search

Active clinical trials for "Bone Neoplasms"

Results 231-240 of 256

Evaluation of Sodium Fluoride PET in the Identification of Bone Metastases in Patients Having Undergone...

Bone Metastasis

The purpose is to evaluate if sodium fluoride PET in patients having already undergone a choline PET negative for bone extension (non-metastatic status) modifies the status of patients concerning the existence or not of bone metastases. Secondary purposes are: To evaluate if detection of bone metastasis by sodium fluoride PET, not detected by choline PET, leads to change of treatment To evaluate inter-technique concordance (choline vs sodium fluoride PET) of results (metastatic status and number of lesions) To evaluate the inter-judge concordance of interpretation of sodium fluoride PET To study the discordance of metastatic status of 2 techniques.

Unknown status18 enrollment criteria

The Palliative Radiotherapy And Inflammation Study - PRAIS

Neoplasm MetastasisBone Neoplasms

Radiation therapy (RT) is one of the primary treatments for bone cancer pain due to metastatic cancer disease. About 6 of 10 patients obtain pain relief from RT. There are no established predictors that can be used to select patients that respond to RT. This raises the need to identify potential clinical characteristics and biomarkers that may better select patients for RT. A similar argument can be stated for the development of cachexia; there are currently no predictors that can identify patients who will develop cachexia later in the cancer disease trajectory. Cancer symptoms can be related to inflammation. Both pain, cachexia and depression are associated with inflammation in experimental and preclinical studies . Still, the clinical data on the relationship between inflammation and pain or cachexia are sparse. This is especially true for longitudinal follow-up studies. This study will include 1000 adult patients in a multicenter, multinational longitudinal observation study of patients who receive radiation therapy for bone cancer pain. Demographic data, clinical variables, genetic biomarkers and inflammatory substances will be assessed before start of RT. The primary analysis in the study is to identify potential predictors for pain relief from RT. During follow up the study will also explore for predictors for development of cachexia and which inflammatory substances that are associated with changes in pain intensity, depression and development of cachexia.

Completed11 enrollment criteria

Surgical Treatment of Long Bone Metastases

Bone MetastasesSurgery

To provide treatment guidelines for patients with long bone metastatic disease based on observational study and to propose an algorithm to guide orthopedic surgeons in decision-making for these patient.

Completed2 enrollment criteria

Retrospective Case Series of COVID19+ Patients Undergoing Orthopedic Surgery

Coronavirus InfectionOrthopedic Disorder3 more

Over the last months, the Rizzoli Orthopedic Institute in Bologna, Italy, has drained orthopedic urgencies from all other hospitals in the urban and suburban area. In this context urgencies are defined as fractures and primary or metastatic bone lesions with indication to non-deferrable surgery. A subset of these patients tested positive for SARS CoV 2, either before or after the surgical procedure. Anesthesiological clinical management of covid19 cases is complicated by the consequences of the viral infection on respiratory and cardio-vascular systems, renal function and coagulation. Similarly, management of asymptomatic patients is challenging because of the lack of data on possible specific complications. This study will report a snapshot of our early experience on perioperative clinical management of patients undergoing orthopedic surgery in the presence of SARS CoV 2 infection, ascertained or not at the time of surgery.

Completed4 enrollment criteria

Role of Positron Emission Tomography/ Computed Tomography (PET/CT) and in Bone Metastases.

Bone Metastases

The aim of this study is to detect bone metastases by PET/CT examination in cancer patients.

Completed7 enrollment criteria

Prospective PRO/QoL Registry for Patients With Bone Metastases of Breast or Prostate Cancer

Breast CancerProstate Cancer1 more

Evaluation of patient reported outcomes (PRO) / QoL regarding typical ailments in real-life patients with bone metastases treated with osteoprotective agents.

Completed5 enrollment criteria

Assessment of the Accuracy of PET/MR in Detection and Monitoring Response of Bone Metastases

Bone Metastases

The great promise of PET/MR for assessment of skeletal metastatic involvement is derived from the extensive experience with stand- alone MR, but initial data on the use of PET/MR for assessment of bone pathology indicate that PET/MR introduces unique issues that should be addressed when determining its role in this clinical scenario. In this study cohort includes 150 patients 18 years or older, having metastatic skeletal involvement on baseline PET/CT prior to treatment. Baseline studies and follow up studies of the patients referred post treatment, will be reviewed. The main goal of the study is to asses the accuracy of PET/MR in detection and monitoring response of bone metastases.

Unknown status3 enrollment criteria

Cross Cultural Validation of the Italian Version of the Bt-DUX

Quality of LifeBone Neoplasm

The purpose of the presented study is to translate the English Bt-DUX (Bt-DUX-Eng) questionnaire into the Italian language and then examine the validity of the Italian version of the Bt-DUX (Bt-DUX-It).

Completed2 enrollment criteria

Multimodal Imaging Analysis of Spinal Tumors

Bone Tumor

In this study, we retrospectively analyzed the imaging data of spinal tumors to find out more imaging features of spinal tumors, in order to provide more accurate reference for the diagnosis of spinal tumors.

Completed2 enrollment criteria

18F-NaF-PET/MR vs 99mTc-MDP-SPECT/CT to Detect Bone Metastases in Prostate Cancer Patients.

Bone MetastasesProstate Cancer

The number of metastases in a patient with primary or recurrent prostate cancer has major prognostic implication. The purpose is to compare, in a pilot study, the diagnostic performance of 18F-NaF-PET/MR with respect to the results of the scintigraphy 99mTc-MDP-SPECT/CT (routine exam) for determining the presence or absence of bone lesions in prostate cancer patient, with up to five metastases (oligo-bone metastatic) based on scintigraphy 99mTc-MDP-SPECT/CT. The gold standard will be a combination of clinical follow-up, additional imaging and biopsy, as indicated by the multidisciplinary discussion at the tumor board. The findings from whole-body 99mTc-MDP-SPECT/CT, 18F-NaF-PET/MR, and the combination of the 2 modalities will be categorized by 2 teams of 2 readers as benign or probably benign, equivocal, or malignant or probably malignant and compared with the results of follow-up for JAFROC and ROC analysis.

Completed7 enrollment criteria
1...23242526

Need Help? Contact our team!


We'll reach out to this number within 24 hrs