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Active clinical trials for "Deafness"

Results 1-10 of 613

A Feasibility Study Evaluating the Performance of Focused Multipolar Stimulation and Sound Coding...

Hearing ImpairmentSensorineural

The purpose of this early feasibility study is to explore several facets of hearing performance that may show improvements for alternative modes of stimulation compared to Monopolar (MP stimulation) in cochlear implant recipients. This study will iteratively evaluate different parameter sets that intend to maximize hearing performance benefits within technical requirements. This study is exploratory in nature and will achieve its objectives through ongoing review and adjustment of device parameters and fitting

Recruiting26 enrollment criteria

Expanded Indications in the Pediatric BONEBRIDGE Population

Hearing LossConductive2 more

This study will assess safety and efficacy of the MED-EL BONEBRIDGE Bone Conduction Implant in children under 12 years old with conductive or mixed hearing loss.

Recruiting15 enrollment criteria

Neural Prediction to Enhance Language

Bilateral Sensorineural Hearing LossSpeech and Language Development Delay Due to Hearing Loss1 more

The language outcome of children receiving cochlear implantation to address bilateral sensorineural hearing loss is more variable than that of typical hearing children. The research is focused upon development of neural predictive models based upon brain imaging to forecast language after cochlear implantation on the individual child level. The long-term goal is improving children's language by using predictive models to enable a custom "predict to prescribe" approach to intervene with more effective behavioral therapy for children at risk to develop poorer language. The investigators previously developed models for short term language outcome of English-learning implanted children. The aims of this study are to 1. Develop models able to predict long term outcome for English- learning and Spanish-learning children; and 2. To evaluate whether English-learning children predicted to achieve lower language based on the investigators' previously constructed models can demonstrate significant gains from Parent Implemented Communication Treatment (PICT). PICT is an intensive parent education program about strategies to improve children's communication.

Recruiting22 enrollment criteria

Gene Therapy Trial for Otoferlin Gene-mediated Hearing Loss

Sensorineural Hearing LossBilateral

Part A of this trial will evaluate the safety and tolerability of a single unilateral administration of one of two dose levels of AAVAnc80-hOTOF and will evaluate the Akouos delivery device to safely achieve the intended product performance.

Recruiting8 enrollment criteria

Small Sample,Unicentric,Randomized, Controlled Clinical Study of Coenzyme I for Injection in the...

Sudden Sensorineural Hearing Loss

Sudden sensorineural hearing loss is one of the most common emergencies in otorhinolaryngology, and its incidence is increasing year by year and tends to be younger. At present, the pathogenesis of sudden deafness is not clear and the individual treatment effects vary significantly. In order to break through this specific treatment bottleneck, this project pioneered the clinical application of the co-regulator nicotinamide adenine dinucleotide (NAD+) in the treatment of sudden deafness. Therefore, this project intends to use pure tone audiometry, speech audiometry, tinnitus disability scale THI, tinnitus subjective visual analog score method VAS, ear fullness subjective visual analog score method VAS for data analysis, and explore the safety of coenzyme I for injection on sudden deafness and efficacy assessment.

Recruiting11 enrollment criteria

Single-Sided Deafness in the Medicare Population

Hearing LossUnilateral

The purpose of this study is to evaluate the safety and effectiveness of cochlear implantation in adults 65 years of age and older.

Recruiting14 enrollment criteria

The Effect of PAP on ISSHL Comorbided With OSA

Sudden Hearing LossObstructive Sleep Apnea

This clinical randomized controlled study is to explore the effect of positive airway pressure(PAP) on patients in Beijing Tsinghua Changgung Hospital diagnosed with both idiopathic sudden sensorineural hearing loss comorbided(ISSHL) and obstructive sleep apnea(OSA) between Dec. 2019 to Dec. 2029.

Recruiting10 enrollment criteria

Technology-assisted Language Intervention (TALI)

Hearing LossBilateral1 more

This study is testing the effectiveness of augmentative and alternative communication technology among deaf or hard of hearing children for improving language development. Children will be randomized to receive either the technology intervention or treatment as usual

Recruiting9 enrollment criteria

Efficacy and Safety of Liuwei Dihuang Pill Versus Placebo in Presbycusis With Shen (Kidney)-Yin...

PresbycusisAge-related Hearing Loss1 more

The objective of this study is to examine the effects and safety of Liuwei Dihuang pill and placebo in presbycusis with Shen (kidney)-yin deficiency.

Recruiting15 enrollment criteria

Development and Assessment of a Spanish-Language Hearing Loss Toolkit for Self-Management

Hearing Loss

The objective of this application is to develop and evaluate Spanish-language hearing education materials for adults. Our hypothesis is that participants will demonstrate better understanding of their hearing loss and associated difficulties, and will be better able to identify options for self-management following delivery of culturally and linguistically appropriate patient education materials.

Recruiting3 enrollment criteria
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