Active clinical trials for "Constipation"

Primary Objective: To evaluate the clinical efficacy of Naturetti (capsules) , considering the following criteria: Evacuation frequency during the treatment and follow-up period Consistency of stools during the treatment and follow-up period Global evaluation, regarding increase in frequency of evacuation and shape of stools. Secondary Objective: Number of days without evacuation Proportion of evacuation with pain Proportion of evacuation with strain Proportion of evacuation with incomplete sensation Proportion of blocked stools Proportion of manual maneuvers to facilitate defecation Proportion of subjects that adhere to the diet recommended Proportion of the patients who have to use rescue medication Level of constipation improvement, according to the patient evaluation To evaluate clinical tolerability of the study medication by the continuous use To evaluate the occurrence of adverse events related to the study drug To identify any drug interaction.

At least 60% of patients with constipation and dyssynergic defecation (anismus) and between 30-50% of patients with fecal incontinence exhibit impaired rectal sensation. The problem may be improved by biofeedback therapy. Traditionally, biofeedback therapy was performed by using a syringe-assisted technique. Although some respond to this method, many, particularly those with severe rectal hyposensitivity have proved to be refractory. Also, repeated inflation and deflation of a large volume of air, using a hand-held syringe is cumbersome and time consuming. Recently, in pilot observations, the investigators have seen that a barostat-assisted technique of biofeedback therapy was simpler and easier to perform and could possibly be more effective. The investigators' aims are: To perform a randomized controlled study that compares the syringe-assisted sensory conditioning (biofeedback therapy) technique with the barostat assisted sensory conditioning for improving the rectal sensation in patients with rectal hyposensitivity and bowel dysfunction. To investigate the impact of sensory conditioning on psychosocial issues and quality of life. To compare the cost-effectiveness of each therapeutic modality The specific hypotheses that will be tested are; When compared to those who receive syringe-assisted training, patients receiving barostat training will demonstrate: Lower sensory thresholds for rectal perception (first sensation, desire to defecate and urgency) Greater satisfaction with bowel function (VAS Score), stool frequency,consistency & straining. Better learning ability and greater ease of administering this training.

The study tested the hypothesis that soy polysaccharide fiber reduces clinical symptoms of chronic constipation.

The purpose of this study is to compare the effectiveness of massage based on the tensegrity rule and classical abdominal massage in persons with constipation.

The purpose of this study is to compare the efficacy and safety of prucalopride to placebo (an inactive substance that is compared with a drug to test whether the drug has a real effect in a clinical trial) in treatment of participants with chronic (very serious, life threatening) constipation (decreased number of or difficulty making bowel [the intestine] movements).

The purpose of this study is to compare bowel function/constipation that occurs during tapentadol treatment with that occuring during oxycodone treatment, as measured by the frequency of spontaneous bowel movements per week. The frequency of spontaneous bowel movements will be determined from a Bowel Function Patient Diary completed by the enrolled sujbects.

The primary objectives are to demonstrate that the treatment with OXN PR tablets is non-inferior to the treatment with OxyPR with regards to analgesic efficacy and locomotor function. to demonstrate that subjects with moderate to severe OA pain taking oxycodone/naloxone prolonged release tablets have improvement in symptoms of constipation compared to subjects taking oxycodone prolonged release tablets alone

Primary Objective: To evaluate the clinical efficacy of Naturetti (jelly sugar free) To test medication on subjects who suffer chronic functional constipation in 30 days use. Secondary Objectives: To demonstrate the clinical tolerability when daily used (repeated doses) of the components of the study drug. The components will be evaluated by the adverse events occurrence classified by possibly related, probably related and definitely related To demonstrate the clinical tolerability of the study medication by the continuous use during the second phase study To identify any adverse events related to the study drug To identify any drug interaction.

Multi-centre, double-blind, randomised, placebo-controlled, parallel group study.

The aim of the study is to show that new polyethylene glycol (PEG) solution without electrolytes is as effective in the treatment of constipation as PEG solution with electrolytes in the elderly institutionalized people. Also, the tolerability and the safety of the study drug will be examined.