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Active clinical trials for "Candidiasis"

Results 231-240 of 273

Research of New Serological Markers for the Diagnosis and Monitoring of Candidaemia in Hospitalized...

Candida Infection

Bloodstream infections due to Candida spp remain a serious medical challenge because of their high incidence and poor outcome. Diagnosis and monitoring of patients are still problematic, hindering efficient clinical management of the disease. The invastigators propose here to perform a retrospective study in a clinically well-characterized candidemic patient, with the goal of recognizing host immunological factors and virulence-associated fungal molecules relevant in the onset and evolution of infection. The researchers' ultimate goal is to identify new diagnostic and/or prognostic benchmarks useful in clinical settings. By combining serologic and immunologic expertise with clinical expertise, the research team has real potential to generate new markers of host pathogenesis and immune response in candidemia and to inform prospective clinical trials to control this terrible disease

Completed8 enrollment criteria

Epidemiological Study in Subjects With Vulvovaginal Candidiases

Vulvovaginal Candidiases

Epidemiological study about the clinical and microbiological progress in subjects under treatment for a severe vulvovaginal candidiases episody

Completed8 enrollment criteria

Impact of a Loading Dose of Caspofungin in Invasive Candidiasis in ICU Patients

Candida Infections

Echinocandins are the drug of choice in severe candida infections. Efficacy of echinocandins is related to concentration and area under the curve (AUC) of the drug. Available pharmacokinetic studies found that concentration of echinocandins mainly caspofungin is sub-optimal in severe candida infections in intensive care unit (ICU) patients. Higher dose of caspofungin has been proven to be safe in critically ill patients but its impact on the ability to reach PK/PD target is unknown. The aim of this study is to evaluate the impact of a loading dose of caspofungin on PK/PD parameters within the first 24-hours.

Completed13 enrollment criteria

Study of the Microbiota, Metabolome, and Environmental Toxins in Relation to Reproductive Health...

Vulvovaginal CandidiasisBacterial Vaginosis

The overall objective of this clinical pilot study is to determine at a random sampling time, the vaginal microbiome and metabolome of pregnant women, and to see if infection (bacterial vaginosis, vulvovaginal candidiasis, malaria) and exposure to environmental toxins affects could alter pregnancy and conception outcomes. It is hypothesized that infection and toxins will alter the vaginal microbiome and metabolome, increasing the risk of preterm labour and infertility in Rwandan women. In a sub-group of subjects, a preliminary assessment of the ability of orally administered probiotic lactobacilli to restore the vaginal microbiota to a healthy state and lower environmental toxins will be completed.

Completed2 enrollment criteria

Immunological Interaction Between the Host and Candida Albicans Biofilm

Candidiasis

Candida albicans is one of the most common nosocomial infection and the onset relies on the host immune status. The purpose of this study is to determine the immunological profile of patients infected with Candida albicans, that could ideally lead to a strategy to identify patients who could benefit from prophylaxis.

Completed5 enrollment criteria

Antimycotic Prophylaxis in Pediatric Patients Following Allogeneic Stem Cell Transplantation

Systemic AspergillosisSystemic Candidiasis

Pediatric patients are at high risk to acquire mycotic infections following allogeneic bone marrow transplantation. In the present retrospective analysis we assess the safety and efficacy of different regimens in antimycotic prophylaxis.

Completed5 enrollment criteria

Study of Antibiotic-induced Vaginal Yeast Infections in Healthy Women

MicrobiomeAntibiotic-Induced VVC1 more

Background: - Vaginal yeast infections are caused by a fungus called Candida. Candida can live harmlessly in the vagina, but most women will have symptoms from a vaginal yeast infection at some point during their life. Antibiotics increase the risk for yeast infections, but it is unclear why. They may disrupt the balance of healthy bacteria in the vagina. This could make it harder for the body to fight off yeast infections. Researchers will give healthy women a common antibiotic or a placebo. They will study how the antibiotic affects bacteria and yeast in the vagina and other parts of the body. This will let researchers study the normal changes of healthy bacteria and yeast over time. Objectives: - To see how the study drug changes healthy bacteria in the vagina, and how these changes may increase the risk for yeast infections. Eligibility: - Healthy women ages 18 to 40 who are not allergic to penicillin. Design: Participants will be screened with medical history, physical exam (including vaginal exam), blood tests and tests for sexually transmitted diseases. Participants must take birth control pills for at least 3 months before, and during the study. Participants will take the study antibiotic or placebo for 10 days. Participants will have 7 study visits over 3 months. Visits will be timed around participants menstrual cycles. At the visits, participants will answer questions about their health and undergo tests. These may include swabs of the vagina, mouth and skin as well as blood tests. Vaginal fluid, saliva and urine will also be collected. Between visits, participants will collect stool and vaginal samples at home and bring them to the next clinic visit.

Terminated39 enrollment criteria

Incidence of Oral Candidiasis, Prevalence of C. Dubliniensis in HIV Patients and In-vitro Azole...

CandidiasisHIV Infections

C. dubliniensis has been identified as pathogen in Oropharyngeal Candidiasis(OPC)particularly among HIV patients. Azole therapy is a cornerstone in OPC, but resistance within C. dubliniensis isolates to diflucan is common.This is a prospective collection of biological specimens from oropharyngeal cavity with the purpose of determining the prevalence of C. dubliniensis in HIV/AIDS patients at the Duval County Department of Health Comprehensive care Center. It is hereto proposed an estimation of azole-resistance in these isolates.

Terminated2 enrollment criteria

Risk Of Severe Hepatic Injury In Patients With Invasive Candidiasis Treated With Echinocandins

Invasive CandidiasisCandidemia

The purpose of this study is to estimate the relative risk of severe hepatic injury in hospitalized patients with invasive candidiasis and candidemia who received anidulafungin, compared to patients who received caspofungin and/or micafungin.

Terminated11 enrollment criteria

Genetic Susceptibility Factors for Candidemia.

Invasive CandidiasisCandidemia1 more

This is a prospective case-control physiopathological study, which main objective is to determine the genetic host factors predisposing to candidemia. Secondary objectives are to develop new diagnosis tools using the biological collection, to describe and update epidemiology, to analyse the influence of genetic polymorphisms on prognosis.

Completed6 enrollment criteria
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