Autoregulation of Glomerular Filtration Rate in Patients With Type 1 Diabetes During Spironolactone...
HypertensionTo evaluate the impact of spironolactone treatment on renal autoregulation in hypertensive type 1 diabetic patients.
Insulin Glulisine, Diabetes Mellitus Type 1
Diabetes MellitusType 1To provide local data on efficacy and safety of insulin glulisine in patients with Type 1 Diabetes Mellitus receiving insulin glargine as basic insulin therapy
Treatment for Symptomatic Peripheral Neuropathy in Patients With Diabetes
Diabetic NeuropathiesDiabetes Mellitus3 moreThe purpose of this protocol is to determine if an investigational drug is effective in treating nerve malfunction in diabetes.
Safety and Efficacy of NovoLog vs. Humalog in Insulin Pumps in Children and Adolescents
DiabetesDiabetes Mellitus1 moreThis trial is conducted in the United States of America (USA). It is demonstrated that intensive insulin therapy resulting in good glycaemic control can reduce or delay the incidence of complications secondary to Type 1 Diabetes. Insulin Aspart (NovoLog®) is an ideal insulin to use in an intensive insulin regimen using continuous subcutaneous insulin injection (CSII) therapy in the pediatric and adolescent age population. This trial compares the safety and efficacy of Insulin Aspart (NovoLog®) and Insulin Lispro (Humalog®) delivered by CSII in children and adolescents with type 1 diabetes.
Comparison of the Ability of Glulisine With Lispro to Control Type 1 Diabetes Mellitus in Children...
Diabetes MellitusInsulin-DependentThe purpose of this study is to determine if insulin glulisine (Apidra) is as safe and effective a rapid acting insulin as insulin lispro (Humalog) in children and adolescents with type 1 diabetes mellitus.
Study of Human Insulin Inhalation Powder in Patients With Type 1 Diabetes
Diabetes MellitusType 1This is a phase 3, open-label, randomized study to evaluate the safety and efficacy of the Lilly/Alkermes inhaled insulin system compared to injected pre-meal insulin in non-smoking patients with type 1 diabetes. Patients will be treated for 24 months with a 2-month follow-up period.
Continuous Glucose Monitors for Children With Diabetes Mellitus
Diabetes MellitusInsulin-DependentGood control of blood glucose levels is important in preventing complications from diabetes. This study assessed the accuracy and reliability of two FDA-approved continuous glucose monitors, the Continuous Glucose Monitoring System (CGMS) and the GlucoWatch G2 Biographer (GW2B), in children with type 1 diabetes mellitus (T1DM).
Interferon-Alpha for Diabetes Mellitus Type 1
Insulin-Dependent Diabetes MellitusThis study will see if interferon-alpha given early in the disease can stop or slow the immune attack on insulin-producing cells. In addition, the study will examine the safety and efficacy of interferon-alpha (given by mouth) to protect beta cell function. Patients between 3 and 25 years of age with Type 1 Diabetes Mellitus less then six weeks may be eligible for this study. All study-related tests and medications at the NIH Clinical Center are provided at no cost.
Apelin as a Marker of Early Complications in Type 1 Diabetes Mellitus
Diabetes MellitusType 1Aims of the Research : assessment of serum apelin levels in patients with T1DM with comparison to non-diabetic controls. investigate the relation between serum apelin levels and glycemic balance. clarify the the relation between serum apelin and lipid concentrations.
CloudCare in the Treatment of Type 1 Diabetes in Pediatrics
Type1diabetesPediatric ALLThis prospective cohort study aims to estimate the effect of the CloudCare application in daily practice on treatment satisfaction and emotional burden for pediatric patients and their parents/caregivers, patients' glycemic control (glucometrics), healthcare professional satisfaction, and the impact on costs. A total of 600 pediatric patients (1-15 years) with type 1 diabetes will be enrolled into the study.