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Active clinical trials for "Depressive Disorder, Major"

Results 731-740 of 2240

Safety and Efficacy of Levomilnacipran ER (F2695 SR) in Major Depressive Disorder

Major Depressive Disorder

The purpose of this study is to evaluate the efficacy, safety, and tolerability of Levomilnacipran ER versus placebo in the treatment of outpatients with major depressive disorder

Completed6 enrollment criteria

Randomised Placebo-controlled Duloxetine-referenced Study of Efficacy and Safety of 15 and 20 mg...

Major Depressive Disorder

The purpose of the study is to evaluate the efficacy, tolerability and the safety of two fixed doses of vortioxetine in the treatment of major depressive disorder.

Completed10 enrollment criteria

Study of the Safety and Efficacy of OPC-34712 as Adjunctive Therapy in the Treatment of Adults With...

Major Depressive Disorder

This is a Double-blind study wherein patients with Major Depressive Disorder (MDD) will receive either from 1 to 3 mg a day of study medication (OPC-34712)or placebo (an inactive substance) in addition to an FDA approved antidepressant in order to determine if the study medication is effective as an add on treatment of MDD.

Completed7 enrollment criteria

This is a Study to Determine the Antidepressant Effects of AZD6765

Treatment Resistant Major Depressive Disorder

The purpose of this study is to determine the antidepressant effects of AZD6765 compared to placebo.

Completed4 enrollment criteria

Long Term Safety and Tolerability of SR58611 in Patients With Major Depressive Disorder

Major Depressive Disorders

Primary objective: - To evaluate the long-term safety and tolerability of SR58611A (amibegron) patients with major depressive disorder (MDD). Secondary objective: - To determine plasma concentrations of SR58878 (the active metabolite of SR58611A), for pharmacokinetic population analyses, to evaluate the quality of life (QoL) in patients with MDD, and to evaluate the efficacy of amibegron in patients with MDD.

Completed1 enrollment criteria

Comparing Quetiapine XR Monotherapy and Augmentation With Lithium Augmentation in TRD Patients

Major Depressive DisorderTreatment Resistant Depression

The primary objective of the study is to evaluate the efficacy of Quetiapine extended release (XR) in combination with an selective serotonin reuptake inhibitor (SSRI) or Venlafaxine versus Lithium in combination with an selective serotonin reuptake inhibitor or Venlafaxine versus Quetiapine extended release monotherapy in subjects with treatment resistant depression as assessed by the changes from randomisation to week 6 in the Montgomery-Åsberg Depression Rating Scale (MADRS) total score. As an independent objective, the primary objective will also be evaluated in two subgroups of patients: (1) patients who were resistant to two previous antidepressant therapies and (2) in the subgroup of patients with one previous failure.

Completed6 enrollment criteria

An Eight-week Study of SSR411298 as Treatment for Major Depressive Disorder in Elderly Patients...

Major Depressive Disorder

The primary objective of this study is to evaluate the efficacy of 3 fixed doses of SSR411298 (10, 50 or 200 mg daily) compared to placebo, in elderly patients with Major Depressive Disorder (MDD), based on the 17-item Hamilton Depression Rating Scale. Secondary objectives are: To evaluate the tolerability and safety of an 8-week treatment with SSR411298 versus placebo in elderly patients with MDD. To evaluate the effect of SSR411298 on disability, anxiety, cognitive function, sleep, pain and somatic symptoms related to depression, and bone markers. To assess SSR411298 plasma concentrations. To assess plasma endocannabinoid concentrations.

Completed8 enrollment criteria

Effect of Quetiapine XR on Sleep in Patients With Major Depression, as Compared With Mirtazapine...

Sleep

The purpose of this study is to examine the effects of (a) quetiapine XR and (b) mirtazapine on sleep when given as an antidepressant (monotherapy). We hypothesize that (a) quetiapine XR has an immediate and lasting positive effect on sleep in depressed patients which does not differ from the impact of mirtazapine on sleep in this group of patients; (b) in the context of a secondary objective, we expect an antidepressant effect of quetiapine XR which is equivalent to that of mirtazapine.

Completed32 enrollment criteria

The Efficacy of Parent Involvement in the Treatment of Adolescent Depression

Major Depressive DisorderDysthymic Disorder2 more

The primary aim of this study is to examine whether adolescent depression and the family context in which it develops is best treated using an individual adolescent intervention or an intervention that includes both the adolescent and the parents. This will be accomplished by conducting a randomized controlled pilot study of Interpersonal Psychotherapy for Depressed Adolescents (IPT-A) in comparison to Interpersonal Psychotherapy for Depressed Adolescents and Parents (IPT-AP).

Completed16 enrollment criteria

Long-Term Administration Study of Aripiprazole as an Adjunctive Therapy in Patients With Major Depressive...

Major Depressive Disorder

To examine the safety and efficacy of long term administration of aripiprazole as an adjunctive therapy, co-administered with either a selective serotonin reuptake inhibitor (SSRI) or a selective-norepinephrine reuptake inhibitor (SNRI), in subjects with major depressive disorder.

Completed13 enrollment criteria
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