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Active clinical trials for "Alzheimer Disease"

Results 2631-2640 of 2939

Alzheimer's Caregiver Communication Study

Alzheimer's Disease

The point of this research is to improve the communicative relationship between the caregiver and care receiver. It is input from the caregiver on these communicative behaviors that will inform the process of understanding how to reduce the caregiver burden that comes from this communicative relationship.

Completed4 enrollment criteria

Brain Aging Project--Kansas University

Alzheimer's Disease

The purpose of this study is to determine the effects of exercise and cardiorespiratory fitness on age-related brain changes.

Completed17 enrollment criteria

Alzheimer's Disease Treatment and Illness Perceptions Survey (TIPS) II

Alzheimer Disease

The TIPS Study, or Treatment and Illness Perceptions Survey, is a study funded by the national Alzheimer's Association to learn more about differences between African Americans' and Whites' attitudes, beliefs, and experiences related to Alzheimer's disease (AD). The study involves a one-time 30-minute telephone survey in which participants are asked about a range of topics related to AD, including their personal experiences, their beliefs about the disease's symptoms and risk factors, and their attitude toward possible future treatment options. Information from the survey will be used to develop more culturally sensitive health education and healthcare services for persons with AD.

Completed6 enrollment criteria

Brain Sleep Deprivation MRI Effects (BEDTIME)

Alzheimer's Disease

The primary purpose of this study is to explore the underlying mechanisms that link sleep to Alzheimer's disease (AD), with special focus on the clearance of metabolites in the extracellular space of the brain during sleep. Subjects will wear an actigraph for 1 week to determine regular daytime activity and sleep patterns. Subjects will then undergo partial sleep deprivation followed by 4 hours of in-lab nocturnal polysomnography (NPSG). Participants will be be asked to stay awake and active all day after the partial sleep deprivation with a new actigraphy secured by a hospital band to assure participants remain awake. They will seep inside an MRI machine for 90 minutes on the following night during their usual bedtime (established by 1 week actigraphy study.) Morphologic imaging, flow imaging and diffusion kurtosis imaging (DKI) will be performed on a 3T Siemens scanner.

Withdrawn12 enrollment criteria

Relationship Between Protein Biomarkers in Cerebrospinal Fluid and Alzheimer&Apos;s Disease in Patients...

Alzheimer's Disease

It is currently accepted that depression during midlife is a risk factor for Alzheimer's disease (AD). Furthermore, several prospective population studies have demonstrated that depression is an independent risk factor for incident dementia of different types (e.g. vascular, mixed, Alzheimer's disease). However, it is not clear, what are the mechanisms that link depression and dementia, and if depression can be a prodromal manifestation of AD. There are also studies that suggest that depression could be an initial sign of AD. Objective: Demonstrate that late life depression (over 60 years of age) constitutes the first manifestation of AD. Define by rating scales and life stressors have differential risk profiles evolutionary AD. To study the relationship between the subtypes of depression and CSF biomarkers, neurophycological test and evolution to AD.

Terminated11 enrollment criteria

Evaluation of Electronic Florbetapir (18F) Interpretation Training in Japanese Physicians

Alzheimer's Disease

This study is designed to validate the Japanese electronic florbetapir (18F) interpretation training program intended for post-approval implementation in Japan.

Withdrawn4 enrollment criteria

Retrieval of Patient Information After Discontinuation

Alzheimer's Disease

A Phase 3b, Study of Subjects With Alzheimer's Disease Who Discontinued Treatment in Bapineuzumab Phase 3 Clinical Studies (ELN115727-301/302/351) or Who Completed Studies ELN115727-301 and 302 but did not Enroll in Study ELN115727-351.

Terminated6 enrollment criteria

TAU PET Imaging in Northern Manhattan Study of Metabolism and Mind

Diabetes MellitusAlzheimer Dementia

The purpose of this project is to study brain imaging of a substance called tau, which is found in brains of persons with Alzheimer's disease, using the Tau binder, 18F-THK-5351, for live imaging of tau in the brain. The main goal of this proposal is to study whether diabetes status (type 2 diabetes [referred to as diabetes] and pre-diabetes, compared with normal glucose tolerance [NGT]), is associated with increased tau accumulation in the brain, one of the culprits of Alzheimer's disease, in a community-based group of middle aged Caribbean-Hispanics with a mean age of 63 years. The investigators propose to conduct tau positron emission tomography (PET) imaging in 30 middle aged Hispanics.

Withdrawn2 enrollment criteria

Tau Tracer Comparison in Healthy Controls and Alzheimer's Disease Patients

HealthyAlzheimer Disease

The primary objective of this study is to identify a new radioligand for imaging of tauopathy in Alzheimer's disease through direct comparisons of two potential candidates, [18F]RO-948 (formerly known as [18F]6958948) and [18F]MK-6240, and demonstration of the candidates' absence of off-target binding.

Withdrawn28 enrollment criteria

Electronic Consultation for AD/ADRD Residents Experiencing Infectious Diseases

Alzheimer's DementiaNursing Homes2 more

Pilot study to evaluate the feasibility of a pilot embedded pragmatic cluster randomized controlled trial to reduce the duration of antibiotic therapy and number of antibiotic prescriptions in nursing home residents with AD/ADRD.

Withdrawn1 enrollment criteria
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