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Active clinical trials for "Intervertebral Disc Degeneration"

Results 81-90 of 415

Low Level Lazer Therapy Effect on Vertebral Artery Blood Flow in Elderly With Cervical Disc Degeneration...

Disc Degeneration

This study will include 60 elderly patients with cervical disc degeneration, from both gender who are aged from 60 - 75 years old.

Not yet recruiting5 enrollment criteria

Lumbar Spine Muscle Degeneration Inhibits Rehabilitation-Induced Muscle Recovery

Disc DegenerationLow Back Pain

Low back pain (LBP) is a complex condition that affects 65-85% of the population, and is the leading musculoskeletal condition contributing to disability in the United States. Disc herniation is the most common injury and 75% of individuals undergoing surgical and rehabilitative interventions for this condition experience suboptimal or poor outcomes. These patients demonstrate disability and deficits in functional capacity, including strength and endurance of the lumbar musculature. Muscle-specific changes in individuals with LBP include altered muscle volume, fatty infiltration and fibrosis, and fiber area and type. Importantly, these changes are insensitive to rehabilitation in patients with continued chronic or recurrent symptoms. While normal disuse-related atrophy in the presence of LBP is expected, more severe or chronic pathology, such as inflammation and fiber damage, may be inducing irreversible fiber degeneration and fatty/fibrotic tissue changes that impair muscle function and recovery. While the structural and adaptive capacities of healthy muscle are well understood, muscle recovery in the presence of pathology is less clear. To address this gap in knowledge, the purpose of this project is to compare structural, physiological, and adaptive responses of muscle in the presence of acute and chronic lumbar spine pathology. The central hypothesis is that chronic injury results in a state of muscle inflammation, atrophy, fibrosis, and muscle degeneration that is not responsive to exercise. The Investigators will identify which patients respond to exercise by examining muscle hypertrophic, fibrotic, inflammatory, and adipogenic gene expression profiles. Patients will be followed for six months post-operatively to measure muscle recovery and strength.

Active6 enrollment criteria

Long-Term Assessment of the Safety and Performance of the NuVasive Simplify Disc at Two Levels

Cervical Disc DiseaseDegenerative Disc Disease

A prospective, multicenter post-market clinical follow-up study to evaluate the 10-year long-term safety and effectiveness of the Simplify Disc at two levels in subjects who were enrolled in the IDE study (NCT03123549) and/or post approval study (NCT04980378).

Enrolling by invitation4 enrollment criteria

Cervical Interbody Implant Study

Degenerative Disc DiseaseCervical Spinal Instability

The primary objective of this study is to evaluate the safety and performance of cervical spine surgery using interbody implants as measured by reported complications, radiographic outcomes, and patient-reported outcomes (PROs).

Enrolling by invitation22 enrollment criteria

Natural Matrix Protein™ (NMP™) in Interbody Lumbar Fusion

Degenerative Disc Disease

The objective of this study is to evaluate the performance of Induce Biologics NMP™ when used to promote interbody fusion for degenerative disease of the lumbar spine.

Enrolling by invitation11 enrollment criteria

Outcome Analysis for Minimally Invasive Spine Surgery and Navigation

Degenerative Disc Disease

Prospective/Retrospective data analysis, chart reviews and clinical outcomes of minimally invasive spine surgery

Enrolling by invitation2 enrollment criteria

Advanced Materials Science in XLIF Study

Degenerative Disc DiseaseSpondylolisthesis

This study is being conducted to evaluate the clinical and radiographic outcomes of three different interbody implant types when used with cancellous allograft chips with BMA or cellular allograft in patients undergoing XLIF surgery. The study will evaluate success by comparing the rate of fusion, complications profile, and any relationships between clinical outcomes (pain and function) and radiographic outcomes (fusion rate) between the three implant groups.

Enrolling by invitation35 enrollment criteria

Posterior Cervical Fixation Study

Degenerative Disc DiseaseCraniocervical Injuries7 more

The objective of this study is to evaluate the safety and performance of occipito-cervico-thoracic spine surgery using posterior fixation as measured by reported complications, radiographic outcomes, and patients reported outcomes (PROs).This study is being undertaken to identify possible residual risks and to clarify mid-to long-term clinical performance that may affect the benefit/risk ratio of posterior fixation systems.

Enrolling by invitation21 enrollment criteria

Modulus in XLIF Study

Degenerative Disc DiseaseDegenerative Spondylolisthesis1 more

The primary objective of this study is to evaluate the safety and performance of the Modulus 3D-printed titanium interbody implant in patients undergoing thoracic and/or lumbar XLIF as measured by reported complications, radiographic outcomes, and patient-reported outcomes.

Enrolling by invitation19 enrollment criteria

Long-term Assessment of the Safety and Performance of the NuVasive Simplify Disc

Cervical Disc DiseaseDegenerative Disc Disease

A prospective, multicenter post-market clinical follow-up study to evaluate the 10-year long-term safety and effectiveness of the Simplify Disc in subjects who were enrolled in the post approval study (NCT04630626).

Enrolling by invitation4 enrollment criteria
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