Active clinical trials for "Conversion Disorder"

The purpose of this study is to investigate the clinical correlates of the effects of the COVID-19 pandemic on patients with Functional movement disorder (FMD) and Parkinson s Disease (PD). Primary objectives: To evaluate the change in neurological symptoms domain of the survey between pre and post-COVID 19 in FMD and PD patients. Secondary objectives: To evaluate the change in total score of the survey between pre and post COVID 19 in FMD and PD patients To evaluate the change in other symptom domains of the survey between pre and post COVID 19 in FMD and PD patients. Domains include: Mood/Energy, sleep, symptoms of abnormal movements related or unrelated to primary disease, physical health and exercise related change Exploratory objectives: To evaluate whether there is a modifying effect of disease group in the changes in total score or symptom domains To evaluate whether there is a relationship between disease severity and changes in total score or symptom domains To evaluate whether there is a correlation between changes across symptom domains To evaluate whether there is a correlation in raw score across symptom domains within each period Research Methods: Data will be solely collected through the use of online instruments via CiSTAR as a designed questionnaire. Questionnaire items A questionnaire aimed at determining the effects of the COVID 19 pandemic and subsequent isolation on functional state of patients with FMD and PD. The questionnaire items include: Items investigating Mood/Energy before and after COVID 19 out break Items investigating Sleep habits before and after COVID 19 out break Items investigating Neurological symptoms before and after COVID 19 out break Items investigating daily functioning before and after COVID 19 out break Items investigating Exercise habits before and after COVID 19 out break No questionnaire items will be actionable , which are items that would identify an imminent risk for participant safety requiring urgent and immediate medical or psychiatric

''This study aims to determine the relationship between functional movement screen (FMS), core stabilization and Y balance test. The study will include evaluations on 30 handball players and 30 sedentary individuals.'' Functional movement analysis is a biomechanical screening and evaluation system to identify limitations and asymmetries in 7 basic movements. This system reveals the kinetic chain interaction between mobility and stability required for basic performance. Unlike conventional assessment methods, FHA focuses on the efficiency and quality of the movement pattern, not on the number of repetitions or weight lifted. The main aim of the study was to reveal the relationship between functional movement screen and core endurance and Y balance test evaluations in handball players with objective data. Functional movement is the general name of the activities performed by individuals for function and the movements performed by individuals for function are examined with analysis methods. In an effective analysis, if people do not have appropriate stability and mobility, it is determined from which muscle-muscle group or joint the problem originates. Analyses play a role in determining which of the stabilization, mobilization and flexibility factors are problematic at which stage of the function. In addition, these methods are effective in preventing possible injuries while helping to improve balance, strength and power characteristics of individuals. Core stabilization problems cause significant posture and stabilization problems. These problems are reflected in functional movements. Core stabilization problems are thought to have negative effects on functional movement analysis scores. Active athletes with this problem will be more affected. This study also aimed to observe the differences between athletes and sedentary individuals. Studies defined the core as the part of the body in the musculoskeletal system consisting of the proximal lower extremities, abdominal structures, hips, pelvis and spine and stated that the core muscles are composed of the trunk and pelvis muscles. It is argued that trunk and pelvis stabilization is essential for all movements of the extremities. The transversus abdominis and multifidus work in cocontraction and control excessive anterior pelvic tilt, which is known to be associated with femoral internal rotation and adduction. The musculature of the core is referred to as the muscular corset over the trunk and spine that stabilizes the body with or without limb movement. The strength and stabilization of the core affects the fitness and physical fitness of athletes. Core exercises should be included in exercise programs planned to improve athletic performance. Core endurance tests have been defined to reveal the relationship between core stabilization and performance. Lateral bridge test and trunk flexor test are the preferred core endurance tests in this study. The Y balance test is a dynamic test that requires strength, flexibility, core control and proprioception in a single-legged stance. Functional movement analysis, core stabilization tests and Y balance test are assessment scales that provide objective data on stabilization, postural alignment and spinal alignment. It is envisaged that these three assessment parameters will support each other after the study. Functional movements are widely used during both daily and sports activities. Core stabilization and dynamic balance are the factors that determine the quality of functional movements. These movements become more important for athletes as they affect their sporting success. Athletes need a good evaluation to ensure and maintain success. Since handball is defined as a sport that requires a lot of effort, the risks increase and it becomes clear that the evaluation should be done with a holistic approach.Injuries in handball develop due to multifactors.Biomechanical, kinesthetic and functional losses in players should be determined to prevent injuries.Functional movement analysis, core stabilization, Y balance test will give us detailed information about posture, limb alignment and asymmetry, spinal smoothness, dynamic balance and will give us the chance to analyze whether there is a correlation between these tests.

The aim of this study is whether the proinflammatory cytokine levels in patients with conversion disorder is increased or not changed in the acute phase and subacute - chronic periode, compared with controls.

The schizophrenic disorders and pervasive developmental disorders are neurodevelopmental disorders distinct origin who share common challenges to engage and maintain social relationships and mutual disturbances of affective contact. An important issue of research is to determine the cognitive and brain mechanisms underlying social disability in these two pathologies. Several lines of social cognition have been systematically explored: the perception of emotions, the ability to attribute intentionality and mental states to others (theory of mind), the understanding of social situations in different contexts. We made the observation today that research findings clearly in the field of autism and schizophrenic disorders that converge on common patterns neurocognitive abnormalities. Consequently, many programs support published today use the same therapeutic targets and the same tools in both pathologies. This raises two questions of science: (1) whether the disorders of social cognition reported in the field of autism and schizophrenia are "specific deficit" and not "specific condition", that is to say they are inherent social disadvantage whatever condition or (2) if these disorders of social cognition is a pattern common to autism and schizophrenia but are the result of specific neurocognitive mechanisms and different in each these pathologies. Systematic exploration of these issues is a current issue for understanding the pathophysiological borders between the two neurodevelopmental disorders but also to better define the potential targets of therapeutic strategies, psycho-educational and remediation of disorders of social cognition in autism and schizophrenia. Main objective: To compare clinical cognitive profiles in adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition: perception of emotions, attribution of intentions to others (theory of mind) and style attribution. We shall constitute three population groups of patients, a group of patients meeting the diagnosis of schizophrenia, a group of patients with autism and a control group (healthy subjects).

