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Active clinical trials for "Central Nervous System Diseases"

Results 31-40 of 156

Video-call Assisted Assessment of Acute Stroke in Addition to Stroke Severity Scales in a Prehospital...

Cerebrovascular DisordersBrain Diseases4 more

This study aims to investigate whether a live stream video between the on-call neurologist and the emergency medical services is feasible.

Recruiting5 enrollment criteria

Gadopiclenol Pharmacokinetics, Safety and Efficacy in Children < 2 Years of Age

Central Nervous System DiseasesPediatric Disorder1 more

This Phase II open-label, uncontrolled, multicenter trial is designed to investigate the pharmacokinetic (PK) profile of gadopiclenol in plasma, in pediatric patients aged up to 23 months inclusive (term neonates or preterm infants after the neonatal period), using a population PK approach. Primary objective is to evaluate the PK profile of gadopiclenol in plasma following single intravenous injection of 0.05 mmol/kg body weight (BW) in pediatric population aged up to 23 months (inclusive) scheduled for a contrast-enhanced MRI examination of any body region including central nervous system (CNS).

Recruiting8 enrollment criteria

Spinal Cord Stimulation for Restoration of Arm and Hand Function in People With Subcortical Stroke...

StrokeBrain Diseases3 more

The goal of this study is to verify whether electrical stimulation of the cervical spinal cord can activate muscles of the arm and hand in people with hemiplegia following stroke. Participants will undergo a surgical procedure to implant a system which provides epidural electrical stimulation (EES) of the cervical spinal cord. Researchers will quantify the ability of EES to recruit arm and hand muscles and produce distinct kinematic movements. The implant will be removed after less than 30 days. Results of this study will provide the foundation for future studies evaluating the efficacy of a minimally-invasive neuro-technology that can be used in clinical neurorehabilitation programs to restore upper limb motor function in people with subcortical strokes, thereby increasing independence and quality of life.

Enrolling by invitation11 enrollment criteria

Tolerance Study of Robotic-Assisted Virtual Reality Walking Rehabilitation for Non-Walking Stroke...

StrokeCentral Nervous System Diseases

The primary objective of this study is to evaluate the tolerance of the use of immersive virtual reality (VR) during robotic walking rehabilitation sessions by Gait Trainer (GT) in post-stroke patients. Secondary objectives aim to evaluate the motivation to participate in VR sessions compared to conventional sessions, the participants' sense of presence within the virtual environment, and the usability of the rehabilitation device created. Finally, we will report the actual walking time and number of steps stroke patients take in VR sessions and conventional sessions.

Not yet recruiting15 enrollment criteria

External Ventricular Drainage Post-Market Clinical Follow-up Registry

Cerebrospinal; Disorder

This post-market follow-up registry will capture clinical data specific to the safety and performance of the Integra External Ventricular Drainage Systems and Accessories.

Recruiting12 enrollment criteria

Transcutaneous Auricular Vagus Nerve Stimulation in Spinal Cord Injury

Spinal Cord InjuriesSpinal Cord Diseases5 more

This study is a single blinded prospective randomized monocentric study examining the effectiveness of transcutaneous auricular vagus nerve stimulation paired with rehabilitation and low frequency/antidromic stimulation of the pelvic somatic nerves. The investigator hypothesize that treatment using transcutaneous auricular vagus nerve stimulation will improve gait recovery in spinal cord injured participants already treating by rehabilitation and pelvic nerves neuromodulation.

Not yet recruiting17 enrollment criteria

NUMITOR Study: Nummular Headache Iberian Study on the Treatments and Outcomes in Real-World Setting...

Headache DisordersSecondary6 more

The NUMITOR study is an analytical observational study with an multicenter ambisective (retrospective and prospective) cohort design.

Recruiting9 enrollment criteria

Using Real-world Evidence to Analyze the Clinical Effects and Adverse Events of Butylphthalide in...

StrokeCerebral Infarction6 more

This is a retrospective, multi-center, real-world study. The researchers plan to include 10,000 cases of ischemic stroke patients using butylphthalide and 10,000 cases of ischemic stroke patients using Urinary Kallidinogenase. The main purpose is to analyze the effectiveness and safety of butylphthalide and establish the drug risk assessment management plan.

Recruiting2 enrollment criteria

The Personalized Parkinson Project de Novo Cohort

Parkinson DiseaseParkinsonian Disorders6 more

Currently, the Movement Disorders Society (MDS)-UPDRS scale remains the gold standard to document the outcomes in clinical trials for Parkinson's disease (PD). The MDS-UPDRS is far from infallible, as it is based on subjective scoring (using a rather crude ordinal score), while execution of the tests depends on clinical experience. Not surprisingly, the scale is subject to both significant intra- and inter-rater variability that are sufficiently large to mask an underlying true difference between an effective intervention and placebo. Digital biomarkers may be able to overcome the limitations of the MDS-UPDRS, as they continuously collects real-time data, during the patient's day to day activities. In this study the investigators are interested in developing algorithms to track progression of bradykinesia, gait impairment, postural sway, tremor, physical activity, sleep quality, and autonomic dysfunction (the latter being derived from e.g. skin conductance and changes in heart rate variability).

Recruiting9 enrollment criteria

Post-thrombectomy Intra-arterial Tenecteplase for Acute manaGement of Non-retrievable Thrombus and...

Ischemic StrokeAcute3 more

Multicentre, prospective, Multi-arm Multi-stage (MAMS) seamless phase 2b/3 interventional randomized placebo-controlled double-blinded parallel-assignment (2 arms with 1:1 randomization) efficacy and safety trial to test intra-arterial tenecteplase at the completion of thrombectomy versus best practice in participants with anterior circulation LVO receiving mechanical thrombectomy within 24 hours of symptoms onset.

Not yet recruiting20 enrollment criteria
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