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Active clinical trials for "Hyperaldosteronism"

Results 101-110 of 126

Tissue K+ in Primary Hyperaldosteronism

Primary HyperaldosteronismElectrolyte Disturbance

Recent human studies found tissue sodium storage in patients with hyperaldosteronism that could be detected non-invasively by 23Na-MRI. Tissue sodium accumulation could be mobilized upon treatment of hyperaldosteronism. Besides, former animal studies applying chemical electrolyte analysis indicate that this aldosterone induced sodium storage might be accompanied by intracellular potassium loss. Wether such an intracellular tissue Potassium loss occurs in vivo in patients with hyperaldosteronism and if this deficiency can be corrected by treatment is unclear. The investigators will employ 39K-MR Imaging at 7Tesla to further assess this hypothesis.

Unknown status7 enrollment criteria

Diagnostic Accuracy of Seated Saline Suppression Test for Primary Aldosteronism

Primary Aldosteronism

The present study was undertaken prospectively to compare the diagnostic significance of the seated saline suppression testing (SSST) with the captopril challenge testing (CCT) in hypertensive patients with suspected primary aldosteronism (PA) using the fludrocortisone suppression testing (FST) as the reference standard, and to investigate the optimal cutoff of SSST for differentiating PA from other forms of hypertension.

Completed12 enrollment criteria

Influence of Synacthen Infusion on the Results of Adrenal Venous Sampling in Patient With Primary...

Primary Aldosteronism

The project is aimed to determine the value of synacthen infusion on the results of adrenal venous sampling in patients examined for primary aldosteronism

Unknown status0 enrollment criteria

Predicting Reduction of Hypertension After Adrenalectomy for Primary Aldosteronism: a Multicenter...

Primary Aldosteronism Due to Aldosterone Producing AdenomaPrimary Aldosteronism1 more

Primary aldosteronism (PA) is the excessive endogenous production of the mineralocorticoid aldosterone. Although various rare forms of PA exist, the vast majority of cases are accounted by either an aldosterone-producing adenoma (APA) or bilateral adrenal hyperplasia. During the last decades the prevalence of PA has risen, predominantly due to better awareness of disease. Several studies estimated a prevalence of PA up to 17% in an unselected population of hypertensive patients. However, in a population with resistant hypertension the reported prevalence is even higher: 17-23%. This emphasizes the clinical impact of PA on morbidity and mortality due to high blood pressure. Since both hypertension and aldosteronism are independent risk factors for cardiovascular morbidity, the aim of treatment is curation or reduction of both. After an adrenalectomy for APA normalization of biochemical abnormalities is achieved in almost all cases. Nevertheless, curation of hypertension (systolic blood pressure <140 and diastolic blood pressure <90 mmHg) without the need of antihypertensive medication is accomplished in only 35-45% of the cases. In 2008 the Aldosteronoma Resolution Score (ARS) was developed. This score predicts the likelihood of complete resolution of the hypertension in patients with an aldosteronoma and has been validated by other investigator groups. Reduction of hypertension is also an important clinical outcome and is reported in 90-98% of the patients after surgery. In most studies reduction is defined as a certain decrease in blood pressure or antihypertensive medication. However, there is no consensus on the precise definition of reduction in these patients, which leads to incomparable results. The aim of the proposed study is to determine the proportion of patients with clinically relevant reduction of hypertension after adrenalectomy in a large cohort. Furthermore, the investigators aim to determine the characteristics predicting this clinically relevant reduction. Additionally, the investigators evaluate the predictive value of the Aldosteronoma Resolution Score for clinically relevant reduction and aim to develop a scoring system to help clinicians predict the likelihood of reduction of hypertension after adrenalectomy so it can be used for patient counseling.

Completed5 enrollment criteria

68Ga-Pentixafor PET/CT for the Subtyping Diagnosis of Primary Aldosteronism

Primary Aldosteronism

To evaluate the value of 68Ga-Pentixafor PET/CT in the diagnosis of primary aldosteronism subtype

Completed13 enrollment criteria

Prevalence of Primary Aldosteronism in Patients With Resistant Hypertension in China

HypertensionResistant to Conventional Therapy

Recent studies indicate that primary aldosteronism (PA) is a much more common cause of hypertension than had been demonstrated historically. In patients with resistant hypertension, the prevalence of PA from different clinics worldwide is about 10-20%. As has been no such data in China, the investigators are conducting a PA study in different province of China to evaluate the prevalence of PA in patients with resistant hypertension.

Completed9 enrollment criteria

Glucose Metabolism in Subjects With Aldosterone-Producing Adenomas

Primary Aldosteronism

This observational study tests the hypothesis that endogenous aldosterone impairs insulin secretion and insulin sensitivity in subjects with primary aldosteronism.

Completed38 enrollment criteria

Optimizing Diagnosis Of Primary Aldosteronism

Primary Aldosteronism

To optimize the confirmatory tests for primary aldosteronism.

Completed8 enrollment criteria

Prevalence of Primary Aldosteronism in Young Adults With Acute Stroke

Primary Aldosteronism

The guideline requires clinical works to screen for primary aldosteronism(PA) in young adults with family history of stroke at early onset. But the prevalence of PA in young adults with stroke onset before 45 years old had never been investigated. The study aimed to discover the prevalence as well as the clinical characteristics between patients with PA and those without PA during stroke attack. In order to fulfill this objective, investigators intended to conduct a cross-sectional study by taking screening and confirmatory tests among young adults who once admitted due to early onset of acute stroke.

Completed2 enrollment criteria

Comparison of Three Confirmatory Tests in the Diagnosis of Primary Aldosteronism

Primary Aldosteronism

To compare the diagnostic value of three confirmatory tests for primary aldosteronism.

Completed11 enrollment criteria
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