Anidulafungin Pharmacokinetics in Intensive Care Unit Patients
Invasive CandidiasisCandidemiaThe purpose of this study is to determine the pharmacokinetics of anidulafungin in intensive care patients.
Evaluate the Performance of Genetic Amplification by Polymerase Chain Reaction (PCR) and the "Mannan...
Invasive Candidiasis; Treatment With EchinocandinThe study consists in taking 4 tubes of blood at different times over a period of 10 days, via a catheter (central venous or arterial catheter) already in place in the usual therapeutic management. These samples will make it possible to measure blood levels of certain markers specific to invasive candidiasis. PCR will be used to quantify fungal load precisely, that is to say the quantity of yeast present in the blood and to monitor this quantity over time. These samples will be transferred to a specialized unit and stored for a maximum of three years for use at the end of the study.
A B-D-Glucan Driven Antifungal Stewardship Approach for Invasive Candidiasis
Invasive CandidiasesAbdominal InfectionThis is a multicenter, prospective, open-label, randomized trial. Patients with severe abdominal condition developing severe sepsis or septic shock and receiving broad spectrum antibiotic and antifungal treatment will be randomized (1:1) to: discontinue antifungal treatment based on negative (<80 pg/ml) result of 1,3 beta-d-glucan performed on day 0,3,6 and 10 continue antifungal treatment according with attending physician's decision.