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Active clinical trials for "Uterine Cervical Neoplasms"

Results 1141-1150 of 1335

TRAIL-CC: Trachelectomy, Radical Hysterectomy, and Intimate Life After Cervical Cancer Study

Cervical Cancer

The objective of this study is to compare radical hysterectomy with trachelectomy on outcomes related to intimacy, sexual health, and mood immediately before, 1 month after, and 6 months after surgery.

Completed4 enrollment criteria

Clinical Trial for the Use of a Novel Cell Collector Device to Retrieve Cells From the Uterine Cervix...

Uterine Cervical DysplasiaUterine Cervical Intraepithelial Neoplasia2 more

This study tested the safety and performance of a new cell collector device and compared the results to those obtained with the current existing device that are being used routinely

Completed2 enrollment criteria

Computed Tomotherapy (CT) and Magnetic Resonance Imaging (MRI) Fusion on Radiation Treatment Planning...

Cervix Cancer

Patients with more advanced stages of cervix cancer are treated by radiotherapy. Overall, more than 50% are cured. Approximately half of those patients not cured have current cancer in the irradiated volume. Higher doses of radiation would be expected to cure more patients. To give high doses of radiation safely, the investigators need to know very precisely where the cancer is and then they can use new technology available at the Cross Cancer Institute (tomotherapy) to target the cancer precisely, giving higher doses to the cancerous tissues and lower doses to the non-cancerous tissues. This study of ten patients with cervical cancer will investigate the added value of MRI scanning on precise tumor definition to facilitate more accurate radiotherapy treatment planning. For this study, patients will be treated in the conventional way with conventional doses. The investigators hope that treatment for future patients will be planned with MRI data and that they will be treated to higher doses of tomotherapy.

Completed3 enrollment criteria

The IMAP Study Improving Management of Mildly Abnormal Pap Smears

Cervix Neoplasms

The study compares the psychosocial outcomes of different management strategies for women with minor atypia (including 'HPV effect') detected on Pap smears: conventional management (a repeat Pap smear at 6 months) versus Human papillomavirus (HPV) DNA testing, a new method proposed for the management of minor atypia and the informed choice of either management supported by a decision aid. The study examines women's informed preferences for each of these options and compares the psychosocial outcomes in women who are or are not given the choice of management. HPV DNA testing offers considerable changes to the management of women with minor atypia and there is evidence from the USA which suggests that the use of HPV DNA testing as a triage strategy is effective for women within this group (Solomon et al 2001). The introduction of HPV DNA testing may bring both benefits and harms to women. These harms and benefits are not well understood. Examination of the psychosocial outcomes of HPV DNA testing compared to conventional management and women's preferences for each is needed to guide decisions concerning HPV DNA testing in cervical screening in Australia and also internationally.

Unknown status7 enrollment criteria

MRI and PET Imaging in Predicting Treatment Response in Patients With Stage IB-IVA Cervical Cancer...

Cervical AdenocarcinomaCervical Adenosquamous Carcinoma12 more

This trial studies magnetic resonance imaging (MRI) and positron emission tomography (PET) imaging in predictive treatment response in patients with stage IB-IVA cervical cancer. MRI is a procedure in which radio waves and a powerful magnet linked to a computer are used to create detailed pictures of areas inside the body. PET is a procedure in which a small amount of radioactive glucose (sugar) is injected into a vein, and a scanner is used to make detailed, computerized pictures of areas inside the body where the glucose is taken up. Comparing results of diagnostic procedures, such as MRI and PET, done before, during and after radiation and chemotherapy may help doctors predict a patient's response to treatment and help plan the best treatment.

Terminated12 enrollment criteria

Cervical Cancer Screening Project Part C

Cervical Cancer

This proposal has been developed through collaboration between the University of Minnesota and New American Community Services (NACS), and the research design is based on a needs assessment conducted by the community partner. The investigators will test the hypotheses that women who are offered home vaginal bio-specimen collection will have higher rate of cervical cancer screening completion than that of women referred for clinic-based Pap test. All participants will be given identical education materials on cervical cancer screening and HPV, currently in use by the Minnesota Sage Program.

Terminated7 enrollment criteria

A Prospective Study Examining the Barriers to Care for Harris County Cervical Cancer Patients

Cervical Cancer

The goal of this behavioral research study is to look at the reasons that may prevent women from getting early treatment for their cervical cancer.

Terminated2 enrollment criteria

New Indications for Ultrasound in the Staging of Cervical Cancer

Cervical Cancer

The purpose is to investigate and evaluate two new diagnostic methods using ultrasound in the staging of cervical cancer. 3-D-ultrasound of the tumour to estimate its volume and local spread Fusion of PET/CT and ultrasound to evaluate and biopsy lymph nodes.

Withdrawn6 enrollment criteria

Broad Spectrum HPV Vaccine Tolerability, Immunogenicity, and Efficacy Study (V502-003)

Cervical CancerCondylomata Acuminata

This study is to evaluate an investigational vaccine with the following objectives: (1) To demonstrate prevention of cervical, vulvar, and vaginal cancers and related precancers, external genital lesions, and persistent infection caused by the HPV types in the study vaccine, (2) To demonstrate that the vaccine is well-tolerated in women, (3) To evaluate vaccine immune responses in women. This is an early phase trial and some specific protocol information is proprietary and not publicly available at this time. (Full information is available to trial participants).

Withdrawn8 enrollment criteria

Impact of HPV Vaccination to Catch up in the Emergence of Lesions of the Cervix

HPV VaccinationPap Smear2 more

In France, the vaccination coverage observed for HPV vaccination is low for a full-scale regimen, and has been falling since 2010. A high rate of HPV vaccination coverage has a significant epidemiological impact with a reduction in cervical cancer mortality. There is less data on vaccinated catch-up patients. In 2017, these patients are 25 years of age or older and carry out screening smears. The aim of this study is to demonstrate whether HPV catch-up vaccination results in a decrease in the abnormal smear rate compared to the rate in unvaccinated patients. If so, these data will help mobilize doctors to vaccinate patients against HPV, even in catching-up.

Terminated6 enrollment criteria
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