Effects of Strength Exercise on Fall Risk in Elderly With Alzheimer's Disease
Alzheimer DiseaseDementia; Alzheimer's Type (Etiology)3 moreInterventional study to show the effects of strength exercise on fall risk in elderly with Alzheimer's disease
A Study to Evaluate the Safety, Tolerability and Immunogenicity of Tau Targeted Vaccines in Participants...
Alzheimer's DiseaseCognitive Impairment5 moreThis study is a multicenter, double blind, randomized, placebo-controlled study to evaluate the safety, tolerability and immunogenicity of different doses, regimens and combinations of Tau targeted vaccines in participants with early Alzheimer's Disease.
A Study of ATH-1017 in Mild to Moderate Alzheimer's Disease
Alzheimer DiseaseDementia of Alzheimer TypeThis study is designed to evaluate treatment effects of ATH-1017 (fosgonimeton) in mild to moderate Alzheimer's subjects with a randomized treatment duration of 26-weeks.
Anxiety, Stress and Sleep Problems in People With Early Onset Dementia
Early Onset DementiaYoung Onset Dementia7 moreThe aim of this study is to detect and assess needs of people with early onset dementia regarding anxiety, stress and sleep implement a 6 week intervention pilot study in wich weekly (hourly) sessions are implemented in day care settings in order to decrease anxiety, stress and sleep problems in people with early onset dementia
Multiple Dose Safety Study of NPT088 in Patients With Mild to Moderate Probable Alzheimer's Disease...
Alzheimer DiseaseThe purpose of the study is to evaluate the safety and tolerability of multiple doses of NPT088 in patients with mild to moderate probable Alzheimer's Disease. The study will also evaluate the pharmacokinetics, immunogenicity and exploratory pharmacodynamic characteristics of multiple doses of NPT088.
Blood-Brain-Barrier Opening Using Focused Ultrasound With IV Contrast Agents in Patients With Early...
Alzheimer DiseaseThis is a prospective, non-randomized, single-arm, feasibility study to evaluate the safety and initial effectiveness of opening of the Blood-Brain Barrier with intravenous contrast agents using the ExAblate Neuro System in patients with early stage Alzheimer's Disease.
Impact of Physical Activity on Successful Aging
Alzheimer DiseaseCognitive Impairment1 moreEmerging literature suggests that vascular factors might be involved in the pathogenesis of Alzheimer's disease (AD). Other recent studies demonstrate the positive effects of physical activity on cognitive and behavioral disturbances of patients with AD. Therefore, it has been postulated that exercise enchantment in cerebral circulation is the physiological mechanism that link physical exercise and reduction of AD symptoms. Consequently, a program of physical activity could be considered one approach to counteract dementia by improving cerebrovascular health. However at this moment, it is not clear if the progressive brain vascular dysfunction and hypoperfusion, associated with the β-amyloid deposition, might be reversed or stabilized by an exercise intervention. The aim of this study is to assess, in patients with AD, the influence of physical exercise, compared to cognitive stimulation, on: Cognitive function; Independence in daily living and behavioral symptoms; Vascular function Finally, to investigate the physiological processes on the basis of the motor parameters' changes, the performances of the patients will be compared with the performances of healthy young and old subjects. MAIN OBJECTIVE: Investigate, in patients with Mild Cognitive Impairment (MCI) and AD, the effects of a physical activity program, or cognitive stimulation on global cognitive function. SECONDARY OBJECTIVES: Investigate the effects of the two treatments on: cognitive and motor performances, independence in activities of daily living, behavioral symptoms, peripheral vascular function.
Feasibility and Effects of Valaciclovir Treatment in Persons With Early Alzheimer's Disease
Alzheimer DiseaseMild Cognitive Impairment1 moreThis study investigates the effects of Valaciclovir treatment to individuals with Alzheimer's disease or Mild Cognitive Impairment of Alzheimer's Disease Type. It is an open pilot trial where 36 participants will receive 4 weeks of Valaciclovir treatment. Participants will be investigated using different measures before and after the treatment period.
Study of DHP1401 in Patients With Mild-moderate Alzheimer's Disease Treated With Donepezil(DRAMA)...
Mild-moderate Alzheimer's DiseaseThe objective of this study is to evaluate the efficacy and safety of DHP1401 in patients with mild-moderate Alzheimer's disease treated with donepezil
More Than a Movement Disorder: Applying Palliative Care to Parkinson's Disease
Parkinson DiseaseParkinsonism10 moreThis is a two-center (University of Colorado, University of California San Francisco) community-based comparative effectiveness study of outpatient palliative care for Parkinson's disease (PD) and related disorders (progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), multiple systems atrophy (MSA), Lewy Body Dementia (LBD). In September 2018, the study was amended to also include Alzheimer's disease (AD) and related disorders (Frontotemporal Dementia (FTD), Primary Progressive Aphasia (PPA), Vascular Dementia). It will utilize a randomized stepped-wedge design to compare patient and caregiver outcomes between usual care in the community versus usual care augmented by palliative training and telemedicine support to provide other resources (e.g. social work).