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Active clinical trials for "Bradycardia"

Results 11-20 of 245

Bi-ventricular Epicardial Activation in Left Bundle Area Pacing: a Comparison Study

BradyarrhythmiaPacemaker Syndrome1 more

Study of the ventricular activation patterns during left bundle area pacing and compare it with baseline activation during normal sinus rhythm in patients with and without baseline bundle branch conduction disorder.

Recruiting5 enrollment criteria

The Effect of Womb Recordings on Maturation of Respiratory Control in Preterm Infants

Apnea of PrematurityIntermittent Hypoxemia1 more

The aim of this proposal is to characterize the acute effect of early postnatal sound exposure on neuronal maturation of the respiratory control regions of the brain in preterm infants.

Recruiting5 enrollment criteria

Project My Heart Your Heart: Pacemaker Reuse

Device Related InfectionDevice Malfunction1 more

Lack of access to pacemakers is a major challenge to the provision of cardiovascular health care in Low and Middle Income Countries (LMIC). Post-mortem pacemaker utilization could be safe, efficacious, and ethically responsible means of delivering the needed care. Reconditioned pacemakers can provide therapy for patients with symptomatic bradycardia and no means of receiving a new device. The objective of the clinical trial is to determine if pacemaker reutilization can be shown to be a safe means of delivering pacemakers to patients in LMIC without resources. Consented patients in this multi-center trial will be randomized to undergo implantation of either a reconditioned device or a new device.

Enrolling by invitation17 enrollment criteria

Different Approaches of Spinal Anesthesia in Patients Undergoing Cesarean Section

Post-Dural Puncture HeadacheHypotension5 more

The goal of this clinical trial is to compare different approaches of spinal anesthesia in pregnant females who are having cesarean section. The main aim is • Which approach is better in terms of avoiding intraoperative and post operative complications Participants will be given anesthesia by Midline approach paramedian approach Taylors approach

Recruiting9 enrollment criteria

Preload and Autonomic Responses With Cardiac Neuromodulation Therapy (CNT) (CS-06)

BradycardiaHypertension1 more

This investigation will evaluate the effect of RV pacing lead position on cardiac function and the modulation of the autonomic nervous system with Cardiac Neuromodulation Therapy (CNT) pacing signals. The study will be performed acutely prior to a pacemaker implant.

Recruiting14 enrollment criteria

Safety and Effectiveness of the External Fastening System for Temporary Active Fixation Pacemakers...

ArrythmiaBradycardia

Temporary cardiac pacing with active-fixation leads (TPAFL) using a reusable permanent pacemaker generator has been shown to be safer than lead systems without fixation. However, TPAFL requires the off-label (non-certificated) use of Pacemaker leads and generators. It is designed a fastening system to ensure the safety and efficacy of the procedure: the KronoSafe System®. The aim of this study is to demonstrate the safety and effectiveness of the KronoSafe System® for temporary pacing in a series of patients receiving TPAFL.

Recruiting10 enrollment criteria

BIOTRONIK Conduction System Pacing With the Solia Lead

BradycardiaAtrioventricular Block2 more

The purpose of the BIO-CONDUCT study is to demonstrate the safety and effectiveness of the BIOTRONIK Solia S pacing lead when implanted in the left bundle branch (LBB) area. Safety will be assessed by evaluating serious adverse device effects that occur through 3 months post-implant. Efficacy will be assessed by evaluating implant success rate.

Active15 enrollment criteria

Suture Closure AFtEr VEIN Access for Cardiac Procedures (SAFE-VEIN) Trial

Atrial FibrillationAtrial Flutter6 more

Primary objective: To compare the safety and efficacy of closure strategies post venous access procedures. Hypothesis: We anticipate that the use of a venous closure device will decrease the time to hemostasis (TTH), time to ambulation (TTA) and time to discharge (TTD) compared to conventional methods of closure following venous access procedure.

Active19 enrollment criteria

BIO|CONCEPT.Amvia Study

BradycardiaHeart Failure

The goal of this exploratory study is to test the preliminary safety and product performance of the new Amvia/Solvia pacemaker family in subjects that require a pacemaker or cardiac resynchronization therapy pacemaker (CRT-P) implantation. The study will be conducted at sites in Australia and New Zealand. It is planned to include 50 subjects in the study. Participants will visit sites at enrollment in the study, at implantation, pre-hospital discharge, 1- 3- and 12-month follow-up visits. At the visits the device will be interrogated and standard device measurements including those related to special features will be performed to assess the functionality of the device. Programming of the pacemakers will be done according to the participant´s therapeutical needs.

Active12 enrollment criteria

Moderato System: A Double-Blind Randomized Trial Ver 1.1

Hypertension Resistant to Conventional TherapyBradycardia1 more

The purpose of this double blind randomized study is the evaluation of the safety and efficacy of the Moderato System. The Moderato implantable pulse generator is indicated for patients who have hypertension and also require a dual chamber pacemaker in order to reduce their blood pressure. The primary objectives of this study are to provide evidence of safety and clinical efficacy of the anti-hypertensive effects of the Moderato System. This will be accomplished by evaluating changes in blood pressure in an active treatment vs. a control patient population for a period of 6 months. The device will be considered to have a clinical effectiveness with regard to its anti-hypertension functions if there is a statistically significant and clinically meaningful reduction in mean 24-hour ambulatory systolic blood pressure in the treatment group compared to the control group.

Active21 enrollment criteria
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