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Active clinical trials for "Cardiotoxicity"

Results 181-190 of 209

Cardiac Toxicity in Medical Treatment of Breast Cancer

Heart FailureBreast Cancer

This study will describe the epidemiology including prognosis of heart failure related to treatment with anthracycline and trastuzumab for breast cancer. In a prospective study Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer patients scheduled for trastuzumab treatment at Odense University Hospital, will be offered advanced echocardiographic examination, test of bio-markers and genetic markers for the purpose of investigating if early identification of patients in particular risk of developing heart failure is feasible.

Completed5 enrollment criteria

Usefulness of Myocardial Deformation Imaging for Trastuzumab-induced Cardiotoxicity

Left Ventricular Function Systolic DysfunctionCardiotoxicity

Trastuzumab prolongs survival in patients with human epidermal growth factor receptor type 2-positive breast cancer. Sequential left ventricular (LV) ejection fraction (EF) assessment has been mandated to detect myocardial dysfunction because of the risk of heart failure with this treatment. Myocardial deformation imaging is a sensitive means of detecting LV dysfunction, but this technique has not been evaluated in patients treated with trastuzumab. The aim of this study was to investigate whether changes in tissue deformation, assessed by myocardial strain and strain rate (SR), are able to identify LV dysfunction earlier than conventional echocardiographic measures in patients treated with trastuzumab.

Completed6 enrollment criteria

Cardiac Fibrosis and Risk Prediction in Cancer Treatment-Related Cardiotoxicity

Cardiotoxicity

The purpose of this study is to determine whether pre-existing cardiac fibrosis is a predictor of cancer treatment-related cardiotoxicity.

Completed12 enrollment criteria

Exercise Response After Revalidation in Cancer Patients

OncologyCardiac Toxicity

This study regarding oncological patients for rehabilitation after specific cancer therapy involves three aims: (1) to evaluate the predictive value of myocardial work parameters on the improvement of exercise performance after rehabilitation, (2) to determine which echocardiographic parameters are more suitable in predicting cardiac dysfunction, and (3) to evaluate the correlation between echocardiographic parameters and fibrosis detected by cardiac magnetic resonance imaging (CMR).

Unknown status10 enrollment criteria

Association Between Telomere Length and Cardiac Dysfunction

Cardiac ToxicityAcute Leukemia1 more

Compelling epidemiological evidence indicates that alterations of relative telomere length (RTL) are associated with cardiac dysfunction caused by chemotherapy in children with acute leukemia (AL).The aim of this study was to explore association between RTL content in peripheral blood cells could be used as a risk predictor for severity of cardiac damage.

Completed2 enrollment criteria

Early Detection of Broken Hearts in Cancer Patients

Cardiotoxicity

The early detection of BVZ or Sunitinib mediated cardiotoxicity using cardiac biomarkers and novel Transthoracic Echocardiogram (TTE) techniques may allow one to adjust treatment and/or administer prophylactic cardioprotective agents, prior to the development of irreversible cardiac dysfunction. We hypothesize that cardiac biomarkers, TVI/strain-derived indices will be able to accurately detect subtle cardiac injury at a time when conventional Left Ventricular Ejection Fraction (LVEF) remains normal in BVZ or Sunitinib mediated cardiotoxicity. Additionally, we hypothesize that Endothelial Function Test (EndoPAT) testing can detect early BVZ or Sunitinib mediated endothelial dysfunction.

Completed4 enrollment criteria

Effect of Concomitant Radiotherapy and Trastuzumab on Cardiotoxicity of Patients Treated for Early...

Breast Cancer

The purpose of this study is to determine whether concomitant radiotherapy and trastuzumab (patients treated for early breast cancer) is really safe for the heart even years after treatment and if the investigators should use these two treatments concomitantly without additional harm.

Completed3 enrollment criteria

Detection of Chemotherapy Induced Cardiotoxicity

Cancer

To identify patients that are at risk of heart damage after receiving chemotherapy (adriamycin).

Completed3 enrollment criteria

Evaluation of Myocardial Injury After Anthracycline Chemotherapy in Osteosarcoma Patients Using...

CardiotoxicityOsteosarcoma3 more

using a contrast-enhanced (CE) cardiac magnetic resonance imaging(CMR) which included the measurement of T1 mapping, T2 mapping, T2* mapping and late gadolinium enhancement(LGE) sequences, as well as LVEF and extracellular volume(ECV) to evaluate the respective changes before and after anthracycline chemotherapy.

Unknown status5 enrollment criteria

Evaluation of Heart Function in Breast Cancer Patients Using Trastuzumab

CardiotoxicityAntitumor Drugs2 more

By dynamically observing the changes of echocardiogram and biomarkers in breast cancer patients using trastuzumab, evaluate the effect of trastuzumab on cardiac function; determine the sensitivity of echocardiography and biomarker indicators And specificity, explore effective and specific early warning indicators, and provide technical support for the evaluation of the cardiac safety of anti-tumor drugs.

Unknown status8 enrollment criteria
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