A Study to Assess the Efficacy, Safety, and Tolerability of KPL-716 in Reducing Pruritus in Chronic...
Chronic Idiopathic UrticariaChronic Idiopathic Pruritus3 moreParticipants with diseases characterized by chronic pruritus experiencing moderate to severe pruritus will be enrolled in this pilot Phase 2 study. The diseases characterized by chronic pruritus investigated in this pilot study currently include chronic idiopathic urticaria (CIU), chronic idiopathic pruritus (CIP), lichen planus (LP), lichen simplex chronicus (LSC) and plaque psoriasis (PPs).
Effect of Omalizumab (Xolair) on Basophils in Patients With Chronic Idiopathic Urticaria
Chronic UrticariaThis study looks at changes in cell proteins in people with chronic hives treated with omalizumab.
Omalizumab in Chronic Spontaneous Urticaria Patients Non Responding to Initial Standard antihistaminE...
CHRONIC SPONTANEOUS URTICARIAEvaluate the proportion of patients with an urticaria control test [UCT] score of greater than or equal to 12 at Week 12.
Study of Mechanism of Action of Ligelizumab (QGE031) in Patients With Chronic Urticaria
Chronic Spontaneous UrticariaCholinergic Urticaria1 moreThe purpose of the study is to investigate the mechanism of action for ligelizumab (QGE031) treatment in patients with chronic urticaria. The study has two parts. The study population will consist of approximately 68 male and female healthy volunteers and patients. In Part 1, approximately 20 healthy volunteers and patients with chornic urticaria will be enrolled. In Part 2 approximately 48 patients with chronic urticaria (spontaneous chronic urticaria, cholinergic urticaria or cold urticaria). Part 1 consists of a screening period up 2 weeks and a visit with skin tests; there is no treatment taken in Part 1. Part 2 is randomized, subject, investigator and sponsor blinded. It consists of a screening period up to 4 weeks, a 16 week treatment period and a 12-week follow-up period after last treatment. A follow-up call at Week 32 will be performed via telephone.
A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of UCB8600 in Healthy...
Healthy Study ParticipantsChronic Spontaneous UrticariaThe purpose of the study is to assess safety, tolerability and pharmacokinetics (PK) of oral UCB8600.
A Study of MTPS9579A in Participants With Refractory Chronic Spontaneous Urticaria
Chronic Spontaneous UrticariaThis pilot and dose-ranging study will evaluate the efficacy, safety, and pharmacokinetics of MTPS9579A compared with placebo in participants with chronic spontaneous urticaria (CSU) refractory to antihistamines. This study comprises two parts. In Part 1, participants will be randomized to receive MTPS9579A or placebo. On the basis of positive results from Part 1, a dose-ranging Part 2 may be opened, where participants will be randomized to receive one of four MTPS9579A doses or placebo.
Etanercept for the Treatment of Chronic Urticaria
Chronic Idiopathic UrticariaThe purpose of this study is to evaluate the safety and efficacy of etanercept for patients with chronic idiopathic urticaria unresponsive to antihistamines.
Hydroxychloroquine Efficacy in Chronic Urticaria
Chronic UrticariaThis study is for those people with difficult to treat hives. We are investigating whether or not a different medication, hydroxychloroquine, works to treat a certain type of hives. Hydrochloroquine is currently approved by the Food and Drug Administration (FDA), for treating arthritis, therefore it is considered investigational in this study. Hypothesis: Hydroxychloroquine will prove to have an efficacious response in terms of Urticarial Symptoms, on patients with chronic urticaria.
Study to Evaluate the Efficacy, Safety, and Tolerability of Tirabrutinib in Participants With Antihistamine-Resistant...
Chronic Spontaneous UrticariaThe primary objective of this study is to evaluate the efficacy of tirabrutinib in reducing disease activity in participants with chronic spontaneous urticaria (CSU) with respect to change from baseline in urticaria activity score over 7 days (UAS7) at Week 8 when added to standard of care.
Response of Urticaria to Stress Intervention
Chronic UrticariaSeveral studies have shown a relationship between psychological stress and chronic urticaria (hives). The primary objective of this study is to evaluate the effect psychological stress intervention has on chronic urticaria.