Study of Safety and Potential Efficacy of SYN117 in Cocaine Dependent Volunteers
Cocaine DependenceThis study will assess the potential interaction and subjective effects between intravenous cocaine and SYN117 in non-treatment seeking cocaine dependant subjects
Multisite Controlled Trial of Cocaine Vaccine
Cocaine DependenceThe purpose of this study is to test the efficacy of a newly developed active vaccine against cocaine (TA-CD).
Serotonin, Impulsivity, and Cocaine Dependence Treatment
Cocaine DependenceThe purpose of this study is to compare the effects of citalopram versus placebo given in the context of contingency management for cocaine dependence.
Lamotrigine add-on Therapy for Bipolar Disorder and Cocaine Dependency
Bipolar DisorderCocaine DependenceThe purpose of this study is to determine if lamotrigine add-on therapy is associated with decreased cocaine craving and improvement in depressive symptom severity than placebo in a group of outpatients with bipolar disorder and cocaine dependence. Additionally, this study is examining whether lamotrigine add-on therapy is associated with decreased cocaine use and the improvement of manic symptom severity than placebo in a group of outpatients with bipolar disorder and cocaine dependence.
Baclofen for the Treatment of Cocaine Dependence - 1
Cocaine-Related DisordersThe purpose of this study is to assess the efficacy and safety of baclofen for the treatment of cocaine dependence.
Combination of Disulfiram Plus Naltrexone to Treat Both Cocaine- and Alcohol-dependent Individuals...
Alcohol-Related DisordersAlcoholism1 moreMany cocaine dependent individuals are also dependent on alcohol. Such individuals respond poorly to existing treatments and have received little research attention in the past. The purpose of this study is to determine whether the combination of naltrexone and disulfiram is useful in decreasing alcohol use and cravings in people diagnosed with both cocaine and alcohol dependence.
Treatment of Adult Attention Deficit Hyperactivity Disorder (ADHD) in Methadone Patients - 1
ADHDOpioid-Related Disorders1 moreThe purpose of this study is to treat Adult Attention Deficit Hyperactivity Disorder (ADHD) in methadone patients.
Integrated Treatment for Cocaine and Mood Disorders - 1
Cocaine DependenceDepressive Disorder1 moreThe purpose of this study is to test whether cognitive behavioral therapy and bupropion hydrochloride will help cocaine users, who are depressed, reduce or end their cocaine use and improve their mood.
Effectiveness of Modafinil and D-amphetamine in Treating Cocaine Dependent Individuals
Cocaine-Related DisordersCocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found. The purpose of this study is to examine the effects of d-amphetamine and modafinil, when given alone and in combination, in treating cocaine dependent individuals.
Behavioral Therapy Combined With Carbidopa/Levodopa for the Treatment of Cocaine Dependence
Cocaine AbuseCocaine-Related DisordersCocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found. The purpose of this study is to examine the effectiveness of levodopa and carbidopa in treating cocaine dependent individuals. In addition, this study will examine the effects of incentive rewards for treatment compliance.