Efficacy and Safety of TORS for SCCA
Oropharyngeal Squamous Cell CarcinomaSupraglottic Squamous Cell CarcinomaThe purpose of this study is to learn more about the outcomes of treatment of throat and voice box cancers using transoral robotic surgery (TORS). TORS is a relatively new option involving the use of the da Vinci surgical robot to remove these cancers through the mouth.
HOT: HIPEC in Ovarian Cancer as Initial Treatment
Stage III Ovarian CancerStage IV Ovarian Cancer5 moreCommunity hospital based phase II (prospective randomized) study to evaluate the toxicity of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in newly diagnosed, otherwise untreated, advanced stage (stage III/IV) epithelial ovarian, fallopian tube, and primary peritoneal cancer.
18F-FSPG PET in Imaging Patients With Liver Cancer Before Undergoing Surgery or Transplant
Adult Hepatocellular CarcinomaResectable Hepatocellular Carcinoma3 moreThis clinical trial studies fluorine F 18 L-glutamate derivative BAY94-9392 (18F-FSPG) positron emission tomography (PET) in imaging patients with liver cancer before undergoing surgery or transplant. Diagnostic procedures, such as 18F-FSPG PET, may help find and diagnose liver cancer and find out how far the disease has spread.
Intraoperative Radiotherapy After Local Recurrence in Breast Cancer
Breast CarcinomaThe investigators propose a prospective, multicenter, single arm Phase II design to evaluate the feasibility of repeated breast-conserving surgery combined with re- irradiation using IORT after local recurrence of breast carcinoma.
HARE-40: HPV Anti-CD40 RNA vaccinE
Human Papilloma Virus Related CarcinomaHead and Neck Neoplasm3 moreHARE-40 is a phase I/II vaccine dose escalation study with two different arms: Arm 1A will perform intrapatient dose escalation in patients with previously treated HPV16+ Head & Neck Cancer using two dose cohorts to establish a safe, tolerable and recommended dose of HPV vaccine. Arm 1B will perform intrapatient dose escalation in patients with advanced HPV16+ cancer (head and neck, anogenital, penile, cervical and other) using a single cohort to establish a safe, tolerable and recommended dose of HPV vaccine.
PET/MR in Locally Advanced Nasopharyngeal Carcinoma
Nasopharyngeal CarcinomaPET/MRPET/MR in Locally Advanced Nasopharyngeal Carcinoma
Cell-free Tumor DNA in Head and Neck Cancer Patients
Head and Neck CancerHead and Neck Neoplasms25 moreThis study investigates if head and neck squamous cell carcinoma can be tracked with cell-free tumor DNA, RNA or HPV-DNA, in blood samples from patients referred with suspicion of cancer, and if it can be used in detecting recurrence in patients already diagnosed and treated for head and neck squamous cell carcinoma.
INRT-AIR: A Prospective Phase II Study of Involved Nodal Radiation Therapy
Head and Neck Squamous Cell CarcinomaElective nodal irradiation has been a longstanding standard-of-care in the management of mucosal squamous cell carcinoma of the head and neck. Recent studies have suggested that reduced elective dose and volume may be a viable approach to improve toxicity. In this study, we are eliminating the elective neck treatment, focusing therapy on involved and suspicious nodes.
Screening Algorithms for Cervical and Anal High-Grade Squamous Intraepithelial Lesions in People...
AIDS-Related Anal CarcinomaAIDS-Related Cervical Carcinoma3 moreThis clinical trial aims to find what different tests work best to find high-grade squamous intraepithelial lesions (HSIL) in the cervix or anus in patients living with human immunodeficiency virus (HIV). Patients with HIV are at high risk of becoming infected with human papillomavirus (HPV) in the cervix or anus where it can turn into cancer over several years. HPV causes changes to the cervix and anus, known as HSIL. This means that there is an area of abnormal tissue on the top layers of the cervix or anus. It is considered cervical or anal cancer if the abnormality spreads down into the layers of tissue below the top. If found early, many cases of HSIL can be treated before turning into cancer. Screening for cervical or anal cancer detection or HSIL associated with HPV may result in earlier treatment, if necessary, for patients living with HIV.
An Investigational Scan (68Ga-PSMA-11 PET/CT) for the Imaging of Prostate Cancer
Biochemically Recurrent Prostate CarcinomaCastration-Resistant Prostate Carcinoma3 moreThis trial studies how well 68Ga-PSMA-11 PET/CT scan works in imaging patients with prostate cancer. Diagnostic procedures, such as 68Ga-PSMA-11 PET/CT may find and diagnose prostate cancer and improve monitoring of treatment response.