primary aim is to investigate if home phototherapy improves parent-child bonding compared to if treatment is performed at the hospital. The investigators will also istudy how home phototherapy is perceived by the parents, impact on breastfeeding and parents stress levels, if the method can be implemented etc. Patients are included at 5 hospitals in Sweden. The plan is to include 250 term newborns with neonatal icterus at a level that needs phototherapy treatment.

Completed4 enrollment criteria
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