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Active clinical trials for "Brain Neoplasms"

Results 971-980 of 1541

Randomized Trial Comparing Radiosurgery With vs Without Whole Brain Radiotherapy

Brain Cancer

The goal of this clinical research study is to learn if your thinking ability (cognitive function) will be better preserved by delivering whole brain radiation therapy immediately after radiosurgical treatment of 1-3 brain metastases or to carefully observe patients after radiosurgery and hold back whole brain radiation therapy until the disease comes back.

Completed3 enrollment criteria

Neurobehavioral Functioning in Pediatric Brain Tumor Patients After Proton Beam Radiation Treatment...

Brain TumorCentral Nervous System Neoplasms

The aim of this study is to follow up with all of the pediatric brain tumor patients who received proton beam radiation therapy at Massachusetts General Hospital (MGH) for which there is baseline neuropsychological testing in order to measure changes, if any, in neurobehavioral functioning (executive skills, emotional/behavioral functioning, and adaptive abilities) and their use of special education services at one year or more post-treatment. The investigators will also correlate neurobehavioral data with pertinent clinical information. Participation will be maximized through the use of mail-in, parental- and self-report questionnaires.

Active9 enrollment criteria

Tomotherapy as Primary Radiotherapy for Multipule Brain Metastases

Brain Metastases

This clinical trial was designed to investigate the efficiency and toxicity of tomotherapy as primary radiotherapy for multiple brain metastases.

Completed0 enrollment criteria

Radiomic Analysis for Predicting Treatment Response and Clinical Outcomes in Malignancies

Breast CancerHead and Neck Cancer2 more

In this study, the investigators aim to undertake a retrospective analysis of CT and MRI scans for patients undergoing radiation treatment to develop radiomic signatures to predict treatment response and clinical outcomes.

Active3 enrollment criteria

Multiple Dose Study of MPC-6827 in Subjects With Refractory Brain Metastases

Brain Neoplasms

Phase 1, Multiple dose Study of MPC-6827 in Subjects with Refractory Brain Metastases.

Completed13 enrollment criteria

Neurosurgical Use of Interstitial Laser Therapy (ILT)

Brain Tumor

The researchers' specific aims are to test the following hypotheses: Hypothesis 1: A tumor can be completely ablated by ILT with MRI-guidance. Hypothesis 2: The MRI-based 3D temperature map of tissue during ILT is predictive of destruction. Hypothesis 3: The 3D "thermal dose" map that is based on the tissue's temperature over time is more predictive of tissue destruction than the temperature map.

Completed8 enrollment criteria

Palliative 4pi Radiotherapy in Treating Patients With Recurrent Glioblastoma Multiforme

GlioblastomaRecurrent Brain Neoplasm

This pilot clinical trial studies the feasibility of palliative 4pi radiotherapy in treating patients with glioblastoma multiforme that has come back after standard chemoradiation. A new radiotherapy delivery planning system, called 4pi radiotherapy, may help improve radiation delivery by improving dose coverage to the treatment target, while reducing the dose to surrounding normal tissues.

Completed12 enrollment criteria

Coping With Glioblastoma: A Study of Communication Between Physicians, Patients, and Caregivers...

Brain CancerGlioblastoma

The purpose of this study is to learn more about the way physicians communicate with brain tumor patients. This study will look at how oncologists provide information about brain tumors, brain scan results, and treatment options. This study will look at how oncologists provide information about brain tumors, brain scan results, and treatment options. Ultimately, the investigators hope to use these findings to improve communication between patients, caregivers and their doctors.

Active16 enrollment criteria

The Use of Fentanyl in General Anesthesia for Craniotomy With or Without 0.5% Levobupivacaine Scalp...

Brain Tumor

This study evaluates the use of fentanyl during craniotomy in two groups of brain tumor patients. The control group will receive standard general anesthesia with the use of fentanyl for intraoperative pain control and the study group will receive scalp nerve block with 0.5% levobupivacaine (local anesthetic) and also fentanyl for intraoperative pain control. The scalp nerve block might reduce the dose of fentanyl and promote faster emergence from general anesthesia.

Completed6 enrollment criteria

Intraoperative Goal Directed Fluid Management in Supratentorial Brain Tumor Craniotomy

Brain TumorCraniotomy

Pulse pressure variation (PPV) to standard fluid management (4ml/Kg/hr) in patients undergoing supratentorial mass excision. The investigators hypothesize that in these procedures, goal-directed fluid therapy (GDT) might improve brain relaxation, and patient hemodynamics intra and postoperatively.

Completed2 enrollment criteria
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