search

Active clinical trials for "Constipation"

Results 1-10 of 861

Study to Assess the Safety and Efficacy of Tenapanor for the Treatment of IBS-C

Irritable Bowel Syndrome With Constipation (IBS-C)

This is a randomized, double-blind, placebo-controlled study to assess the efficacy, safety and tolerability of tenapanor (25 mg and 50 mg) in pediatric patients (≥12 and <18 years old) with IBS-C when administered twice daily (BID) for 12 consecutive weeks.

Recruiting41 enrollment criteria

Home Transcutaneous Electrical Acustimulation (TEA)

Irritable Bowel Syndrome With Constipation

This study will assess the efficacy of two active treatments with TEA and a chemical neuromodulator (escitalopram aka Lexapro) versus a sham comparator or control group on abdominal pain.

Recruiting15 enrollment criteria

Effect of MiniGo as add-on to Oral Laxatives for Children With Constipation and Fecal Incontinence...

Functional ConstipationFecal Incontinence in Children

The goal of this clinical trial is to compare combination therapy with low volume trans anal irrigation (TAI) and oral laxatives to monotherapy with oral laxatives in children with functional constipation and fecal incontinence. The main questions it aims to answer are: Can more efficient treatment be achieved with aforementioned combination therapy? Does the well-being of the children change, when they are well treated for their symptoms? Is low-volume trans anal irrigation a tolerable treatment method for children? Participants will be randomized into 2 groups, where one group is treated with current standard treatment of PEG (oral laxatives), and the other group is treated with PEG + daily low volume TAI.

Recruiting15 enrollment criteria

Comparison of Two Intervention in Children With Functional Constipation

Constipation - FunctionalPediatric

The purpose of this study; to compare the effects of therapeutic motor control interventions and conventional treatment in children with functional constipation on symptoms, spinal posture and mobility and trunk muscles endurance.

Recruiting6 enrollment criteria

Transcutaneous Electrical Acupoint Stimulation (TEAS) for Chronic Constipation

Constipation - Functional

Transcutaneous electrical acupoint stimulation (TEAS) is an emerging technology for non-invasive neuromodulation that has broad potential implications and warrants further study. The investigators' clinical experience from the University of California, Los Angeles (UCLA) Center for East-West Medicine (CEWM) has also demonstrated that TEAS can be used as an effective self-care tool for patients with chronic illness who do not have the time or resources for frequent acupuncture treatments. Chronic constipation is the chosen area of study because of the large population with a substantial impairment in health-related quality of life and work productivity. The investigators have recently completed a randomized controlled trial (RCT) demonstrating the benefit of perineal self-acupressure on quality of life measurements in this population, which supports investigation into other acupuncture-based self-care interventions. Given these findings, the investigators hypothesize that home patient-administered TEAS can provide measurable improvements in both symptom severity and health related quality of life.

Recruiting22 enrollment criteria

Comparing Transanal Irrigation With Navina Smart vs. Standard Bowel Care in Patients With Multiple...

Neurogenic Bowel (Disorder)Fecal Constipation2 more

A randomized, superiority, controlled, interventional, prospective, multicentre, post-market study of TAI with Navina™ Smart versus Standard Bowel Care performed in a population of 92 subjects suffering from Multiple Sclerosis and confirmed Neurogenic Bowel Dysfunction. The study is expected to last for a total of 8 weeks per subject with two scheduled site visits.

Recruiting30 enrollment criteria

Safety and Preliminary Efficacy of BGP345A in Constipation Due to Opioid-based Medications

Opioid-Induced Constipation

The purpose of this study is to assess safety and preliminary efficacy of BGP345A in patients with constipation due to the use of opioid-based medications for the management of chronic non cancer pain.

Recruiting29 enrollment criteria

LAPEC for the Treatment of Severe Constipation

Cecostomy; ComplicationsConstipation

Effective treatment for constipation is a real clinical challenge especially in patients with severe symptoms. Dietary measures (bulking agents) and drugs (laxatives, stool softeners, suppositories and enemas etc.) have limited efficacy in severe cases. If conservative measures do not help, surgical therapies might be considered. Subsequently, antegrade enemas through percutaneous colonic catheter were introduced as a less invasive option for treating severe constipation. The cecostomy has been performed laparoscopically, percutaneously, and with the laparoscopic-assisted percutaneous endoscopic cecostomy (LAPEC) technique. This approach allows patients to deliver osmotic agents to the right colon.The procedure has been demonstrated to be safe and effective in young adults and pediatrics. To date, there are only few studies evaluating the safety and efficacy of the LAPEC procedure in adults and all have retrospective profile. The aim of this prospective study is to compare short and long-term efficacy and safety of LAPEC in patients with severe constipation. Symptoms of defecation will be the main outcome criteria.

Recruiting20 enrollment criteria

STOPS Trial: Total vs Subtotal Colectomy for Slow Transit Constipation

Slow Transit ConstipationSurgery

Total colectomy with ileorectal anastomosis is a traditional surgical option for slow transit constipation. Subtotal colectomy with caecorectal anastomosis is suggested to be a superior approach. However, the optimal surgical option for slow transit constipation (STC) is controversial.

Recruiting14 enrollment criteria

Clinical Study of Phage Therapy for Chronic Constipation Efficacy and Safety

Pib Specific PhageIntractable Constipation

The overall aim was to evaluate the efficacy of PiB-specific phages for the treatment of refractory constipation through clinical studies, primarily for the publication of scientific papers and to guide the development of phage therapies. The purpose of this study will be subdivided into three aspects from three aspects: target exposure level, target occupation, and functional effects after acting on the target, including:1) The distribution of PIB phage in the intestine of patients with refractory constipation;2) The killing effect of PIB phage on PIB bacteria in refractory constipation patients;And 3) therapeutic effect of PIB phage on patients with refractory constipation.

Recruiting2 enrollment criteria
12...87

Need Help? Contact our team!


We'll reach out to this number within 24 hrs