A Study to Verify the Efficacy of YM177 (Celecoxib) in Postoperative Pain Patients
Post Operative PainAim of the study is to compare efficacy and safety of YM177 with placebo and etodolac in patients with postoperative pain.
An Efficacy and Safety Study to Compare Morphine 6-glucuronide (M6G) and Morphine in Patients Suffering...
Postoperative PainTo compare the incidence and severity of nausea in the study treatment groups, during the 18-hour period starting 6 hours after titration to pain relief; following confirmation of the assumption of non-inferiority between the two groups of pain relief over the 24 hour post-operative period. Pain relief and nausea will be determined by measuring the areas under the curves of pain intensity and nausea verbal rating scale scores.
Safety and Efficacy Study of KAI-1678 to Treat Subjects With Postoperative Pain
PainPostoperativeThe purpose of this study is to determine whether KAI-1678 is effective in the treatment of postoperative pain following total hip or total knee replacement.
Study of the Effect of the Drug Gabapentin on Postoperative Pain and Incidence of Postoperative...
ObesityMorbid2 moreThe purpose of this research study is to evaluate the drug gabapentin (Neurontin®) for its ability to reduce postoperative pain, the need for morphine-like pain medication, and the severity and frequency of postoperative nausea and vomiting in laparoscopic gastric bypass surgery patients.
Morphine COnsumption in Joint Replacement Patients, With and Without GaBapentin Treatment, a RandomIzed...
Postoperative PainTotal Hip ReplacementTotal hip arthroplasty is amongst the most painful procedures postoperatively, and pain management can be a challenge. Different measures have been introduced to manage severe postoperative pain in these patients. Previous studies have investigated gabapentin in acute postoperative pain and demonstrated reduced postoperative pain, postoperative morphine consumption, morphine related side effects, and postoperative pain scores. To date, this analgesia adjunct has yet to be investigated for total joint arthroplasty patients.
A Safety and Effectiveness Study of SABER®-Bupivacaine for Pain Following Shoulder Surgery
Postoperative PainThis is a research study testing SABER-Bupivacaine (an experimental pain-relieving medication). SABER-Bupivacaine is designed to continuously deliver bupivacaine, a common local anesthetic, for a few days in order to treat local post-surgical pain. The purpose of this study is to investigate safety (if there are any side effects) associated with the use of SABER-Bupivacaine and how well it works in reducing pain and opioid-related side effects following shoulder surgery.
Local Infiltration Analgesia Following Total Knee Arthroplasty
Postoperative PainThe primary aim of this study is to evaluate if intra- and postoperative administration of ropivacaine, ketorolac and epinephrine into the operating field would affect morphine consumption. Secondary end-points are hospital stay, pain intensity and side effects. In an attempt to assess the safety of this technique, knee function and patient satisfaction scores are assessed up to 3 months after surgery.
Phase II Study of Inhaled AeroLEF for Analgesia After ACL Knee Surgery
PainPost Operative PainTo evaluate the safety and efficacy of self-titration to effective analgesia with inhaled AeroLEF in patients with moderate/severe acute pain in the post-surgical setting.
Analgesic Effect of Paracetamol, Paracetamol + Codeine, Ibuprofen and Their Combination
PainPostoperativeThe purpose of this study is to determine whether the combination of paracetamol (acetaminophen) and other NSAIDs with or without weak opioids can give synergistic analgesic effect.
Local Infiltration Analgesia in Bilateral Knee Arthroplasty - Efficacy of Subcutaneous Wound Infiltration...
PainPostoperativeLocal infiltration analgesia is effective in total knee arthroplasty for postoperative pain management, but the efficacy of subcutaneous wound infiltration has not been evaluated. This study aims at evaluating the efficacy of subcutaneous wound infiltration in total knee arthroplasty in 16 patients undergoing bilateral knee arthroplasty.