![Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland](https://trials-media.s3.amazonaws.com/orgs/center-for-primary-care-and-public-health-unisante-university-of-lausanne-switzerland.jpeg)
PCR and Rapid Diagnostic Test on Saliva and Nasopharyngeal Swabs for the Detection of SARS-CoV-2...
COVID-19SARS-CoV-2Recent literature shows that the sensitivity of the PCR tests for the detection of SARS-CoV-2 using saliva samples is close to that using nasopharyngeal swabs. This type of sampling represents a practical advantage since it can be performed by the patient herself/himself and would thus allow to speed up the collection process. It is also less painful and could prevent the rare lesions to the nasal mucosa that can occur when using nasopharyngeal swabs. Rapid Diagnostic Tests for the detection of SARS-CoV-2 antigens have been developed using nasophayngeal swabs and have shown very high sensitivity against PCR, ranging from 93% to 98% when based on laboratory validation, 80% when based on clinical validation.This method offers the considerable advantage to inform the patient of the test result on site, and allow the provision of appropriate recommendations on the spot of testing. The studies performed so far have been conducted using nasopharyngeal samples only. There are no data with saliva yet. It is expected that the RDT would also work on the saliva. Even if slightly less sensitive due to the fact that it detects antigens and not multiplied RNA as PCR does, RDT on saliva could better serve the public health goal to test widely and quickly and have ultimately more COVID cases detected and isolated, and hence reduced transmission. To investigate the case detection rates of both PCR on saliva and nasopharynx and RDT on nasopharynx and saliva, the patient will be taken four samples, two swabs on saliva, one for RDT and one for PCR, and two swabs on nasopharynx, one for RDT and one for PCR. Patients who have at least one of the common symptoms and who consent to such a procedure will be recruited to compare the four results. The primary objective is to compare the case detection rates for SARS-CoV-2 of the four testing methods (two sampling types and two test types).
![Tepecik Training and Research Hospital](https://trials-media.s3.amazonaws.com/orgs/tepecik-training-and-research-hospital.jpeg)
Endoscopic Procedures of Children in the Normalization Process of Covid-19 Pandemic
Covid19Endoscopic methods are frequently used in the diagnosis of gastrointestinal system pathologies in children.
![Inger Lise Gade](https://trials-media.s3.amazonaws.com/orgs/inger-lise-gade.jpeg)
Non-invasive Prognostication of COVID-19 Patients by Use of Biomarkers in Exhaled Breath Condensate...
Covid19Corona Virus InfectionThe main objective of this study is to assess if analysis of exhaled breath condensate (EBC) can provide useful prognostic markers for admission to the intensive care unit (ICU) due to acute respiratory insufficiency among patients with Coronavirus disease 2019 (COVID-19). Additionally, to give a characterization of the lung damage caused by COVID-19 by analysis of daily blood samples. The hypothesis is that the protein content of the EBC from COVID-19 patients who require admission to the ICU differs from the EBC from COVID-19 patients with uncomplicated hospitalization, potentially providing diagnostic markers of COVID-19 related pulmonary damage.
![Federico II University](https://trials-media.s3.amazonaws.com/orgs/federico-ii-university.jpeg)
OCTA Study: Retinal Vascular Changes in Patients With SARS-CoV-2 Infection
Covid19This study evaluates the retinal vascular features using optical coherence tomography angiography in patients that have been affected by COVID-19.
![Oslo University Hospital](https://trials-media.s3.amazonaws.com/orgs/oslo-university-hospital.jpeg)
Survival Rates and Longterm Outcomes After COVID-19
Covid19Acute Respiratory Failure3 moreThe study 'Survival rates and long-term outcomes for patients with COVID-19 admitted to Norwegian ICUs' is a national observational study, including patients admitted to a Norwegian ICU between March 2020 and March 2021. The study will describe survival rates, clinical characteristics and health challenges experienced by survivors the first year after ICU admission caused by COVID-19 disease.
![University of Cagliari](https://trials-media.s3.amazonaws.com/orgs/university-of-cagliari.jpeg)
The Impact of COVID-19 Pandemic on Thyroid Surgery in Italy: Results From a Nation-wide Multicentric...
Thyroid DiseaseItaly has been on the frontline of the COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, the need to focus resources to deal with the pandemic led to a disruption of routine surgical care, as well as activity for oncologic and chronic disease. The aim of this study was to evaluate the impact of COVID-19 pandemic on surgical activity of the Italian Units of Endocrine Surgery belonging to the SIUEC (Italian Society of Endocrine Surgery), the most important national scientific society of endocrine surgery.The aim of this study was to evaluate the impact of COVID-19 pandemic on surgical activity of the Italian Units of Endocrine Surgery belonging to the SIUEC (Italian Society of Endocrine Surgery), the most important national scientific society of endocrine surgery.
![Adaptive Phage Therapeutics, Inc.](https://trials-media.s3.amazonaws.com/orgs/adaptive-phage-therapeutics-inc.jpeg)
Personalized Phage Treatment in Covid-19 Patients With Bacterial Co-Infections Microbials for Pneumonia...
Covid19Bacteremia4 morePhage Treatment in Covid-19 Patients with Bacterial Co-Infections
![Evidation Health](https://trials-media.s3.amazonaws.com/orgs/evidation-health.jpeg)
A Virtual Prospective Study Exploring Activity Trackers and COVID-19 Infections
Covid19SARS-CoV InfectionProspective, observational, exploratory study exploring the relationship between passively-collected data from wearable activity devices and SARS-CoV-2 infection
![NYU Langone Health](https://trials-media.s3.amazonaws.com/orgs/nyu-langone-health.jpeg)
Blood Volume Assessment in COVID-19 and Bacterial Sepsis
Covid19Acute Respiratory Distress Syndrome2 moreIn patients with SARS-CoV-2 or bacterial infection admitted to the intensive care unit (ICU), the state of the intravascular volume, the characteristics of the blood volume components, and the development of a vascular leak is currently unknown. The relationship of these parameters with parameters of cardiac performance, lung edema and sublingual microcirculatory perfusion parameters have never been studied.
![Kahramanmaras Sutcu Imam University](https://trials-media.s3.amazonaws.com/orgs/kahramanmaras-sutcu-imam-university.jpeg)
Clinical Outcomes of Newborns Born to Pregnant Women With and Without COVID-19
Covid19Vertical Transmission of Infectious Disease2 moreA case-control trial was conducted to test the early postpartum period clinical outcomes of newborns born to pregnant women with and without COVID-19.