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Active clinical trials for "Uterine Cervical Neoplasms"

Results 11-20 of 1335

Image Guided IMRT, Radiochemotherapy and MRI-based IGABT in Locally Advanced Cervical Cancer

Uterine Cervical Neoplasms

The research group on adaptive image-guided radiotherapy for locally advanced cervical carcinoma completed the protocol for the EMBRACE II study in October 2018. This study will be carried out in the next few years at the University Clinic for Radiotherapy at the Medical University of Vienna and other international partner institutes. EMBRACE II builds on the findings of the current EMBRACE study. These are already implemented in everyday clinical practice in order to further improve the accuracy of the entire therapy of cervical carcinomas, using state-of-the-art techniques of tele- and brachytherapy. The aim of the EMBRACE II study is to maintain and enhance the excellent local tumor control as well as the nodal and systemic control for all tumor stages while minimizing the adverse reaction rates for all affected organs (rectum, sigmoid, urinary bladder, and vagina) to increase the quality of life of patients with cervical carcinomas.

Recruiting19 enrollment criteria

The Efficacy of Salvage Surgery in Patients With Residual Tumor After Concurrent Chemoradiation...

Cervical Cancer

This is a single-center single-arm study. The main purpose of this study is to study the efficacy of surgical treatment for patients with locally advanced cervical cancer (FIGO IB3, IIA2-IVA) who still have residual tumor after concurrent radiotherapy and chemotherapy.

Recruiting18 enrollment criteria

Concurrent Radiochemotherapy Plus Anlotinib for Locally Advanced Cervical Cancer

Uterine Cervical NeoplasmsChemoradiotherapy1 more

To observe the efficacy and safety of hydrochloride anlotinib combined with concurrent radiochemotherapy for patients with FIGO stage IB3 and IIA2-IVA cervical cancer. Patient characteristics, image and genetic information of tumor, microbial sample of tumor microenvironment and biomarker in the blood sample will be collected and analysis by multi-omics and bioinformatic technology. Aim to provide a new treatment module for cervical cancer.

Recruiting44 enrollment criteria

Para-aortic Prophylactic Irradiation for Locally Advanced Cervical Cancer

Cervical Cancer

Para-aortic lymph node metastasis is a poor prognostic factor for locally advanced cervical cancer, but false negative diagnosis is easy to occur. The aim of this trial was to investigate whether para-aortic prophylactic radiotherapy improves disease-free survival in patients with positive pelvic lymph nodes below the common iliac artery.

Recruiting21 enrollment criteria

Study of Neoadjuvant Chemotherapy Versus Definite Concurrent Chemoradiotherapy for Locally Advanced...

Cervical CancerNeoadjuvant Chemotherapy

This phase III randomized prospective clinical study was conducted to compare the short-term and long-term outcomes of gemcitabine and cisplatin neoadjuvant chemotherapy versus definite cisplatin weekly concurrent chemoradiotherapy in patients with locally advanced bulk cervical cancer.

Recruiting13 enrollment criteria

Toripalimab Combined With Concurrent Chemoradiotherapy in Cervical Cancer

Cervical Cancer

To explore the efficacy and tolerance of adding toripalimab simultaneously and subsequently to concurrent platinum-based chemoradiotherapy in patients with locally advanced cervical cancer.

Recruiting20 enrollment criteria

A Study of BMS-986340 as Monotherapy and in Combination With Nivolumab or Docetaxel in Participants...

Cervical CancerGastric/Gastroesophageal Junction Adenocarcinoma10 more

The purpose of this study is to assess the safety, tolerability, and recommended dose(s) of BMS-986340 as monotherapy and in combination with nivolumab or docetaxel in participants with advanced solid tumors. This study is a first-in-human (FIH) study of BMS-986340 in participants with advanced solid tumors.

Recruiting18 enrollment criteria

Advanced or Recurrent Ovarian, Cervical, and Endometrial Cancer Treated With SHetA2

Ovarian CancerEndometrial Cancer1 more

The purpose of this research is to test the safety of the study drug (SHetA2) and see what effects (good and bad) this drug has on patients with recurrent cervical, ovarian, or endometrial cancer.

Recruiting37 enrollment criteria

Impact of Sonifilan on the Quality of Life in Patients With Cervical Cancer During Radiation or...

Cervical Cancer

The impact of sonifilan on the quality of life in patients with cervical cancer during radiation or chemoradiation therapy Primary endpoint : Quality of life Secondary endpoint : complications related to Sonifilan, treatment effect of Sonifilan

Recruiting9 enrollment criteria

Induction Chemotherapy Followed by Standard Therapy in Cervical Cancer With Aortic Lymph Node Spread...

Cervical Cancer TNM Staging Regional Lymph Nodes (N)

The main objective of this study is to determine whether neoadjuvant chemotherapy with Carboplatin and paclitaxel plus standard cisplatin-based chemoradiation with extended fields improves overall survival rates compared to standard therapy alone in women with cervical cancer with paraaortic lymph node involvement. Women in the experimental arm will receive neoadjuvant chemotherapy with carboplatin and paclitaxel every 21 days during 3 cycles followed by standard therapy with extended field external radiation therapy and concomitant chemotherapy. Women in the control arm will receive standard therapy with extended field external radiation therapy and concomitant chemotherapy. 310 patients will be recruited during 4.5 years, with 3 years of follow up period.

Recruiting16 enrollment criteria
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