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Active clinical trials for "Blood Coagulation Disorders"

Results 441-450 of 450

Noninvasive Measurement of Blood Coagulation

Anticoagulants; IncreasedAnticoagulant Overdosage3 more

The investigators have developed an optical system that measures the coagulation status of patients in vivo in a non-invasive manner. The system is based on a small optical sensor that emits coherent light into the skin and collects the reflected light from the red blood cells in the blood vessels in the skin under the sensor. The sensor is placed on the fingertip, and during a brief period of occlusion of blood flow by a small pneumatic cuff, red cell movement becomes Brownian in nature and is thereby affected by the viscosity of the blood. In patients who have a bleeding tendency, red blood cell movement will be faster, while in patients with a hypercoagulable state the red cell movement will be slower. Treatment with anticoagulant medications is expected to affect the movement of the red blood cells and these changes can be detected by the sensor. The investigators plan to test the device in normal subjects and in subjects taking Coumadin, direct oral anticoagulants, antiplatelet drugs and heparin-based medications. The investigators will determine whether anticoagulants affect the noninvasive measurement and compare the results with standard laboratory tests of coagulation.

Unknown status2 enrollment criteria

Impact of Renal Replacement Therapy on Coagulation Profile of Patients With Acute Renal Failure...

Acute Renal FailureHemorrhage1 more

Renal failure and high plasmatic level of urea have been associated with an increased risk of hemorrhage in surgical patients. There is only sparse data on the impact of renal replacement therapy on homeostatic parameters. The aim of this study is to describe potential changes in homeostatic parameters before and after renal replacement therapy.

Unknown status7 enrollment criteria

Thrombin Generation in Liver Transplant Surgery

Liver TransplantationThrombin4 more

This is a prospective observational study of 100 patients undergoing liver transplantation at a single centre. Thrombin generation and kinetics will be assessed using a novel point-of-care device, and compared to conventional measures of hemostasis as well as viscoelastic tests to pinpoint specific coagulation deficits and identify potential therapeutic targets. The clinical course of patients will be followed for major bleeding and transfusion outcomes.

Unknown status3 enrollment criteria

The Early Coagulopathy for the Prognosis in Sepsis

SepsisCoagulopathy2 more

In this cohort study, the parameters (TM, TAT, PIC, tPAIC, et al.) associated with the hemostatic system will be collected in sepsis patients when admitted to the Intensive Critical Unit. Parameters will be evaluated for their prognostic function of 28 days mortality.

Unknown status16 enrollment criteria

Hypercoagulability Study Using Haemostatic Techniques in Patients With Inflammatory Bowel Disease...

Inflammatory Bowel DiseasesThrombosis1 more

Descriptive study, in which the haemostatic profile of ambulatory patients with IBD will be analyzed by means of ROTEM and other techniques, such as the thrombin generation test and the study of platelet function by flow cytometry.

Unknown status10 enrollment criteria

ROTEM® Sigma Performance Evaluation - Method Comparison With Predicate Device and Reference Intervals...

Blood Coagulation Disorders

ROTEM® sigma is a new thromboelastometric coagulation analysis system. The new system is fully automated allowing for a simple and safe operation compared to its predecessor model ROTEM® delta. Method comparison of ROTEM® sigma with predecessor model ROTEM® delta) - confirmation of equality. Confirmation of reference intervals of the ROTEM® systems.

Unknown status20 enrollment criteria

Hemostasis Alterations in Neurosurgical Patients

GliomaCoagulopathy3 more

Prospective, observational study aimed to investigate the specific hemostatic alterations in patients undergoing glial tumor resection.

Unknown status9 enrollment criteria

Atherosclerosis in Atrial Fibrillation

Atrial FibrillationMetabolic Syndrome4 more

The prevalence of metabolic syndrome in patients suffering from non valvular atrial fibrillation is derived from studies regarding recurrences of atrial fibrillation after catheter ablation. Prospective studies in european countries are lacking. Furthermore, the impact of metabolic syndrome on cardiovascular events in patients with non valvular atrial fibrillation is still unknown.

Unknown status4 enrollment criteria

Hemostatic Complications in Hematopoietic Stem Cell Transplantation

Hemostatic Disorders

Hemostatic disorders are common and potentially fatal complications in patients undergoing hematopoietic stem-cell transplantation (HSCT). Limited data exist on early diagnosis and prevention of these complications. The investigators undertook this prospective study to determine the incidence, predictor factors, specific pathogenesis, management and survival specially for patients with thrombotic and bleeding complication to better improve outcomes.

Unknown status2 enrollment criteria

Study to Test the Accuracy of a Prototype Handheld PT/INR Device

Blood Coagulation Disorders

The purpose of this study is to measure prothrombin time (PT) on an experimental device and a commercially available device on persons receiving coumadin (warfarin)treatment.

Unknown status5 enrollment criteria
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