Functional disorders, also called psychogenic or psychosomatic are very common, disabling and their costs to society are immense. Functional movement disorders are abnormal, involuntary movements, that are illogical in terms of classic neurology. Intriguingly, they typically manifest when patients pay attention to them and disappear with distraction. The investigators aim to further the understanding of the pathophysiological mechanisms underlying functional neurological disorders in order to improve treatment. In particular they aim to understand the effect of attention on movement in general, on functional neurological mechanisms and on the sense of agency (of subjective control) over a movement. Patients with a functional neurological disorder, patients with an organic neurological disorder and healthy participants will perform simple tasks, such as reaching to a target, while additional tasks will manipulate their attention. The effects of these attentional manipulations will be analysed on several levels: movement performance, analysed by the kinematics and electromyography (EMG),and psychophysical measures, such as the sense of agency. If the hypothesis turns out to be true, then changing the attentional focus could be used as a treatment in functional neurological disorders.

Monocentric retrospective observational cohort study, using a consecutive series of patients hospitalized for FND from 2012 to 2015 in the neurology department A of the Grenoble Alpes University Hospital. During the discharge staff, an estimation of different prognostic factors had been performed in a consensual way by the medical team for all subjects. It is possible to calculate a score (POS) retrospectively from the data collected during the staff. The following items were evaluated on a Likert scale from 1 to 5: quality of adherence to the diagnosis, presence of a current medical treatment, presence of a similar history, duration of evolution of the disorders presented, ability to verbalize, presence of a social adaptation to the disorders, access to psychiatric care. The aim of the study will be to study the properties of the calculated score according to the evolution of the patients. The investigators will retrospectively collect information from the medical records. In addition, the evolution of the disorder since the initial hospitalization will be analyzed via a self-evaluation by the subjects and the study of the current medical records. The investigators will also collect information on the quality of life of the patients in the cohort and their perception of the disease at present. Using a Clinical Global Impression (CGI-I) scale on FNDstatus, subjects will be classified into two groups by the two principal investigators (Dr. Vercueil, M. Bratanov): the first with a favorable evolution (disappearance of symptoms at the last follow-up, low health care consumption, favorable self-assessment of health status, persistence of symptoms at a low level of disability, satisfactory social and professional integration), and the second with an unfavorable evolution (persistence of symptoms at a disabling level, high health care consumption, unfavorable self-assessment of health status, lack of social and professional integration, multiple medical consultations). The prognostic properties of the POS score will be then studied in order to establish an ROC curve that will allow to classify patients in the two groups.

The main goal of the proposed project is to assess treatment-induced changes of electrophysiological and psychophysiological correlates of the capacity to regulate emotion, executive functions, and clinical measures in individuals with complex posttraumatic stress disorder and dissociative disorders in a naturalistic inpatient setting.

Functional Neurological Disorder (FND/ Conversion Disorder) is a highly prevalent and disabling neuropsychiatric condition. Motor FND symptoms include Functional Movement Disorders (FMD) and Functional Weakness and Psychogenic Nonepileptic Seizures (PNES).Though patients with FND present with a wide variety of symptoms, FMD, PNES, and functional weakness may be viewed as overlapping conditions lying along a phenotypic spectrum for a single disorder. Patients with FND frequently present with psychiatric symptoms, including depression, anxiety, Borderline Personality Disorder, and Post-Traumatic Stress Disorder, alongside their physical symptoms. To treat these symptoms, patients with FND are frequently enrolled in physical therapy and cognitive behavioral therapy, which are considered usual care for FND at our center. Developing a further understanding of treatment outcome, including biomarkers of clinical improvement and psychometric factors associated with treatment response, could inform future interventions and better tailor treatments to patients with specific FND symptom profiles. We hypothesize that treatment response will be associated with structural and functional alterations in salience network regions and that more adaptive neuropsychiatric profiles at baseline will predict a positive treatment outcome.

The research focuses on Cauda Equina Syndrome (CES) which describes damage to the nerves in the lower back which supply bladder, bowels, sexual function and the legs usually from slipped discs in the spine. CES is as common as multiple sclerosis and is diagnosed using an MRI scan of the spine, 'scan positive' CES. However, about 50% of people presenting with the symptoms of CES have MRI scans which do not explain their symptoms, 'scan negative' patients. The BLB study will be the first large clinical study comparing patients with 'scan positive' and 'scan negative' CES. All patients admitted to the Western General Hospital, Edinburgh with possible CES will be invited to participate. The study consists of detailed history taking, examination and a questionnaire following up patient's symptoms at three months. The study aims to see what differences exist between the 'scan positive' and 'scan negative' groups, help doctors understand more about the outcomes of both groups and discover the number of patients with 'scan negative' CES who have functional disorders (previously called medically unexplained or conversion disorders) or undiagnosed neurological disorders.

THe aim of this study is to determine the frequency of dissociative tendencies in the obese population treated at the CELIOBE (Liberal Center for Obesity Support) at Hôpital Privé La Louvière among patients consulting for the first time and looking for a medical or surgical course. The DES scale of Carlson and Putman will be used.