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Active clinical trials for "Gastrointestinal Neoplasms"

Results 161-170 of 614

Targeted Alpha-Particle Therapy for Advanced SSTR2 Positive Neuroendocrine Tumors

Neuroendocrine TumorsNeuroendocrine Tumor of the Lung7 more

This study is Phase I/IIa First-in-Human Study of [212Pb]VMT-α-NET Targeted Alpha-Particle Therapy for Advanced SSTR2 Positive Neuroendocrine Tumors

Not yet recruiting39 enrollment criteria

the Effect of ABCC2 Genetic Polymorphism on Neurotoxicity in Gastrointestinal Cancer Patients Receiving...

Gastrointestinal Cancer

Study the effect of genetic polymorphism (rs1885301, rs4148396 and rs3740066) in the membrane of Multidrug resistance protein 2 (MRP2) encoded by ATP-binding cassette C2 (ABCC2) gene and its genetic expression levels on neurotoxicity in gasrtointestinal cancer patients reciving Oxaliplatin-based chemotherapy.

Recruiting8 enrollment criteria

Effects of Different Doses of Vitamin D on Cancer-related Cognitive Impairment in Patients With...

Gastrointestinal NeoplasmsCognitive Impairment

To explore the effect of different doses of vitamin D drugs on gastrointestinal cancer cancer-related cognitive impairment, so as to provide reference and basis for the clinical use of our cognitive function surgery nursing plan for patients with gastrointestinal cancer.

Not yet recruiting12 enrollment criteria

Real World Treatment Experience of Patients With Breast, Lung, or GI Cancer or Multiple Myeloma...

Breast CancerLung Cancer2 more

The Carevive registry collects patient characteristics, patient symptoms, and treatment experience data from patients receiving cancer treatment for breast, lung, GI or multiple myeloma. For this study, a core set of variables is collected on each patient in the Carevive platform. Patients will complete a baseline survey in person using a secured device or remotely using their own electronic device in a location of their choice. Weekly electronic Patient Reported Outcome surveys are collected from the patients using the Carevive platform for a minimum of 12 weeks. Patients may continue weekly surveys as long as they are receiving treatment.

Recruiting9 enrollment criteria

Prospective Data Registry and Quality of Life Assessment of Patients Undergoing Radiotherapy With...

CancerCancer Central Nervous System8 more

The purpose of this prospective cohort study is to assess clinical and quality of life measures as well as to define the severity of adverse effects for the use of the RefleXion system to deliver intensity-modulated radiotherapy (IMRT), stereotactic body radiotherapy (SBRT), in standard of care (SOC) use in the treatment of local,loco-regionally advanced, and oligometastatic malignancies. In addition, patient costs and charges will be analyzed to quantify the health economic impact of this modality. Workflow and quality of radiotherapy planning including a collection of dosimetric data will also be analyzed.

Recruiting8 enrollment criteria

Optimizing and Personalising Azacitidine Combination Therapy for Treating Solid Tumours QPOP and...

Solid TumorGastrointestinal Cancer1 more

This pilot feasibility study aims to set the foundation to investigate the applicability of QPOP drug selection followed by CURATE.AI-guided dose optimisation of the selected azacitidine combination therapy for solid tumours using CURATE.AI within the current clinical setting. QPOP will identify drug interactions towards optimal efficacy and cytotoxicity from the pre-specified drug pool based on ex vivo experimental data from the individual participant's tissue sample model. With these drug interactions, QPOP will identify the optimal drugs for the specific participant whose biopsy provided the cells for the ex vivo experimentation. Subsequently, CURATE.AI will be used to guide dosing for the selected combination therapy for that participant. Individualised CURATE.AI profiles will be generated based on each participant's response to a set of drug doses. Subsequently, the personalised CURATE.AI profile will be used to recommend the efficacy-driven dose. CURATE.AI will operate only within the safety range for each drug pre-specified for each participant. This pilot feasibility study will inform the investigators on the logistical and scientific feasibility of performing a large-scale randomised controlled trial (RCT) with the selected azacitidine combination therapy regimens and response markers. A secondary objective is to collect toxicity and efficacy data using established and exploratory response markers within and in-between cycles as exploratory outcomes.

Not yet recruiting17 enrollment criteria

Prospectively Predict the Efficacy and Explore the Mechanism of Treatment of Gastrointestinal Tumors...

Advanced or Late Stage Gastrointestinal Cancer

Dynamic multiomics detection of plasma derived exosomes to explore the efficacy and mechanism of anti-HER2, immunotherapy and anti-CLDN18.2 of gastrointestinal cancer.

Recruiting22 enrollment criteria

Phase II Study of Reuse of Oxaliplatin Hypersensitivity in Gastrointestinal Tumors

Gastrointestinal Tumors

The incidence of oxaliplatin allergy reactions is between 12-15%, while the incidence of severe (grade 3-4) allergic reactions is between 0.5-2%. The purpose of this study is to prospectively investigate the incidence of oxaliplatin allergy and neurotoxicity, and to evaluate the use of effective anti-allergic and desensitization therapies to enable patients who are already allergic to oxaliplatin to complete their prescribed doses smoothly.

Not yet recruiting6 enrollment criteria

Rare Subtypes of Gastrointestinal Cancers

Cancer of Gastrointestinal Tract

A single-arm prospective observational translational study of biomarkers in patients receiving targeted treatment for rare subtypes of cancer of the Gastrointestinal Tract.

Recruiting8 enrollment criteria

Resilience and Equity in Aging, Cancer, and Health (REACH)

Gastric CancerColon Cancer4 more

The purpose of this multi-phase research study is to understand how consultation of cancer care with a geriatrician can best improve outcomes for older adults with gastrointestinal malignancies.

Recruiting9 enrollment criteria
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