A Study on the Effect of 2 Pen Devices on HbA1c
Diabetes MellitusType 1The purpose of this study is to test the hypothesis that the HumaPen Memoir with memory function, when used over 24 weeks for prandial insulin injections achieves superior glycemic control, when compared to the conventional HumaPen Luxura without memory function.
Comparison of Glycemic Control Achieved With 2 Different Needles
DiabetesDiabetes Mellitus4 moreThis trial is conducted in the United States of America (USA). The aim of this trial is to investigate if a 31 gauge x 6 mm needle will provide comparable blood glucose control to the 29 gauge x 12.7 mm needle in obese subjects with diabetes.
Comparison of Human Insulin to Insulin Inhalation Solution in Children With Type 1 Diabetes
DiabetesDiabetes Mellitus1 moreThis trial is conducted in Europe. The aim of this trial is to compare the pharmacokinetic profile of two different methods of insulin administration in children with type 1 diabetes.
Effect of Continuous Glucose Monitoring on Course of Glucose in Type 1 Diabetes
Type 1 DiabetesHypoglycemiaThe objective of this cross over study is to access if continuous glucose monitoring (CGMS) with a real time feed back and hypoglycemic as well as hyperglycemic glucose alerts vs. only retrospective analysis of glucose values is able to improve course of glucose with special regard to time spent in hypoglycemic glucose ranges in type 1 diabetic patients with impaired hypoglycemia awareness or a history of severe hypoglycemia. The second objective is to access satisfaction with CGMS during both conditions
Pharmacokinetics of IAsp Following CSII in Patients With T1DM
Type 1 Diabetes MellitusThe primary objective of the study is to compare SSPIAsp during CSII giving one bolus per hour compared with multiple boluses per hour. The secondary objective is to compare SSPIAsp during continuous subcutaneous insulin infusion (CSII) versus continuous intravenous insulin infusion (CIII).
African-American Diabetes Intervention Project
Insulin-Dependent Diabetes MellitusA controlled trial to assess the potential benefit of a home based worker in improving control in African-American children with insulin dependent diabetes.
A Trial to Compare BioChaperone Insulin Lispro Formulations With US Approved Humalog® and With EU...
Type 1 DiabetesThis is a single-centre, randomised, double-blind, 4-way crossover, 4-treatment, euglycaemic clamp study in subjects with Type 1 Diabetes Mellitus (T1DM). Each subject will be randomly allocated to one of four treatment sequences. Each sequence comprises one single dose of each of four IMPs. IMP1 and IMP2 are BioChaperone lispro formulations. They have the same composition and correspond to different development stages of a unique product which is BioChaperone insulin lispro; between them, improvements were made to prepare industrial production. Comparators (IMP3 and IMP4) are US-approved Humalog® and EU-approved Humalog®. All IMPs will be dosed at 0.2 U/Kg of insulin lispro on 4 dosing visits separated by a washout period of 5 to 15 days. The trial will compare the characteristics of BioChaperone insulin lispro fully liquid (IMP2) formulation to US-approved Humalog and EU-approved Humalog.
Cardiopulmonary Testing for Potential Pancreas Transplant Candidates
Cardiovascular Risk FactorDiabetes Mellitus2 morePatients being assessed for Kidney Pancreas transplantation often have pre-existing co-morbid disease that contributes to structural cardiac and vascular disease. There is no consensus on optimal pre-listing cardiac assessment to reliably minimize risk of peri-operative cardiac events. Functional status using the cardio-pulmonary exercise test (CPET) has been used in cardiac and abdominal surgery, including abdominal aortic aneurysm (AAA) repair and kidney transplantation, but high risk patients with diabetes are often lacking from these studies. This study will investigate the correlation between function, measures using CPET and standard cardiac assessment, and determine the variation in usual measures of anaerobic threshold and VO2 max in this population.
A Comparison of Postprandial Glucose After a MMTT, and the Metabolic Effects of Insulin Withdrawal...
DiabetesDiabetes Mellitus3 moreThis is an inpatient treatment, double-blind, randomized, 3-way crossover study in T1DM subjects using insulin pump therapy.
Meal Handling of Advanced Closed Loop Insulin Delivery.
Type 1 DiabetesThe study will Compare meal related glycemic indices following 2 types of meal announcement: Conventional assessment of carb content plus carb equivalence of proteins and fat Algorithm device optimal universal meal announce equivalent