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Active clinical trials for "Blindness"

Results 121-130 of 134

The Connection Between Areas in the Brain of Blind Patients

BlindnessBrain Mapping1 more

The purpose of this study is to test the belief that specific areas of the brain are connected differently in blind patients than patients with sight. In addition, the study will examine the different anatomical connections between brain areas of patients who became blind early in life versus patients who became blind later.

Completed12 enrollment criteria

Prevalence of Blindness, Visual Impairment in Chao Nan Area, China

BlindnessCataract2 more

This study will provide a profile of blindness/visual impairment, avoidable blindness and cataract surgery service in Chaonan, mainland China. We also evaluate the diagnostic accuracy of Rapid Assessment of Avoidable Blindness (RAAB) comparison with conventional survey.

Completed6 enrollment criteria

Natural History Study of CEP290-Related Retinal Degeneration

BlindnessLeber Congenital Amaurosis 107 more

A prospective natural history study with systematic assessments and uniform follow-up to provide a high-quality dataset for assisting in the design of future clinical treatment trials involving patients with CEP290-related retinal degeneration caused by the common intron 26 mutation.

Completed11 enrollment criteria

Genetic Decryption of Leber Congenital Amaurosis (LCA) in a Large Cohort of Independent Families....

Leber Congenital Amaurosis

The main objectives of this study are: Improve genetic counseling by establishment of prevalences of each of genetic subtypes within a expanded population of patients with LCA taking into account ethnicity of families. Confirm, refine or modify the genotype-phenotype correlations. Edit important recommendations for: The clinical and paraclinical exploration of a new patient based on genotype, especially for extraocular explorations, to book at certain genetic subtypes Prenatal care of a couple. Directing families to a therapeutic protocol in progress or in development. Individualize a panel of families without a mutation in the known genes and identify new genes responsible.

Completed10 enrollment criteria

Perception of Objects and Natural Scenes in People With Vision Loss (ACTIVIS)

Vision Loss

The loss of central vision causes difficulty not only in reading but also in faces recognition, and in particular in the identification of facial expression, objects or spaces. These visual deficits have been mainly studied in relation with reading, which is the main complaint of these kind of patients. However, there are not enough data regarding perception of objects and spaces in this population. Then, the objectives are to study the visual-spatial abilities in individuals with vision loss, and altered cognitive processes, (2) to develop clinics tools for early detection and quantification of visual-spatial deficits and (3)to understand the capacities of normal peripheral vision in order to test the possibility of potential training for use of peripheral vision when central vision is impaired by an ophthalmic pathology.

Completed14 enrollment criteria

Effects of Sevoflurane and Propofol on Light Flashed Evoked Pupillometry

Blindness

This is a study to focus on the feasibility of using a monitor which may signal loss of visual function intraoperatively.

Completed3 enrollment criteria

Natural History Study in Inherited Retinal Disease Subjects Caused by Mutations in RPE65 or LRAT...

Leber Congenital Amaurosis (LCA)Retinitis Pigmentosa (RP)

To evaluate the natural history of visual function in subjects with IRD phenotypically diagnosed as Leber congenital amaurosis (LCA) or retinitis pigmentosa (RP) caused by RPE65 or LRAT gene mutations.

Completed5 enrollment criteria

Low-vision Rehabilitation Program for Low-vision Patients and Care Givers

Low VisionOne Eye3 more

To evaluate health related quality of life (HRQoL) of low-vision patients and their care givers undergoing low-vision rehabilitation program (LVRP).

Unknown status9 enrollment criteria

Intentional Blindness During Perioperative Cardiac Arrest

Cardiac Arrest

Cardiac arrest in the operating room is a rare but potentially catastrophic event with mortality rates greater than 50%. Recent CPR guidelines published by the American Heart Association (AHA) and the Heart and Stroke Foundation of Canada (HSFC) describe how high quality CPR improves survival rates and neurological outcomes from cardiac arrest. Despite CPR training, adherence rates with performance guidelines are alarmingly low in many pediatric hospitals . In addition to performance errors, medication errors have been reported to be as high as 50% during cardiopulmonary arrest. This can be attributed to many factors, including distractions and poor communication among team members. Previous studies suggested that loud noise in the operating room caused poor communication and impaired surgical performance. To understand more about simulation awareness during peri-operative cardiac arrest, the investigators are planning on conducting a prospective observational study, using a simulated perioperative cardiac arrest scenario in pediatric hospital.The investigators are aiming for a convenient sample of 20 simulation sessions. Each session will have a team of CPR providers (2 participants and 4 confederates). The 2 participants will include one anesthesiologist and one operating room nurse. The participants will be randomized into two group; group A will work in a noise environment of 85 dBA ( as per recommendation by the National Institute for Occupational Safety and Health (NIOSH), and group B will work in a noise environment of 100 dBA. Participants will be wearing eye tracking devices during the scenario (Tobii Pro GlassesTM) designed to capture areas of interest (AOI) / visual fixation. The investigators hypothesize that CC and medication errors are frequently left undetected and uncorrected, and that the less noise distractions during resuscitation improves but does not eliminate this pattern of inattentional blindness in resuscitation teams during simulated perioperative pediatric cardiac arrest. They also hypothesize that "look but not act" events are a frequent occurrence during simulated pediatric cardiac arrest, and that healthcare providers will have varying reasons that explain the occurrence of "look but not act" events.

Unknown status4 enrollment criteria

Determinants of Cognitive Impairment Among Geriatrics

Cognitive ImpairmentDementia10 more

This study aims to explore the determinants of cognitive impairment among Indonesian geriatrics in an Old Age Home.

Unknown status4 enrollment criteria
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