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Active clinical trials for "Intracranial Aneurysm"

Results 161-170 of 331

Impact of Platelet Activation in Intracranial Aneurysm Rupture Risk - PLAQRAN

Intracranial AneurysmsRuptured Aneurysm

Sub arachnoid hemorrhage consecutive to intracranial aneurysm rupture is a devastating disease. Predictors of intracranial aneurysm rupture are limited and focus mainly on size and location. Platelet activation may have a deleterious role on aneurysm rupture. The assumption is that patients with ruptured intracranial aneurysm will present a higher rate of platelet activation compared to patients with non ruptured aneurysms.

Active4 enrollment criteria

Patients' Follow-up After Subarachnoid Haemorrhage Caused by Ruptured Intracranial Aneurysms

Intracranial Aneurysms

After endovascular treatment of the intracranial aneurysm, recanalization may occur, with a risk of recurrent subarachnoid haemorrhage or long-term angiographic recurrences of aneurysms. Few data exist on patients' long-term follow-up after subarachnoid haemorrhage caused by ruptured intracranial aneurysms.

Active3 enrollment criteria

Estrogen Therapy as Prevention in the Progression of Aneurysm (EPPA) Trial

Cerebral AneurysmMenopause1 more

This study aims to determine if hormone replacement therapy, given during perimenopause may prevent the progression of saccular cerebral aneurysms.

Withdrawn8 enrollment criteria

Safety and Performance of the Penumbra Liberty Stent in the Treatment of Wide-Neck, Saccular, Intracranial...

Wide Neck Intracranial Aneurysms

The purpose of this study is to assess the safety and performance of the Penumbra Liberty Stent System as adjunctive treatment to embolic coils for wide-neck, saccular, intracranial aneurysms.

Withdrawn23 enrollment criteria

Hydrogel Balloon Assisted Intracranial Aneurysm Coiling Registry

Intracranial AneurysmsAneurysm1 more

The objective of the GELATIN registry is to prospectively evaluate intracranial aneurysm occlusion and retreatment rates as well as adverse event rates in patients undergoing balloon-assisted coiling using the MicroVention Scepter Occlusion Balloon Catheter and second-generation MicroVention hydrogel coils for treatment of previously treated or untreated ruptured and unruptured intracranial aneurysms.

Withdrawn18 enrollment criteria

Safety and Efficacy Study of a Single Dose of NA-1 in Patients Undergoing Endovascular Repair of...

Subarachnoid HemorrhageRuptured Intracranial Aneurysm

This is a randomized, double-blind, placebo-controlled, single-dose study investigating the safety and efficacy of NA-1 in patients with subarachnoid hemorrhage (SAH) undergoing endovascular repair of ruptured intracranial aneurysms. Up to 300 male and female patients with SAH undergoing endovascular repair of a ruptured intracranial aneurysm will be dosed with 2.60 mg/kg of NA-1 or placebo as a 10 minute intravenous infusion after completion of the endovascular procedure on Day 1 of the study period. Subjects will undergo interim procedures at Day 2-4, Day 30-45, and end-of-study procedures on Day 90.

Withdrawn24 enrollment criteria

Influence of MMP on Brain AVM Hemorrhage

Arteriovenous MalformationsCavernous Angiomas1 more

Brain vascular malformations, including arteriovenous malformations (AVM), cavernous malformations (CVM) and aneurysms, are a source of life-threatening risk of intracranial hemorrhage. The etiology and pathogenesis are unknown. There is no medical therapy presently available. Prevention of spontaneous intracerebral hemorrhage (ICH) is the primary reason to treat brain vascular malformations. The goal of this study is to: begin pilot studies to lay the groundwork for future clinical trials to develop medical therapy to decrease ICH risk. Matrix metalloproteinases (MMPs) regulate the extracellular matrix in association with various hemorrhagic brain disorders. MMP-9 has been most consistently associated with vascular wall instability and hemorrhagic brain disorders. Doxycycline, a non-specific MMP inhibitor, may enhance vascular stability, thus reducing the risk of spontaneous hemorrhage in brain vascular malformations by decreasing MMP-9 activity.

Completed14 enrollment criteria

Clevidipine for Vasospasm After Subarachnoid Hemorrhage (SAH)

Subarachnoid HemorrhageCerebral Aneurysm2 more

Vasospasm occurs frequently after aneurysmal subarachnoid hemorrhage and can lead to strokes. The investigators will investigate if infusion of a novel drug, clevidipine, will decrease vasospasm during the infusion and post infusion period using transcranial doppler monitoring of patients with subarachnoid hemorrhage and moderate severity vasospasm

Withdrawn21 enrollment criteria

Canadian eCLIPs™ Safety and Feasibility Study Protocol

Intracranial Aneurysms

The purpose of this study is to evaluate the safety and feasibility of the eCLIPs™ Family of Products for the treatment of unruptured intracranial bifurcation aneurysms in conjunction with embolization coils.

Withdrawn23 enrollment criteria

Canadian Study of the MicroVention Flow Re-Direction (FRED) Endoluminal Device Stent System in the...

Intracranial Aneurysms

The study objective is to evaluate the safety and effectiveness of the MicroVention FRED System when used in the treatment of wide-necked intracranial aneurysms.

Withdrawn23 enrollment criteria
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