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Active clinical trials for "Candidemia"

Results 1-10 of 61

Comparison of Uncomplicated Candidemia Therapy Duration in Children

Invasive Candidiasis

The goal of this clinical trial is to compare antifungal therapy duration in pediatric uncomplicated candidemia. The specific aims are: Compare the desirability of outcome ranking in children with uncomplicated candidemia randomized to 7 additional days of antifungal therapy (standard-course) versus no additional antifungal therapy (short-course) after already receiving 7 days of echinocandin therapy. Compare the 14-day desirability of outcome measure for subjects with a negative and those with a positive T2Candida® biomarker at day 7 of therapy within randomized groups. Participants meeting eligibility criteria will be approached and consented between day 5 and 7 of primary systemic antifungal therapy. On day 7 of primary systemic antifungal therapy, inclusion and exclusion criteria will again be reviewed for consented patients and those still eligible will be randomized 1:1 to the two study arms. Researchers will compare no additional antifungal therapy (short-course) versus 7 additional days of systemic antifungal therapy (standard-course) in pediatric patients with uncomplicated candidemia who have already received 7 days of primary systemic antifungal therapy to see if shorter durations are as effective as longer durations in treating uncomplicated candidemia.

Recruiting11 enrollment criteria

Safety and Efficacy of Interferon-Gamma 1b in Patients With Candidemia

Candidemia

A multi-center open label adaptive randomized interventional phase 2 study to evaluate safety and efficacy of rIFN-y treatment in patiens with candidemia.

Recruiting24 enrollment criteria

A Phase 3, Randomized, Double-blind Study for Patients With Invasive Candidiasis Treated With IV...

CandidiasisInvasive1 more

This is a multicenter, randomized, double-blind study of two treatment regimens for invasive candidiasis included candidemia. Subjects will receive intravenous echinocandin followed by oral ibrexafungerp (SCY-078) vs intravenous echinocandin followed by oral fluconazole.

Recruiting20 enrollment criteria

Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal...

CandidemiaMycoses8 more

The purpose of this pivotal study is to determine if intravenous Rezafungin is efficacious and safe in the prevention of invasive fungal diseases when compared to the standard antimicrobial regimen.

Recruiting61 enrollment criteria

A Study to Learn About the Study Medicine (Called Fosmanogepix/ PF-07842805) in People With Candidemia...

CandidemiaCandidiasis1 more

The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called Fosmanogepix) for the potential treatment of candidemia and/or invasive candidiasis, a life-threatening fungal infection caused by several species of yeast called Candida. The study is seeking participants who have a diagnosis of candidemia or invasive candidiasis. Two-thirds of all participants will receive the study medication fosmanogepix Intravenous (IV) infusion followed by optional fosmanogepix tablets. One-third of all participants will receive a standard of care regimen of caspofungin Intravenous (IV) infusion followed by optional fluconazole capsules. Fosmaogepix or caspofungin will first be given as an Intravenous (IV) infusion directly into a vein in the arm each day at the study clinic. Fosmaogepix tablets or fluconazole capsules will be taken orally by mouth daily either at the study clinic, or at home if participants are well enough to be discharged from the hospital. We will compare the experience of people receiving fosmanogepix to those receiving caspofungin/ fluconazole. This will help us determine if fosmanogepix is safe and effective. Participants will continue treatment for a maximum of 6 weeks depending on whether the infection has cleared and whether the symptoms related to the infection has improved. During this time, they will have study visits for up to 10 times. There will also be a follow-up visit 6 weeks after the study treatment was stopped.

Not yet recruiting6 enrollment criteria

A Study to Evaluate the Efficacy and Safety of Micafungin Against Invasive Candidiasis or Candidemia...

CandidemiaCandidiasis

To evaluate the efficacy and safety of intravenous micafungin for the treatment of patients with proven or probable fungal infections caused by Candida sp. (Fungemia, respiratory mycosis, gastrointestinal mycosis) in adult patients in China.

Terminated10 enrollment criteria

Study of Rezafungin Compared to Caspofungin in Subjects With Candidemia and/or Invasive Candidiasis...

CandidemiaMycoses2 more

The purpose of this pivotal study is to determine if intravenous Rezafungin is efficacious and safe in the treatment of candidemia and/or invasive candidiasis when compared to caspofungin (followed by optional oral fluconazole).

Completed31 enrollment criteria

An Open-label Study of APX001 for Treatment of Patients With Candidemia/Invasive Candidiasis Caused...

CandidemiaInvasive Candidiases1 more

This is a multicenter, open-label, single arm study to evaluate the efficacy and safety of APX001 for the treatment of candidemia and/or invasive candidiasis caused by C. auris in patients aged 18 years and over with limited antifungal treatment options.

Completed13 enrollment criteria

Anidulafungin In Treatment Of Candidemia In Asian Subjects

Candidemia

The purpose of this study is to determine whether or not the Investigational Study Drug anidulafungin is safe and effective in the treatment of a fungal infection, candidemia, in Asian subjects.

Completed7 enrollment criteria

Isavuconazole (BAL8557) in the Treatment of Candidemia and Other Invasive Candida Infections

CandidiasisInvasive2 more

The purpose of the study is to compare the safety and efficacy of isavuconazole versus caspofungin followed by voriconazole in the treatment of candidemia and other invasive Candida infections.

Completed7 enrollment criteria
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