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Active clinical trials for "Brain Ischemia"

Results 111-120 of 342

: External Shunt Versus Internal Shunt for Off Pump Glenn

Cerebral Ischemia

A prospective, randomized comparative study where investigators present results of off pump bidirectional Glenn operation done using either a venoatrial shunt or external shunt to decompress superior vena cava during clamping.

Completed10 enrollment criteria

Neuroprotective Goal Directed Hemodynamic Optimization in Post-cardiac Arrest Patients

Cerebral IschemiaCardiac Arrest

The primary objective of the Neuroprotect trial is to assess whether or not a new goal directed hemodynamic optimization strategy can reduce cerebral ischemia in post-cardiac arrest (CA) patients.

Completed14 enrollment criteria

Hypoxic-Ischemic Encephalopathy Therapy Optimization in Neonates for Better Neuroprotection With...

Hypoxic-Ischaemic EncephalopathyPerinatal Asphyxia1 more

This is a Phase I, open-label, single center trial to evaluate the feasibility and safety of low concentration CO2 gas mixture (5% CO2 + 95% air) inhalation in asphyxiated, cooled, mechanically ventilated newborns at risk of hypocapnia with The hypothesis is that hypocapnia, which is driven by hyperventilation in the presence of metabolic acidosis, is deleterious to the injured brain and can be safely avoided with low concentration CO2 inhalation.

Completed16 enrollment criteria

Autologous Cord Blood Cell Therapy for Neonatal Encephalopathy

Neonatal EncephalopathyHypoxic-ischemic Encephalopathy

This is a pilot study to test feasibility and safety of intravenous infusion of autologous umbilical cord blood cells in the first 72 hours after birth if a neonate is born with signs of encephalopathy.

Completed16 enrollment criteria

Telerehabilitation With Aims to Improve Lower Extremity Recovery Post-Stroke

StrokeStroke10 more

The purpose of this study is to examine the feasibility and effectiveness of a lower extremity telerehabilitation protocol with aims to improve lower extremity recovery among community-living stroke survivors across Canada.

Completed13 enrollment criteria

NVD in Hypothermic HIE Neonates

HIE - Perinatal Hypoxic - Ischemic Encephalopathy

Neonatal hypoxic ischemic (HI) injury is an unpredictable neurologic injury with devastating, long term consequences for parents who are expecting a normal child. Hypothermia for 72 hr within 6 hrs of birth improves the combined outcome of death or severe disability, and hypothermia is now standard of care in tertiary centers throughout the world. However, approximately 50% of infants with hypoxic ischemic encephalopathy (HIE) treated with hypothermia still have adverse neurologic outcomes, due to ongoing neuroinflammation and oxidative stress in spite of hypothermia. Further, the majority of HIE infants are insufficient or deficient in a critical neurosteroid, 25(OH)vitamin D, which has been shown to adversely affect outcome after adult stroke. By adding vitamin D to N-acetylcysteine (NAC), an antioxidant, the investigators hypothesized that both drugs would increase glutathione (GSH) concentrations in critical brain areas, mitigate continuing oxidative stress after injury during hypothermia and after rewarming, and improve neurodevelopmental outcomes. This is an open-label, non-randomized, escalating dose, pilot trial to evaluate the disposition and safety of NAC in combination with active vitamin D in neonates who present within 6 hrs of hypoxia ischemia/asphyxial event and received moderate hypothermia to 33 degrees C for 72 hours per routine protocol.

Completed5 enrollment criteria

Field Randomization of Nerinetide (NA-1) Therapy in Early Responders

Acute Cerebral Ischemia

The purpose of this study is to determine whether nerinetide (NA-1) is effective in reducing global disability in patients with acute cerebral ischemia if administered early after symptom onset.

Completed21 enrollment criteria

Preemie Hypothermia for Neonatal Encephalopathy

InfantNewborn8 more

This study is a randomized, controlled trial to assess safety and effectiveness of whole body hypothermia for 72 hours in preterm infants 33-35 weeks gestational age (GA) who present at <6 hours postnatal age with moderate to severe neonatal encephalopathy (NE). The study will enroll infants with signs of NE at 18 NICHD Neonatal Research Network sites, and randomly assign them to either receive hypothermia or participate in a non-cooled control group.

Completed18 enrollment criteria

Arm Rehabilitation Study After Stroke

StrokeBrain Infarction3 more

This study is about arm and hand recovery after a stroke. The investigators are testing an experimental arm therapy called Accelerated Skill Acquisition Program (ASAP) which combines challenging, intensive and meaningful practice of tasks of the participant's choice compared to two standard types of therapy (usual and customary arm therapy totaling 30 hours and usual and customary arm therapy for a duration indicated on the therapy prescription). A second objective is to characterize current outpatient arm therapy (dosage & content) following stroke for individuals who are eligible for ICARE. Eligible candidates must have had a stroke affecting an arm within the last 106 days.

Completed15 enrollment criteria

Cord Blood for Neonatal Hypoxic-ischemic Encephalopathy

Neonatal Hypoxic Ischemic Encephalopathy

This is a pilot study to test feasibility of collection, preparation and infusion of a baby's own (autologous)umbilical cord blood in the first 14 days after birth if the baby is born with signs of brain injury.

Completed14 enrollment criteria
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