A Study of Gene Polymorphisms and Normal Tissue Radiation Injury in Patients Treated for Breast,...
Breast CancerGlioma6 moreThis study will examine, for the first time, the independent contribution of a patient's own genetic makeup to the development of post-radiation complications, permitting the future development of predictive tests to avoid radiation injury. To do this, the investigators will examine gene markers in a series of breast, prostate, brain and lung cancer survivors who have received conformal radiotherapy between 1996 and 2003 at the Cross Cancer Institute and Tom Baker Cancer Centre.
Evaluating Mutations in MET and TP53 Among Patients Diagnosed With Squamous Cell Carcinoma
Squamous Cell Carcinoma of the LungSquamous Cell Carcinoma of the Head and NeckThis study focuses on advanced lung and head and neck SCC tumours, with adjacent normal lung tissues. Biopsies will be performed in National University Health System, Singapore (NUHS) as part of participants' standard care. Patient blood was also required for extraction of cell free DNA (cfDNA) and genomic DNA (gDNA). Patients' medical records will also be reviewed for the purpose of this study.
Predictive Value of PET CT in the Histologic Lymph Node Status of Patients With Squamous Cell Carcinoma...
Squamous Cell Carcinoma of the OralClinically Node-Negative and RadiologySquamous cell carcinoma of the VADS represents the majority of cancers in ENT. Metastatic lymph node involvement is an important prognostic factor. In N0 patients clinically and scanographically, the prevalence of cervical lymph node metastasis remains important. Only the anatomopathological analysis of cervical lymph node dissection confirms the presence of a micro-metastasis. However, new criteria of interpretation in nuclear medicine seem promising in the detection of lymph node lesions not detectable in traditional imaging. The main objective of this study is to study the positive predictive value (PPV) of CT scans in the anatomo-pathological analysis of N0 clinical and radiological or N + unilateral neck ganglia in patients with squamous cell carcinoma of the oral cavity.
Developing an In-vitro Diagnostic Risk-Stratification Test for Oral Cancer
Oral Squamous Cell CarcinomaThe purpose of this study is to verify the discriminatory value of previously identified salivary transcriptome and proteome markers for oral squamous cell cancer in an intended use population of patients with oral lesions suspicious for cancer.
Sexual Behavior in Head and Neck Cancer Patients
Oropharyngeal CancerHead and Neck Cancer1 moreThe goal of this behavioral research study is to learn if certain sexual behaviors increase the risk for developing head and neck cancers associated with a virus called human papillomavirus (HPV-16). Knowing this information could help doctors better teach patients about avoiding certain risk factors, which may help to prevent the disease.
Immune Response Evaluation to Curative Conventional Therapy
Head and Neck Squamous Cell CarcinomaThe IRECT trial is a non-interventional, prospective clinical trial using modern immune monitoring techniques over the course of the standard of care for HNSCC. The dynamics of host/tumor immune interactions during the conventional standard treatment will be analyzed to find the most promising target antigen and to develop a strategy how and when specific immunotherapy should be added to the current treatment schedule. The results from this trial will help to understand how state of the art treatment can be complemented using cancer-testis antigen specific vaccines and immune-modulating drugs to improve the outcome of head and neck cancer patients.
Collection of Plasma Samples for Squamous Cell Carcinoma of the Head and Neck Patients
Squamous Cell Carcinoma of the Head and NeckThe investigators will collect plasma samples at baseline, during treatment, and at progression.