search

Active clinical trials for "Cardiomyopathies"

Results 1-10 of 1105

A Study to Evaluate the Efficacy, Safety, and Tolerability of MYK-224 in Participants With Symptomatic...

CardiomyopathyHypertrophic

The purpose of this study is to characterize the safety, tolerability, efficacy, pharmacokinetics (PK), and pharmacodynamics (PD) of MYK-224 in participants with obstructive Hypertrophic Cardiomyopathy (oHCM)

Recruiting24 enrollment criteria

LBBP as Initial Therapy in Patients With Non-ischemic Heart Failure and LBBB

Non-ischemic CardiomyopathyHeart Failure1 more

The present study will recruit 50 symptomatic non-ischemic cardiomyopathy (NICM) patients with left ventricular ejection fraction (LVEF) below 35% and complete left bundle branch block (CLBBB), who have not received complete guideline-directed medical therapy (GDMT). Each patient was randomized to 2 groups, GDMT or left bundle branch pacing combined with GDMT (LBBP+GDMT) as initial therapy and was followed up for 2 phases: 0-6 months (phase I), 7-18 months (phase II). The primary objective is to compare the LVEF change , syncope and malignant ventricular arrhythmias between GDMT group and LBBP+GDMT group, and to observe which strategy will significantly reduce the percentage of recommendations for an implantable cardioverter-defibrillator (ICD) during phase I study. The second outcome measures including health economics, echocardiography parameters[left ventricular ejection fraction (LVEF), left ventricular end-systolic volume (LVESV), left ventricular end-diastolic volume (LVEDV)], N-terminal pro B-type natriuretic peptide (NT-proBNP) level, New York Heart Association (NYHA) class, 6-minute walking distance (6MWD), quality of life score(QOL) and incidence of clinical adverse events.

Recruiting14 enrollment criteria

The Effects of Hydroxychloroquine in Patients With Inflammatory Cardiomyopathy

Inflammatory CardiomyopathyMyocarditis

Evaluating the long-term therapeutic effects of hydroxychloroquine(compared to glucocorticoid therapy alone) in patients with inflammatory cardiomyopathy--a multicenter randomized controlled study

Recruiting13 enrollment criteria

Myocardial Telomere Recapping Study for Dilated Cardiomyopathy

Heart FailureDilated Cardiomyopathy

The aim of this study is to determine the safety and feasibility of giving an adeno-associated viral vector expressing a modified telomerase protein (TERT), driven by cardiac troponin T promoter (AAV9-cTnT-modTERT), to 15 dilated cardiomyopathic patients.

Recruiting31 enrollment criteria

Revascularization Versus Medical Treatment in Patients With Ischemic Left Ventricular Dysfunction...

Heart Failure With Reduced Ejection FractionIschemic Cardiomyopathy

Randomized trial to compare clinical outcomes between revascularization versus medical treatment alone in patients with ischemic cardiomyopathy and left ventricular dysfunction.

Recruiting14 enrollment criteria

Donor Bone Marrow Derived Mesenchymal Stem Cells in Controlling Heart Failure in Patients With Cardiomyopathy...

CardiomyopathyHeart Failure2 more

This randomized pilot phase I trial studies the side effects of donor bone marrow derived mesenchymal stem cells in controlling heart failure in patients with cardiomyopathy caused by anthracyclines. Donor bone marrow derived mesenchymal stem cells may help to control symptoms of heart failure and improve heart function.

Recruiting26 enrollment criteria

Use of Bone Marrow Derived Stem Cell and G-CSF With Circulatory Assistance in the Treatment of DCM...

Dilated Cardiomyopathy

DCM Support is recruiting patients with dilated cardiomyopathy and heart failure symptoms. The goal of this clinical trial is to examine whether treatment with a patient's own stem cells can improve their heart function and alleviate heart failure symptoms. Stem cells will be collected from bone marrow in the patient's hip under local anaesthetic. The stem cells will be infused into the arteries that supply blood to the heart under local anaesthetic. A mini heart pump will be used to take the strain off the heart during the procedure. The follow-up involves a phone call at 1 month and clinic visits at 3 and 12 months

Recruiting24 enrollment criteria

Oral Ifetroban in Subjects With Duchenne Muscular Dystrophy

Duchenne Muscular Dystrophy CardiomyopathyCardiomyopathy1 more

Duchenne muscular dystrophy (DMD) is a devastating X-linked disease which leads to loss of ambulation between ages 7 and 13, respiratory failure and cardiomyopathy (CM) at any age, and inevitably premature death of affected young men in their late twenties. DMD is the most common fatal genetic disorder diagnosed in childhood. It affects approximately 1 in every 3,500 live male births across all races and cultures, and results in 20,000 new cases each year worldwide.Significant advances in respiratory care have unmasked CM as the leading cause of death. As there are yet no specific cardiac treatments to extend life, the current study aims to address this unmet medical need using a new therapeutic strategy for patients with DMD. Funding Source - FDA OOPD

Recruiting19 enrollment criteria

Ablation at Virtual-hEart pRedicted Targets for VT

Ventricular TachycardiaIschemic Cardiomyopathy

The goal of this study is to test the efficacy of the new imaging/simulation ("virtual heart") approach for determining the optimal ablation sites in patients with VT, which render post-infarction VT non-inducible. The study will test both the acute outcome of the ablation procedure, and the effect the use of the predicted targets has upon procedure time.

Recruiting8 enrollment criteria

Bisoprolol in DMD Early Cardiomyopathy

Duchenne Muscular DystrophyCardiomyopathy1 more

This study aimed to use cardiac magnetic resonance imaging (CMR) to evaluate the efficacy and safety of bisoprolol therapy for boys with Duchenne muscular dystrophy(DMD) and preserved ejection fraction. On top of angiotensin-converting enzyme inhibitor (ACEI) , half of the participants will receive bisoprolol in combination, while the other half will not receive any beta-blocker.

Recruiting17 enrollment criteria
12...111

Need Help? Contact our team!


We'll reach out to this number within 24 hrs