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Active clinical trials for "Brain Concussion"

Results 361-370 of 406

Change in Connectivity After mTBI Depending on Cognitive Reserve

Mild Traumatic Brain Injury

The purpose of this study is to investigate the role of cognitive reserve in change in connectivity in the brain (measured with functional magnetic resonance imaging, fMRI) and how this is related to symptoms and symptom resolution.

Completed9 enrollment criteria

Microstructural Changes in the Brain During Recovery After Mild Traumatic Brain Injury

Brain Concussion

This study examines the possible microstructural changes in the brain during recovery after mTBI using diffusion MRI.

Completed9 enrollment criteria

Objective Brain Function Assessment of mTBI/Concussion in College Athletes

Brain InjuriesTraumatic8 more

This study (Part 1) is designed to build a database including EEG, neurocognitive performance, clinical symptoms, history and other relevant data, which will be used to derive a multimodal EEG based algorithm for the identification of concussion and tracking of recovery. In addition, neuroimaging will be conducted at time of injury and following Return to Play (RTP).

Completed10 enrollment criteria

Assessment of Oculomotor, Vestibular and Reaction Time Response Following a Concussive Event

ConcussionMild4 more

This study is designed to evaluate the use of a collection of tests that measure the eye response, balance, oculomotor and reaction time tests to aid in the diagnosis of mTBI. The tests use highly precise measurement tools to assess various neurologic functions. (For example, high-speed cameras to record eye movement, high-end motors to precisely spin and move the subject, comprehensive analysis to stitch together the stimulus and the response.) Hypotheses: A battery of oculomotor, vestibular and reaction time tests will generate variables that when properly weighted and run through a given multi-variant analysis, will separate the subjects into one of two groups, mTBI or not-mTBI. A battery of neurologic assessment tests including reaction time, vestibular and oculomotor tests taxing a range of neurologic functions and executed using one or more of the I-Portal® family of devices, will generate responses that, when used by a trained physician, can aid in the diagnosis of an mTBI.

Completed25 enrollment criteria

Mild Traumatic Brain Injury Registry

Brain InjuryTraumatic

The purpose of the study is to gather information about patients with mild traumatic brain injury in order to develop guidelines for evaluation and treatment.

Completed21 enrollment criteria

Deployment Related Mild Traumatic Brain Injury (mTBI)

Mild Traumatic Brain Injury

The study will provide evidence on the long term outcomes of mTBI in service members returning from Afghanistan and Iraq. In addition, the study will provide evidence on mTBI incidence, and symptom patterns. Self-reported assessments at baseline and follow-ups will be combined with data on health care utilization and military job performance. The work, symptoms, and family interaction outcomes of returning soldiers screening positive for mTBI, combined mTBI and PTSD, and soldier controls will be compared at 3 months, 6 months, and at one year. The assessments over time will permit descriptions of symptom changes for these populations. It is likely the study will find similar findings to those of previous civilian studies - that concussive symptoms often resolve within months of injury. However, some soldier subsets may have chronic problems. Determining the incidence and outcomes of individuals with mTBI will assist medical providers in determining the types of follow-ups needed by returning service members and suggest the development of additional treatment interventions. These results may also inform treatment of civilian populations with mTBI. The three primary hypotheses are: Concussive symptoms at the time of return from serving in Afghanistan and Iraq and symptoms persisting 3 months, 6 months, and 12 months after return will be associated with extent of exposure to combat, injury mechanism, associated injuries (co-occuring injuries), PTSD and other psychiatric co-morbidities, and number of deployment-related mTBIs. Returning troops reporting concussive symptoms at the time of return from deployment will have more work related problems at each follow-up (including lower rates of return to duty, return to work, and poor quality of work). The mTBI screening tool will be sensitive and specific to mTBI when compared to the criterion measure, which is a structured interview conducted by clinicians blinded to the screening results.

Completed5 enrollment criteria

Australian UCSF Concussion in Athletes

ConcussionMild

Analysis of cardiac induced brain forces using cranial accelerometry has been shown to diagnose concussion in high school athletes. This trial expands on this observation by recording headpulse signals in a recently concussed athletes playing Australian rules football.

Completed10 enrollment criteria

Australian University of California San Francisco (UCSF) Concussion in Athletes (AUSSIE-2)

ConcussionMild

Analysis of cardiac induced brain forces using cranial accelerometry has been shown to diagnose concussion in high school athletes. This trial expands on this observation by recording headpulse signals in a recently concussed athletes playing Australian rules football.

Completed10 enrollment criteria

Multimodal Approach to Testing the Acute Effects of Mild Traumatic Brain Injury (mTBI)

ConcussionMild

The objective of the study is to determine the relative roles for various testing modalities in the diagnosis and prognosis of mild traumatic brain injury.

Completed11 enrollment criteria

Cerebral Microstructural Changes Following Mild Traumatic Brain Injury

Brain Concussion

This study examine the possible microstructural changes in the middle brain after mTBI using diffusion MRI

Completed9 enrollment criteria
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