the Treatment of Human Bone Marrow Mesenchymal Stem Cells in Ocular Corneal Burn
Chemical BurnsOcular chemical burn is one of the cause of vision loss in our country, and there are no satisfactory treatment. Human bone marrow mesenchymal stem cells (MSC) have the biological characteristics of self-renewal, immune regulation, multidirectional differentiation and tissue repair. Our preliminary research showed that in corneal alkali injury rats, the MSC can accelerated the cornea repair, inhibited angiogenesis. The aim of this study is to access the efficacy and safety of mesenchymal stem cell in the treatment of corneal burn in human.
Safety and Performance Study of the ARGOS-IO System in Patients Undergoing Boston Keratoprosthesis...
Graft vs Host DiseaseCongenital Aniridia3 moreThe ARGOS-IO pressure sensor is intended to be implanted in the human eye in combination with Boston Keratoprosthesis (BKPro) surgery and to remain in place indefinitely. It is intended to be used together with the hand-held Mesograph reading device to telemetrically measure the intraocular pressure (IOP) of patients with a BKPro. The purpose of this study is to evaluate the safety and performance of the ARGOS-IO system in patients undergoing concomitant implantation of a BKPro and an ARGOS-IO sensor over the 12 month period beginning at implantation.
Minor Salivary Gland Transplantation for Cicatrizing Conjunctivitis
Cicatrizing ConjunctivitisStevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum4 moreThis is a prospective study that aimed to observe the therapeutic effects of minor salivary gland transplantation for cicatrizing conjunctivitis patients.
The Improvement of Limbal Epithelial Culture Technique by Using Collagenase to Isolate Limbal Stem...
Alkaline Chemical Burn Of Cornea And Conjunctival SacAcid Chemical Burn Of Cornea And Conjunctival Sac1 moreUsing collagenase to isolate limbal stem cells and improve the technique of ex vivo expansion of limbal stem cells for the treatment of patients suffering from unilateral limbal stem cell insufficiency based on the concept of "limbal stem cells need special cell-cell contact and cell-extracellular matrix interaction to support their survival".
Subconjunctival Injection of Allogeneic Mesenchymal Stem Cells in Severe Ocular Chemical Burn
Bone Marrow DonorThe objective of this pre-clinical study is to demonstrate the robustness of Bone Marrow derived Mesenchymal Stem Cells (BM-MSC) production, to treat patients with severe eye burns. For bone marrow donors who agree to participate, a 10 ml BM sample will be collected apart the 1 liter BM dedicated to transplantation. A maximum of three donors of allogeneic BM-MSCs will be included. A ready-to-use BM-MSC suspension will be produced and stored for 10 years to accumulate data about stability of cryopreserved cells.
Clinical Trial on the Effect of Autologous Oral Mucosal Epithelial Sheet Transplantation
Limbal Stem Cell DeficiencyStevens-johnson Syndrome2 moreTo investigate the effect of ocular surface reconstruction and assess the safety in cultivated oral mucosal epithelial cell sheet transplantation (COMET) regarding patients with cicatricial change of ocular surface.
The Postoperative Head Position as a Predictor of the Surgical Outcome After DMEK
Fuchs Endothelial Corneal DystrophyPseudophakic Bullous Keratopathy2 moreThis study aims to investigate the influence of postoperative head position on clinical outcomes after DMEK via a wearable sensor.