Mom: Managing Our Mood, Part of The Family Help Program
Postpartum DepressionThe purpose of the MOM: Managing Our Mood Program (part of Family Help) is to evaluate the effectiveness of the Family Help distance intervention compared to usual or standard care typically provided to women with mild to moderate postpartum depression symptomology. This is a single-center trial based at the IWK Health Center. The primary outcome is change in postpartum depression diagnosis.
Effectiveness of Sertraline Alone and Interpersonal Psychotherapy Alone in Treating Women With Postpartum...
DepressionPostpartumThis study will evaluate the effectiveness of antidepressant medication alone and interpersonal psychotherapy alone in treating women with postpartum depression.
Identification and Therapy of Postpartum Depression
DepressionThis study will evaluate the effectiveness of a telephone-based depression screening and care management program in treating depression in postpartum women.
Functional Outcome in Postpartum Depression in Women Treated With Desvenlafaxine
DepressionPostpartum depressed women suffer from functional impairment in their mood, thoughts, cognition and physical well being leading to poor motivation, bonding difficulties, decreased productivity, conflict and neglect. Moderate/ severe depression responds best to a combination of antidepressants and counseling. This study will estimate the proportion of women who return to functionality after treatment with Desvenlafaxine and examine the differential impact of change in depression and anxiety symptoms on functionality over twelve weeks. Depression and anxiety symptoms will be monitored through six mood questionnaires; functional recovery will be monitored through a simple self-report questionnaire at each visit.
Escitalopram (Lexapro) for the Treatment of Postpartum Depression
Postpartum DepressionThe purpose of this study is to determine whether women with postpartum major depressive disorder (MDD) will experience a significant decrease in depressive symptoms from baseline over an eight-week treatment intervention with escitalopram (Lexapro). Also, to determine whether women with postpartum MDD will experience a significant decrease in anxiety symptoms.
A Study to Evaluate Safety and Efficacy of SAGE-547 in Participants With Moderate Postpartum Depression...
Postpartum DepressionThe purpose of this study was to determine if SAGE-547 Injection infused intravenously at up to 90 μg/kg/h for 60 hours reduces depressive symptoms in participants with moderate postpartum depression (PPD) compared to placebo injection as assessed by the change from baseline in Hamilton Rating Scale for Depression (HAM-D) total score.
Virtual Reality Biofeedback for Postpartum Anxiety and Depression
Anxiety and DepressionPostpartum Depression1 moreThe purpose of this pilot trial is to test patient feasibility and acceptability of virtual reality biofeedback program in postpartum women for anxiety and depression outcomes.
Sequence Variations of Genes in the Estrogen Pathway and Perinatal Depression
Postnatal DepressionGenetic PredispositionTo elucidate the disease pathway of perinatal depression by identifying genetic variants which could play a role in predisposing to the condition and/or lead to better understanding of the pathogenesis of the condition. This is achieved by investigating for associations between oestrogen receptor genetic variants and perinatal depression.
Three Model Care Pathways for Postnatal Depression
Postnatal DepressionThe study evaluates three best-practice care pathways for postnatal depression (PND) by comparing sole General Practitioner (GP) management to GP management in combination with CBT-based counselling from either a Psychologist or a Maternal and Child Health Nurse (MCHN).
Neuraxial Preservative Free Morphine for Normal Spontaneous Vaginal Delivery
Postpartum PainPostpartum Depression1 morePatients presenting for normal spontaneous vaginal delivery who have a neuraxial anesthestic will be randomized to receive preservative free morphine or saline placebo after delivery.