Multicenter Unsustained Tachycardia Trial (MUSTT)
ArrhythmiaCardiovascular Diseases8 moreTo determine the value of electrophysiologic (EP)-guided antiarrhythmic therapy in coronary heart disease patients at increased risk for sudden death. The study included a controlled clinical trial and a registry.
Coenzyme Q10 in Post-Cardiac Arrest Cerebral Resuscitation
Cardiac ArrestSudden Cardiac ArrestSpecific Aim #1: To determine if levels of CoQ10 are low post-cardiac arrest (CA). We will perform a prospective trial with the primary endpoint of describing the prevalence of low serum CoQ10 levels. Specific Aim #2: To determine if CoQ10 levels in post-CA patients can be increased with the administration of exogenous CoQ10.. We will perform a randomized control trial (RCT) of post-CA patients with the secondary endpoint of comparing CoQ10 levels among those randomized to CoQ10 supplementation vs placebo.
Antiarrhythmics Versus Implantable Defibrillators (AVID)
ArrhythmiaCardiovascular Diseases7 moreTo evaluate if use of an implantable cardiac defibrillator (ICD) results in reduction in total mortality, when compared with conventional pharmacological therapy, in patients resuscitated from sudden cardiac death who are otherwise at very high risk of mortality from arrhythmic causes.
Coronary Artery Bypass Graft (CABG) Patch Trial
ArrhythmiaCardiovascular Diseases8 moreTo test the hypothesis that implantable cardioverter defibrillator (ICD) therapy will improve survival in coronary heart disease patients at high risk of death, especially arrhythmic death.
ASSURE WCD Clinical Evaluation - Conversion Efficacy Study
DeathSudden1 moreA multicenter single arm open label evaluation of the ASSURE Wearable Cardioverter Defibrillator (WCD) defibrillation waveform in adult cardiac patients
Optimization of VNS in Epileptic Patients to Induce Cardioprotection
EpilepsySudden Cardiac DeathThis study is a non-randomized, prospective study in patients with a diagnosis of epilepsy and previously implanted FDA approved Vagus Nerve Stimulation (VNS) devices. The goal of this clinical investigation is to evaluate the effects of adjusting vagus nerve stimulation parameters to engage cardioprotective effects.
Post-market Surveillance of Micorport CRM Cardiac Implantable Electronic Devices
Cardiac Rhythm DisorderHeart Failure1 moreThe primary objective of the study is to assess the chronic safety of MicroPort CRM market-released systems.
REASSURE AV Registry
Sudden Cardiac DeathBradycardiaLong term follow-up to monitor safety for patients implanted with a B301 ASSURE device.
Effect of Ranolazine on Arrhythmias and Microvolt T- Wave Alternans (MVTWA) Patients With LV Dysfunction...
Sudden Cardiac DeathVentricular ArrythmiasThe purpose this investigation is to more thoroughly investigate the effects of ranolazine on arrhythmias and microvolt t-wave alternans in patients who have an automatic implantable cardioverter defibrillator (AICD) implanted either prophylactically to prevent sudden cardiac death, as well as in patients who may have had a clinically significant arrhythmic event prompting the insertion of the automatic implantable cardioverter defibrillator. It is anticipated this study will provide valuable new insight into the potential use of ranolazine to treat arrhythmias in higher risk patients.
Automatic External Defibrillation Monitoring in Cardiac Arrest
DeathSudden4 moreWe propose to randomize automatic external cardioverter/defibrillators (AECD) in patients who are at high risk for life-threatening abnormal heart rhythms (arrhythmias) and are admitted to the telemetry ward, all other treatments being constant including cardiopulmonary resuscitation. We hypothesize that the automatic, rapid, accurate and specific diagnostic and therapeutic technology used in AECDs will further increase the rate of survival in patients with cardiac arrest through rapid and automatic defibrillation, independent of operator initiation, as compared to standard cardiopulmonary resuscitation initiated by healthcare providers.