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Active clinical trials for "Endometrial Neoplasms"

Results 241-250 of 990

CPI-006 Alone and in Combination With Ciforadenant and With Pembrolizumab for Patients With Advanced...

Non-Small Cell Lung CancerRenal Cell Cancer11 more

This is a Phase 1/1b open-label, dose escalation and dose expansion study of CPI-006, a humanized monoclonal antibody (mAb) targeting the CD73 cell-surface ectonucleotidase in adult subjects with select advanced cancers. CPI-006 will be evaluated as a single agent, in combination with ciforadenant (an oral adenosine 2A receptor antagonist), in combination with pembrolizumab (an anti-PD1 antibody), and in combination with ciforadenant and pembrolizumab.

Active10 enrollment criteria

COM701 (an Inhibitor of PVRIG) in Subjects With Advanced Solid Tumors.

Advanced CancerOvarian Cancer8 more

This is a Phase 1 open label sequential dose escalation and cohort expansion study evaluating the safety, tolerability and preliminary clinical activity of COM701 as monotherapy and in combination with nivolumab.

Active17 enrollment criteria

Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to the Usual Radiation Treatment...

Endometrial Endometrioid AdenocarcinomaStage I Uterine Corpus Cancer AJCC v81 more

This phase III trial compares whether the addition of pembrolizumab to radiation therapy is more effective than radiation therapy alone in reducing the risk of cancer coming back (recurrence) in patients with newly diagnosed stage I-II endometrial cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. The addition of pembrolizumab to radiation treatment may be more effective than radiation treatment alone in reducing cancer recurrence.

Active41 enrollment criteria

A Study of Ketogenic Diet in Newly Diagnosed Overweight or Obese Endometrial Cancer Patients

Endometrial Cancer

The purpose of this study is to test any good and bad effects of an experimental diet, called a ketogenic diet, in endometrial cancer. A ketogenic diet is one that is very low in carbohydrates (simple and complex sugars). The goal of this diet is for the body to go into a state of ketosis. Ketosis is when the body does not have enough sugar for energy so it burns stored fats which create acids called ketones, which can be used for energy. Researchers hope to learn whether or not a ketogenic diet is well-tolerated and safe to eat before surgery in endometrial cancer patients.

Active55 enrollment criteria

Study of AK112 in the Treatment of Advanced Gynecological Tumors

Gynecologic CancerCancer Metastatic3 more

A phase II study to evaluate the efficacy and safety of AK112 in subjects with advanced gynecological tumors.

Active29 enrollment criteria

A Study of SGN-STNV in Advanced Solid Tumors

CarcinomaNon-Small Cell Lung11 more

This trial will look at a drug called SGN-STNV to find out whether it is safe for patients with solid tumors. It will study SGN-STNV to find out what its side effects are. A side effect is anything the drug does besides treating cancer. It will also study how well SGN-STNV works to treat solid tumors. The study will have two parts. Part A of the study will find out how much SGN-STNV should be given to patients. Part B will use the dose found in Part A to find out how safe SGN-STNV is and if it works to treat certain types of solid tumors.

Active28 enrollment criteria

ZW25 in Women With Endometrial Cancers

Endometrial CancerCarcinosarcoma

This study is being done to test the drug ZW25 and look at whether this drug is effective in women with HER2-overexpressed endometrial cancer or carcinosarcoma that has been treated in the past.

Active57 enrollment criteria

The Efficacy and Safety of the Postoperative Adjuvant Treatment in Patients With High-risk Stage...

Endometrial Neoplasms

This randomized trial is studying the efficacy and safety of the chemotherapy compared with radiation therapy alone as adjuvant treatment after operation in Patients with high risk and Stage I endometrial carcinoma.

Active13 enrollment criteria

Safety, Tolerability & Potential Anti-cancer Activity of Increasing Doses of AZD5363 in Different...

Advanced Solid MalignancySafety and Tolerability12 more

This study is designed to investigate the safety and tolerability of a new drug, AZD5363, in patients with advanced cancer - and to identify a dose and schedule that can be used in the future. This study will also investigate how the body handles AZD5363 (ie, how quickly the body absorbs and removes the drug). This study will also investigate anti-tumour activity of AZD5363 in patients with advanced / metastatic breast, gynaecological cancers or other solid cancers bearing either AKT1 / PIK3CA or PTEN mutation.

Active10 enrollment criteria

Randomized Trial of Radiation Therapy With or Without Chemotherapy for Endometrial Cancer

Endometrial Cancer

RATIONALE: Drugs used in chemotherapy, such as cisplatin, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving chemotherapy and radiation therapy after surgery may kill any tumor cells that remain after surgery. It is not yet known whether giving chemotherapy together with radiation therapy is more effective than giving radiation therapy alone in treating endometrial cancer. PURPOSE: This randomized phase III trial is studying chemotherapy and radiation therapy to see how well they work compared with radiation therapy alone in treating patients with high-risk, stage I, stage II, or stage III endometrial cancer.

Active23 enrollment criteria
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