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Active clinical trials for "Depressive Disorder, Major"

Results 951-960 of 2240

A Safety, Efficacy and Tolerability Study of SEP-225289

Depressive DisorderMajor

To determine the safety, efficacy and tolerability of SEP-225289 in subjects with Major Depressive Disorder

Completed19 enrollment criteria

Antidepressant Therapy for Bipolar II Major Depression

Bipolar Type II Disorder

This study examines the relative safety and benefit of antidepressant therapy (versus recommended mood stabilizer therapy)of bipolar type II major depressive episode. We hypothesize that antidepressant therapy will be superior to mood stabilizer therapy with little or no difference in treatment emergent manic symptoms.

Completed17 enrollment criteria

A Comparison of Sertraline-reboxetine Combination Therapy Versus Sertraline or Reboxetine Monotherapy...

Depressive DisorderMajor

This study was designed to determine if the novel combination of the SSRI, sertraline, and the NRI reboxetine will increase antidepressant efficacy without sacrificing the favorable safety profile of SSRIs.

Completed6 enrollment criteria

A Comparison of Sertraline Versus Venlafaxine XR in the Treatment of Major Depression

Depressive DisorderMajor

To assess the comparative efficacy of sertraline versus venlafaxine XR on measures of quality of life.

Completed4 enrollment criteria

Acupuncture for Residual Insomnia Associated With Major Depressive Disorder

InsomniaDepression

The purpose of this study is to evaluate the clinical effectiveness of acupuncture treatment on residual insomnia in major depressive patients.

Completed13 enrollment criteria

Efficacy Study of RX-10100 to Treat Major Depressive Disorder (MDD)

Major Depressive Disorder (MDD)

The primary objective of this Phase IIa trial is to determine the effective dose and treatment period for an upcoming RX-10100 Phase IIb trial in subjects with major depression disorder (MDD). The secondary objectives of this trial are to evaluate the safety and quality of life in subjects with MDD receiving RX-10100 treatment.

Completed44 enrollment criteria

Contingency Management of Psychostimulant Abuse in the Severely Mentally Ill

Drug AbuseSchizophrenia2 more

The purpose of this study is to determine the effectiveness of a behavioral treatment, contingency management, in reducing stimulant use in persons with serious mental illness.

Completed11 enrollment criteria

A Study of CX157 (TriRima) for the Treatment of Depression

Major Depressive Disorder

The purpose of this study is to examine the efficacy of CX157 60 mg administered three times a day (180 mg daily dose) as compared to placebo in subjects with Major Depressive Disorder (MDD). Secondary objectives are to evaluate the safety and tolerability and steady state pharmacokinetic profile of CX157 in these subjects.

Completed37 enrollment criteria

Stress Generation and Recurrent Depression: The Role of Differential Treatment Response

DepressionMajor Depressive Disorder

Depression affects over one million people in Canada, resulting in $14.4 billion per year in costs to Canadian society. In order to prevent this often lifelong disorder, it is critically important to identify risk factors for the recurrence of depression. A crucial force in maintaining depression is the generation of stressful life events. That is, individuals who have a history of depression are likely to generate the very events that precipitate future depressive episodes (e.g., relationship break-up, fired from job, conflicts with the law) due to negative personality characteristics and disrupted social support networks resulting from previous episodes. This project is the first to test a model that examines the role of negative personality, low social support, and childhood abuse and neglect as risk factors for the generation of stressful life events that predict future depression. We will test this model in a group of patients meeting formal criteria for depression who will be treated and then followed up for 12 months or until depression recurrence. With this long-term design we will be in a unique position to understand how depression is maintained over time, thus suggesting important treatment strategies to prevent depression recurrence.

Completed15 enrollment criteria

A Double-Blind, Placebo-Controlled Study of Aripiprazole Adjunctive to Antidepressant Therapy

Major Depressive Disorder

The purpose of this study is to determine whether a reduced dose of aripiprazole is effective in treating patients with major depressive disorder

Completed53 enrollment criteria
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