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Active clinical trials for "Chondrosarcoma"

Results 61-70 of 78

IPI-926 Extension Protocol for Continuation of Treatment With IPI-926

Basal Cell CarcinomaChondrosarcoma

A treatment protocol that enables patients to have continued access to IPI-926.

Completed9 enrollment criteria

Stereotactic Body Radiotherapy for Head and Neck Tumors

Squamous Cell Carcinoma of the Head and NeckNasopharyngeal Carcinoma6 more

This study will evaluate the local control rates as well as acute and late toxicity rates of stereotactic body radiotherapy (SBRT) for the treatment of benign and malignant head and neck tumors.

Completed7 enrollment criteria

Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced,...

Adult AngiosarcomaAdult Desmoplastic Small Round Cell Tumor33 more

This phase I trial is studying the side effects and best dose of cixutumumab given together with doxorubicin hydrochloride and to see how well they work in treating patients with unresectable, locally advanced, or metastatic soft tissue sarcoma. Monoclonal antibodies, such as cixutumumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Drugs used in chemotherapy, such as doxorubicin hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving monoclonal antibody cixutumumab together with doxorubicin hydrochloride may kill more tumor cells.

Completed38 enrollment criteria

Linsitinib in Treating Patients With Gastrointestinal Stromal Tumors

Carney ComplexChondrosarcoma2 more

This phase II trial studies how well linsitinib works in treating younger and adult patients with gastrointestinal stromal tumors. Linsitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Completed39 enrollment criteria

Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients...

Adult Alveolar Soft-part SarcomaAdult Angiosarcoma27 more

This phase III trial is studying observation to see how well a risk based treatment strategy works in patients with soft tissue sarcoma. In the study, patients are assigned to receive surgery +/- radiotherapy +/- chemotherapy depending on their risk of recurrence. Sometimes, after surgery, the tumor may not need additional treatment until it progresses. In this case, observation may be sufficient. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as ifosfamide and doxorubicin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving chemotherapy and radiation therapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving these treatments after surgery may kill any tumor cells that remain after surgery.

Completed87 enrollment criteria

Imatinib in Patients With Desmoid Tumor and Chondrosarcoma

Advanced Desmoid TumorAdvanced Chondrosarcoma

The purpose of this study is to determine whether Imatinib Mesylate is active in diseases - such as Desmoid Tumor and Chondrosarcoma - expressing the receptor for the platelet-derived growth factor (PDGF) both in its isoform alpha and beta

Completed19 enrollment criteria

Lattice Stereotactic Body Radiation Therapy (Lattice SBRT) for Localized Unresectable or Metastatic...

Metastatic Chondrosarcoma

Unresectable (including metastatic) conventional chondrosarcoma requires high dose radiation for local control. Radiation Oncologists have traditionally used long radiation courses and concern for toxicity to surrounding organs at risk. Stereotactic body radiation therapy (SBRT) has the ability to deliver high doses of radiation in a manner that may improve clinical response but has size limitations. SBRT delivered with lattice radiotherapy (LRT) may safely dose escalate smaller portions of the tumor and also provide improved cancer control. This study is to evaluate the safety and initial efficacy of this treatment approach.

Withdrawn18 enrollment criteria

Understanding Engagement Trends in Chondrosarcoma Clinical Trials

Chondrosarcoma

Taking part in medical research usually favors a particular demographic group. But there is limited research available to explain what trial attributes affect the completion of these specific demographic groups. This study will admit a wide range of data on the clinical trial experience of chondrosarcoma patients to determine which factors prevail in limiting a patient's ability to join or finish a trial. It will also try to analyze data from the perspective of different demographic groups to check for recurring trends which might yield insights for the sake of future chondrosarcoma patients.

Not yet recruiting6 enrollment criteria

A Phase II of Nivolumab Plus Ipilimumab in Non-resectable Sarcoma and Endometrial Carcinoma

Soft Tissue SarcomaBone Sarcoma6 more

The purpose of this study is to determine whether nivolumab plus ipilimumab are effective and safe in the treatment of sarcoma and endometrial carcinoma patients with somatic deficient MMR as a selection tool.

Unknown status49 enrollment criteria

Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Low and Inter-mediate Grade...

Chondrosarcoma

The study is a prospective randomised clinical phase III trial. Proton therapy is the gold standard in the treatment of low and intermediate grad chondrosarcomas of the skull base. However, high-LET beams such as carbon ions theoretically offer biologic advantages by enhanced biologic effectiveness in slow-growing tumors. Up until now it was impossible to compare two different particle therapies, i.e. proton and carbon ion therapy directly with each other. The aim of this study is to find out, whether the biological advantages of carbon ion therapy mentioned above can also be clinically confirmed.

Unknown status10 enrollment criteria
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