Active clinical trials for "Depression"

Research and follow-up of the course and outcome of high-risk pregnant women with perinatal depression in the third trimester; Factors affecting the outcome of the disease; Recurrence of PND in pregnancy again; The influence of different intervention methods on the course of the disease.

In the project, investigators basically plan to test the difference in social behavior and social cognition between depressive patients and healthy individuals. To test this, investigators plan to use traditional or novel behavioral experiment paradigms to target various behaviors.

To investigate the structural/functional abnormalities and the possible genetic endophenotypes of in the Type 2 Diabetes Patient With Depression.

The purpose of this study is to examine clinical characteristics of Korean adolescents with depression who have suicidal ideation and behavior. We formulate those hypotheses. Being bullied in peer relationships, excessive use of internet, excessive extra-curricular tutoring, sexual abuse in childhood, physical abuse and emotional neglect are risk factors of suicide in adolescents. Depression of parents and negative child-rearing attitude are risk factors of suicidal ideation and behavior in adolescents. Emotional quotient (EQ) and resilience of adolescent are protective factors of suicide.

To investigate the prevalence of psychological symptoms and sexual dysfunction, and to estimate their possible interactions in infertile men.

The goal of this research study is to understand the relationship between the hormone oxytocin and postpartum mood. Based on previous research, the investigators hypothesize that lower plasma oxytocin concentration during pregnancy will predict a greater likelihood of postpartum depression. Second, it is expected that oxytocin concentration in the third trimester will show an inverse relationship with the severity of depressive symptoms at 4 - 6 weeks postpartum. Potential participants in the study will be screened for eligibility during their third trimester of pregnancy, using a combination of questionnaires. Those who are eligible for participation will have one blood sample drawn at this time, and then be asked to complete a follow up questionnaire at 4-6 weeks postpartum to assess for depressive mood symptoms. This follow up questionnaire can be completed either in person or on the telephone. Anyone who is interested in receiving help for their mood at any point in the study will receive referrals.

This study aims to examine the relationship between mood and brain activity in adolescent girls in order to better understand the genetic and neural predictors of adolescent depression. The participants in this study will be healthy female adolescents aged 12-14 and their mothers. They will participate for a total of six months. Adolescent participants will have three study sessions at McLean Hospital, and during two of them, their mothers will also have assessments. Adolescent assessments will include interviews, questionnaires, computer tasks, and collection of a saliva sample for genetic analyses. Their second study visit will include an fMRI scan. Parent assessments will include an interview, questionnaires, and a computer task.

An objective measure of treatment response could be a valuable new tool in the armamentarium of depression management, and this holds true for stimulation-based and pharmacological therapies alike. Hence, the Medibio Depression Monitoring Study will use the Medibio analytics platform to characterize autonomic, circadian, and sleep patterns before and during the initial 8 weeks of pharmacologic therapy for moderate-to-severe depression. The study will also explore any differences in these measures between treatment responders and non-responders, and between depression subtypes, including bipolar and unipolar depression. The study will also characterize longitudinal, ambulatory EEG measures throughout the observation period.

this reseach examines the reliability and validity of 17 items- Hamilton Depression rating scale in Vietnamese population, which has been commonly used in clinical depression practice and study.

Early improvemrnt, decreased 20% in the 17 items of Hamilton Depression Rating Scale (HAMD-17) at the second week of the treatment of major depression disorder (MDD), can arguably predict the remission at the 12th week. Our observation study including 80 MDD patients will access resting-state function MRI to finding factors which infuencing early improvemrnt, respone and remission of antidepressants.