Effect of Roflumilast on Pulmonary Function and Respiratory Symptoms in Patients With Chronic Obstructive...
Chronic Obstructive Pulmonary DiseaseCOPDThe aim of the study is to compare the effect of roflumilast and placebo on the lung function in patients with COPD.
Long-term Study of Safety and Efficacy of Roflumilast in Japanese Patients Older Than 40 Years With...
Chronic Obstructive Pulmonary Disease (COPD)The aim of this long-term study is to investigate the effect of roflumilast (APTA-2217) on the long-term safety in patients with chronic obstructive pulmonary disease (COPD) who completed the 24-week evaluation of study APTA-2217-06. Roflumilast will be administered orally once daily. The present study consists of a 28 weeks treatment period, and is an extension of the 24-week study APTA-2217-06 (registered study). The study will provide further long-term safety and efficacy data of roflumilast.
Endobronchial Valve for Emphysema Palliation Trial (VENT)
Chronic Obstructive Pulmonary DiseaseEmphysemaThe purpose of this study is to assess the safety and efficacy of the Emphasys Endobronchial Valve (EBV) and procedure (with pulmonary rehabilitation) compared to optimal medical management (with pulmonary rehabilitation) in patients with heterogeneous emphysema.
A Study of UK-369,003 on the Safety and Efficacy in Patients With COPD
Pulmonary DiseaseChronic ObstructiveA randomised, controlled study investigating the effect of UK-369,003 on exercise tolerance in patients with COPD
Lung Health Study II
Lung DiseasesLung Diseases2 moreTo determine if participants with chronic obstructive pulmonary disease, who were assigned to inhaled corticosteroids had a lower rate of decline in lung function and lower incidence of respiratory morbidity compared to participants assigned to placebo.
Trial of Inspiratory Muscle Rest and Exercise in Chronic Obstructive Lung Disease
Lung DiseasesLung Diseases2 moreTo test the effectiveness of ventilatory muscle rest (VMR) using home negative pressure ventilation (NPV) in improving exercise performance, alleviating dyspnea, and improving the quality of life in patients with severe chronic obstructive lung disease.
National Emphysema Treatment Trial (NETT)
EmphysemaLung Diseases3 moreTo evaluate the long term efficacy, morbidity and mortality associated with medical therapy with lung volume reduction surgery (LVRS) as compared to medical therapy alone and to define patient selection criteria. The trial, conducted in conjunction with a patient registry, is supported by the NHLBI, the Centers for Medicare and Medicaid Services (CMS), and the Agency for Healthcare Research and Quality (AHRQ).
Feasibility of Retinoic Acid Treatment in Emphysema (FORTE)
EmphysemaLung Diseases3 moreTo conduct feasibility studies on the use of retinoids in the treatment of emphysema. Specific objectives are to identify optimal patient populations, retinoids, doses, dosing schedules, routes of administration, and outcome measures preparatory to conducting a larger, controlled, clinical trial on the efficacy of retinoid therapy in the management of emphysema.
Assessment Of Different Scores In Predicting Outcome In AECOPD Patients In Emergency Department...
Chronic Obstructive Pulmonary Diseaseevaluate the value of different scores in predicting hospital mortality and Need for MV In patients presented to ED with AECOPD.
Exploring Clinical Predictors of COPD Exacerbation in a Community Cohort
COPD ExacerbationThe aim of our study is to assess the feasibility and benefits of the implementation of an interactive telemonitoring system for earlier detection of COPD exacerbations in a community cohort preventing further deterioration requiring hospital admissions.