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Active clinical trials for "Borderline Personality Disorder"

Results 121-130 of 212

Measuring the Impact of Real Time fMRI Neurofeedback in Borderline Personality Disorder

Borderline Personality Disorder

This study will test the impacts of real time fMRI neurofeedback in patients with Borderline Personality Disorder. This is a pilot study in a small number of people enrolled in clinical programs at Yale New Haven Hospital.

Completed15 enrollment criteria

Effectiveness of a Combined Group-individual Schema Therapy for Borderline Personality Disorder...

Borderline Personality DisorderRandomized Controlled Trial

Background and Objectives: Schema therapy has been shown to be of benefit in treating borderline personality disorder. However, it is still unclear what the most suitable treatment implementation format is and to what extent therapeutic gains may be generalizable to regular healthcare settings with limited resources. Methods: A pragmatic randomized controlled trial was conducted ona representative Spanish sample of outpatients with a DSM-5 main diagnosis of borderline personality disorder. Patients were allocated either to a combined (group plus individual) schema therapy format (n=40) or to a group-only schema therapy format (n=40). Borderline personality disorder severity was the primary outcome, with other clinical variables considered as secondary outcomes (e.g., early maladaptive schemas, functioning). The assessment protocol included baseline, post-treatment (after 12months of treatment), and six-month follow-up evaluations. Data was analyzed through a two-way repeated measures ANOVA. Limitations were a limited follow-up assessment and the absence of multi-center data that detracted from the long-term stability and generalizability of the findings.

Completed7 enrollment criteria

Evaluation of DBT Compared to Drug Counseling for Opiate Addicts

Opiate AddictionBorderline Personality Disorder

The purpose of this study is to compare a one year treatment program of Dialectical Behavior Therapy (DBT) + suboxone for opiate addicted individuals meeting criteria for borderline personality disorder (BPD) to a one year program of standard drug counseling (I/GDC) + suboxone.

Completed2 enrollment criteria

Narrative Exposure Therapy in Women With Borderline Personality Disorder and Posttraumatic Stress...

Borderline Personality DisorderStress Disorders1 more

Narrative Exposure Therapy (NET) is an evidence-based trauma-focussed treatment, suitable for survivors of prolonged and repeated exposure to traumatic stress and childhood adversity. Patients with Borderline Personality Disorder (BPD) often suffer from a comorbid Posttraumatic Stress Disorder (PTSD) caused by multiple traumatic events. Therapeutic aims are the reduction of PTSD-Symptoms in these patients via activation of associative neural networks related to traumatic experiences and habituation of fear and the placement of traumatic experiences in a reconstructed, detailed and consistent autobiography. This practice enables the processing of and coping with painful memories and the construction of clear contingencies of dangerous and safe conditions, generally leading to significant emotional recovery. The investigators assume that using NET the reduction of PTSD symptom severity is greater compared to treatment by Dialectical-Behavioral Therapy (DBT).

Completed14 enrollment criteria

Creativity Group for Borderline Personality Disorder

Borderline Personality Disorder

The investigators hypothesize that a creativity skills group for Borderline Personality Disorder can reduce symptoms of BPD, depression, and anxiety.

Completed3 enrollment criteria

Safety and Efficacy Study of Citalopram and Lithium for the Treatment of Depressive Mood Disorder...

Major Depressive DisorderDysthymia2 more

The investigators hypothesize that patients receiving citalopram in combination with lithium will have a greater reduction in depressive symptoms than patients receiving citalopram in combination with placebo.

Completed10 enrollment criteria

BOSCOT : A Randomised Controlled Trial of Cognitive Behavioural Therapy in Borderline Personality...

Borderline Personality Disorder

The aim of the study was to investigate if the addition of cognitive behavioural therapy to treatment as usual (CBT plus TAU) in participants with borderline personality disorder would decrease the number of participants with emergency (i.e. unplanned) psychiatric or accident and emergency room contact or episode of deliberate self-harm over twelve months treatment and twelve months follow-up, compared with treatment as usual (TAU). The study also examined whether CBT plus TAU would lead to superior improvement in quality of life, social, cognitive and mental health functioning than TAU alone.

Completed9 enrollment criteria

PET Imaging and Olanzapine Treatment in Borderline Personality Disorder

Borderline Personality Disorder

The overall design of the study is to perform both a PET and MRI scan on objectively identified borderline personality disorder patients, to treat them with olanzapine for 8 weeks, and to then re-scan the patients with PET.

Completed11 enrollment criteria

Efficacy of Dialectical Behavior Therapy in Patients With Borderline Personality Disorder

Borderline Personality Disorder

The purpose of this study is to test the hypothesis: Primary hypothesis: Participants in the dialectical behavior therapy group have greater reductions in the frequency and severity of suicidal and non-suicidal self-injurious behaviors compared to participants in the alternative treatment group. Secondary Hypotheses: Participants in dialectical behavior therapy group have improved treatment outcomes compared to participants in alternative treatment, including mental health service utilization, symptoms of borderline personality and depression symptoms, suicidal thought and hopelessness, disability, and quality of life.

Completed9 enrollment criteria

Effects of Comorbid Personality Disorder on the Treatment of Bipolar I Disorder

Bipolar I DisorderBorderline Personality Disorder

This study will examine the impact of comorbid personality disorder on the outcome of treatment among patients with bipolar I disorder.

Completed2 enrollment criteria
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