Interaction Between Vanoxerine (GBR 12909) and Cocaine in Cocaine Dependent Individuals
Cocaine AbuseCocaine-Related DisordersCocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found. The purpose of this study is to determine the safety and effects of vanoxerine (GBR 12909) in treating cocaine dependent individuals.
Dopamine Reuptake Inhibitors of Cocaine Abuse - 1
Cocaine-Related DisordersThe purpose of this study is to evaluate dopamine reuptake inhibitors for cocaine abuse.
The Effect of Brief Potent Glutamatergic Modulation on Cocaine Dependence
Cocaine DependenceThis project will evaluate the effect of a single sub-anesthetic dose of ketamine on the time to first cocaine use and abstinence rates in 60 treatment-seeking cocaine-dependent individuals receiving mindfulness-based relapse prevention (MBRP) therapy, using a 5 week combined laboratory-inpatient and outpatient double-blind, randomized, controlled trial.
The Effects of GABA Enhancing Medications on Individuals Addicted to Cocaine - 3
Cocaine AbuseCocaine-Related DisordersGamma-aminobutyric acid (GABA) is a type of neurotransmitter, which is a chemical that transmits information within and from the brain to all parts of the body. By lowering the level of another neurotransmitter called dopamine, GABA may have the ability to diminish cocaine cravings in addicts. The purpose of this study is to gather information on the interaction between cocaine and selected GABA enhancing medications in individuals addicted to cocaine. This may lead to future clinical studies using GABA medications to treat cocaine addiction.
Pharmacotherapy Dosing Regimen in Cocaine and Opiate Dependent Individuals - 8
Cocaine AbuseOpiate DependenceThe purpose of this study is to examine two medications, modafinil and citalopram, in the treatment of cocaine dependent individuals who are maintained on methadone.
A Drug Treatment for Cocaine Users Who Are Also on Methadone Maintenance Treatment
Cocaine DependenceOpiate DependenceThe main goal of this study is to evaluate the safety and tolerability of 40 or 80 mg atomoxetine as a treatment for cocaine dependence. The Phase I studies summarized above support the safety of atomoxetine in combination with stimulants. As the next step, the investigators will evaluate the safety and tolerability of atomoxetine in a small clinical trial with cocaine users. If atomoxetine is found to be promising in this study and sufficiently powered, double-blind, placebo-controlled studies will be proposed.
Effects of Vigabatrin on Cocaine Self-Administration
Cocaine DependenceThe objective of this study is to determine if vigabatrin will decrease cocaine self-administration, cardiovascular effects, subjective effects and craving compared to placebo.
Predictive Values of Serotonergic Alterations for Outcome - 2
Cocaine-Related DisordersThe purpose of this study is to evaluate the predictive value of serotonergic alterations for outcome.
Phase I Functional Magnetic Resonance Imaging (fMRI) Pharmacodynamic Studies of Compounds for Opioid...
Cocaine-Related DisordersOpioid-Related DisordersThe purpose of Project 2 is to execute phase I functional magnetic resonance imaging (fMRI) studies to assess the effects of lorcaserin on brain target engagement (measured by fMRI brain activation and neural connectivity) in cocaine use disorder (CocUD) subjects and/or opioid use disorder.
Vigabatrin for Cocaine and Alcohol Dependence
AlcoholismCocaine DependenceThe purpose of this study is to evaluate the effectiveness of vigabatrin at reducing drug and alcohol use in individuals addicted to cocaine and alcohol. Vigabatrin is approved for the treatment of seizures. It has not been proven to be effective for the treatment of alcohol or cocaine dependence.