
Early Tracheostomy in Ventilated Stroke Patients
Ischemic StrokeIntracerebral Hemorrhage1 morePatients with severe ischemic and hemorrhagic strokes, who require mechanical ventilation, have a particularly bad prognosis. If they require long-term ventilation, their orotracheal tube needs to be, like in any other intensive care patient, replaced by a shorter tracheal tube below the larynx. This so called tracheostomy might be associated with advantages such as less demand of narcotics and pain killers, less lesions in mouth and larynx, better mouth hygiene, safer airway, more patient comfort and earlier mobilisation. The best timepoint for tracheostomy in stroke, however, is not known. This study investigates the potential benefits of early tracheostomy in ventilated critically ill patients with ischemic or hemorrhagic stroke.

Functional Magnetic Resonance Imaging (fMRI) and Robot-Assisted Practice of Activities of Daily...
HemiparesisIschemic Stroke1 moreThe investigators will study motor recovery after robot-assisted therapy after stroke. A small clinical trial will be conducted to quantify the central nervous system changes associated with robotic or standard training, and identify trends across high and low responders in terms of patterns of change in cortical activity and type of white matter connectivity.The investigators hypothesize that robot training will lead to larger improvements as compared to standard occupational therapy. The investigators hypothesize that high responders to the robot training will have reduced compensatory activation in the bilateral area and will connectivity in the motor tracts.

AXIS 2: AX200 for the Treatment of Ischemic Stroke
Acute Ischemic StrokeThe purpose of this study is to assess the efficacy of AX200 (filgrastim) in the treatment of acute ischemic stroke and to assess the safety and tolerability of AX200.

Granulocyte-colony Stimulating Factor for Stem Cells Therapy for Acute Ischemic Stroke
Ischemic StrokeThe aim of the study is to investigate treatment with Leukostim (Filgrastim; granulocyte-colony stimulating factor; G-CSF) for acute ischemic stroke.

Dose Escalation of Desmoteplase in Acute Ischemic Stroke (DEDAS)
StrokeThe purpose of this study was to explore trends in safety and efficacy, and to find the optimal dose for the subsequent phase III trial. The decision to initiate the phase III trial will depend on both safety (incidence of symptomatic intracranial hemorrhage) and efficacy (reperfusion measured by MRI and correlating with clinical outcome) profiles. The safety (incidence of symptomatic intracranial haemorrhage) and efficacy (reperfusion measured by MRI and correlating with clinical outcome) profiles gained from this study were the basis of planning the phase III.

Safety/Feasibility of Autologous Mononuclear Bone Marrow Cells in Stroke Patients
Ischemic StrokeThe purpose of this research study is to find out if bone marrow treatment (bone marrow aspiration and infusion of stem cells) can be safely used in adults who have recently (within 24-72 hours)suffered an acute ischemic stroke.

Multi MERCI (Mechanical Embolus Removal in Cerebral Ischemia [MERCI™])
Ischemic StrokeThe primary objectives of the Multi MERCI trial were: to evaluate the addition of the Merci L5 Retriever additionally permit use of the Merci Retrieval System in the setting of persistent clot following IV t-PA treatment (use in the 0-8 hour window for patients ineligible for IV t-PA was also permitted)

AISTCM-Outcome Measurement of Acute Ischemic Stroke With Traditional Chinese Medicine
Cerebral InfarctionThe purpose of this study is to determine whether Traditional Chinese Medicine (TCM) is able to improve the outcome of acute ischemic stroke and to observe its safety.

Safety and Efficacy Study in Acute Ischaemic Stroke
StrokeA Phase II study to evaluate the safety and efficacy of five dose levels of study drug in acute ischaemic stroke

Randomized, Controlled Trial of Extended-Release Niacin (Niaspan®) to Augment Subacute Ischemic...
Ischemic StrokeThe purpose of this study is to determine the safety, tolerability, and to explore the possible benefit of extended-release niacin (Niaspan®) in attempting to improve the recovery of patients after ischemic stroke.